Mean platelet volume could not predict infarct size in patients with acute ST elevation myocardial infarct

Yıl 2012, Cilt: 1 Sayı: 3, 120 - 124, 01.09.2012

Serkan Öztürk İsmail Doğan Kayıhan Karaman Alim Erdem Mehmet Fatih Özlü Suzi Selim Ayhan Mehmet Yazıcı

https://doi.org/10.5505/abantmedj.2012.49369

Öz

Background: Increased mean platelet volume has been shown to associate with acute coronary syndromes. Aim of this study, to investigate the relationship between scintigraphic infarct size and mean platelet volume after acute ST elevation myocardial infarction STEMI , which has not been studied with imaging tools. Method: Fifth-four patients with acute STEMI 31 patients with anterior and 23 patients with inferior were included in the study who were performed single photon emission computed tomography SPECT . In all cases, venous peripheral blood samples for hematologic and biochemical measurements were drawn. Platelet count, mean platelet volume, creatine kinase-myocardial band protein CKMB protein , and cardiac troponin cTnT were obtained at admission and daily during the first 72 h after a patient’s arrival by laboratory record. The severity scores of infarct size were calculated by SPECT. Results: Peak CKMB-protein, peak cTnT were positively correlated with, scintigraphic infarct size but mean platelet volume was not correlated with scintigraphic infarct size P=0,021, P

Anahtar Kelimeler

Mean Platelet Volume, Infarct Size, Acute Coronary Syndrome.

Ortalama trombosit hacmi; akut ST elevasyonlu miyokard enfarktüsünde infarkt büyüklüğünün öngördürücüsü değildir

Öz

Amaç: Artmış ortalama trombosit hacmi ile akut koroner sendrom arasındaki ilişki bilinmektedir. Bu çalışmada ST elevasyonlu miyokard infarktüsü STEMI ile başvuran hastalarda sintigrafik olarak tespit edilen infarkt büyüklüğü ile ortalama trombosit hacmi arasındaki ilişkinin belirlenmesi amaçlanmıştır. Yöntem: : Akut ST elevasyonlu MI ile hastaneye kabul edilen ve hastane kayıtlarından SPECT analizi olan 54 hasta 31 adet Anterior MI, 23 adet İnferior MI çalışmaya dahil edildi. Hastaların başvuru anında ve 24, 48, 72 saat sonrasında periferik venöz kandan alınan serum örnekleri ile hemogram, serum kardiyak kreatin kinaz miyokardiyal band CK-MB ve troponin T cTnT düzeyleri laboratuar kayıtlarından elde edildi. Trombosit sayısı, ortalama trombosit hacmi ve kardiyak enzim düzeyleri kaydedildi. Miyokardiyal nekroz alanının büyüklüğü SPECT analizi ile hesaplandı. Bulgular: Pik CK-MB ve cTnT düzeyleri örnek alınan her üç gün için aynı sonuç geçerli olmak üzere sintigrafik infarkt alanı ile pozitif ilişkili iken, ortalama trombosit hacmi ile ilişkili bulunmadı P=0,021, P

Anahtar Kelimeler

Ortalama Trombosit Hacmi, İnfarkt Alanı, Akut Koroner Sendrom.

Kaynakça

• 1. Van der Loo B, Martin JF. A role for changes in platelet production in the cause of acute coronary syndromes. Arterioscler Thromb Vasc Biol 1999;19:672- 9.
• 2. Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and longterm mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol 2005;46:284-90.
• 3. Martin JF, Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet 1991; 338:1409-11.
• 4. Pabón Osuna P, Nieto Ballesteros F, Moríñigo Muñoz JL, Sánchez Fernández PL, Arribas Jiménez A, Diego Domínguez M, et al. The effect of the mean platelet volume on the short-term prognosis of acute myocardial infarct. Rev Esp Cardiol 1998;51:816-22. [Abstract]
• 5. Slomka PJ, Fieno D, Thomson L, Friedman JD, Hayes SW, Germano G, Berman DS. Automatic detection and size quantification of infarcts by myocardial perfusion SPECT: clinical validation by delayedenhancement MRI. J Nucl Med 2005; 46:728–735.
• 6. Chouraqui P, Livschitz S, Baron J, Moalem I, Shechter M. The assessment of infarct size in postmyocardial infarction patients undergoing thallium-201 tomographic imaging is improved using attenuation correction. Clin Nucl Med 2004; 29: 352-7.
• 7. De Sutter J, Van de Wiele C, D'Asseler Y, De Bondt P, De Backer G, Rigo P, Dierckx R. Automatic quantification of defect size using normal templates: a comparative clinical study of three commercially available algorithms. Eur J Nucl Med 2000; 27: 1827-34.
• 8. Maddahi J, Van Train K, Prigent F, Garcia EV, Friedman J, Ostrzega E, Berman D. Quantitative single photon emission computed thallium-201 tomography for detection and localization of oronary artery disease: optimization and prospective validation of a new technique. J Am Coll Cardiol 1989; 14: 1689– 1699.
• 9. Cloninger KG, DePuey EG, Garcia EV, Roubin GS, Robbins WL, Nody A, DePasquale EE, Berger HJ. Incomplete redistribution in delayed thallium-201 single photon emission computed tomographic (SPECT) images: an overestimation of myocardial scarring. J Am Coll Cardiol 1988; 12:955–963.
• 10. Gibbons RJ, Valeti US, Araoz PA, Jaffe AS. The quantification of infarct size. J Am Coll Cardiol 2004; 44:1533–1542.
• 11. Tzivoni D, Koukoui D, Guetta V, Novack L, Cowing G. Comparison ofTroponin T to creatine kinase and to radionuclide cardiac imaging infarct sizein patients with ST-elevation myocardial infarction undergoing primary angioplasty. Am J Cardiol 2008; 101:753– 757.
• 12. Villanueva FS, Glasheen WP, Sklenar J, Kaul S. Characterization of spatial patterns of flow within the reperfused myocardium by myocardial contrast echocardiography. Implications in determining extent of myocardial salvage. Circulation. 1993;88:2596–2606.
• 13. Kaul S. Myocardial contrast echocardiography: 15 years of research and development. Circulation. 1997;96:3745–3760.
• 14. Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, Finn JP, Judd RM. An improved MR imaging technique for the visualization of myocardial infarction. Radiology.2001;218:215–223.
• 15. Mahrholdt H, Wagner A, Judd RM, Sechtem U. Assessment of myocardial viability by cardiovascular magnetic resonance imaging. Eur Heart J. 2002;23:602–619.
• 16. Kishk YT, Trowbridge EA, Martin JF. Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site. Clin Sci 1985: 68:419–425
• 17. Pereg D, Berlin T, Mosseri M. Mean platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction. Platelets. 2010;21:117-21.
• 18. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8:148-56.
• 19. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148–56