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The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats

Yıl 2022, Cilt 11, Sayı 2, 231 - 242, 31.08.2022
https://doi.org/10.47493/abantmedj.1120849

Öz

Objective: Opioid dependence is a chronic complicated disorder characterized by relapse and remission. Chronic administration of morphine causes symptoms of physical and psychological dependence. The purpose of the present study was to investigate the effect of anti-addictive drugs such as bupropion and varenicline on morphine dependence and naloxone precipitated withdrawal syndrome in a rat model.
Materials and Methods: To assess the physical dependence of morphine, adult male Wistar rats were administered intraperitoneally (i.p.) increasing doses of morphine twice daily for 5 days, 4 hours after a single dose of morphine on day 6, and 15 minutes before subcutaneous (s.c.) naloxone (2 mg/kg, s.c.) administration to elicit withdrawal symptoms. Physical dependence was evaluated by injecting bupropion (5, 10, and 20 mg/kg, i.p.) and varenicline (0.5. 1, and 2 mg/kg, s.c.) for 15 minutes.
Results: The morphine-dependent rats more significantly demonstrated withdrawal symptoms than naive control rats. The results elucidated that administration of bupropion and varenicline during induction of morphine dependence attenuated the most of the severity of withdrawal symptoms. Co-administration of bupropion with morphine reduced withdrawal symptoms such as jumping, wet dog shaking, weight loss and total withdrawal symptoms. Co-administration of varenicline with morphine was found to be effective on withdrawal symptoms such as bupropion, but had no effect on weight loss.
Conclusion: These outcomes provide preliminary data which show that bupropion and varenicline can be used as a candidate drugs to attenuate morphine withdrawal symptoms.

Kaynakça

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Sıçanlarda Bupropion ve Vareniklinin Morfin Yoksunluğu Sendromu Üzerine Etkileri

Yıl 2022, Cilt 11, Sayı 2, 231 - 242, 31.08.2022
https://doi.org/10.47493/abantmedj.1120849

Öz

Amaç: Opioid bağımlılığı, nüks ve remisyon ile karakterize kronik ve karmaşık bir hastalıktır. Kronik morfin uygulaması, fiziksel ve psikolojik bağımlılık semptomlarına neden olur. Bu çalışmanın amacı, bupropion ve vareniklin gibi anti-bağımlılık ilaçlarının morfin bağımlılığı ve nalokson ile hızlanırılmış yoksunluk sendromu üzerindeki etkisini sıçan modelinde araştırmaktı.
Gereç ve Yöntemler: Morfine bağlı fiziksel bağımlılığı değerlendirmek için, yetişkin erkek Wistar sıçanlarına 5 gün boyunca günde iki kez artan dozlarda morfin intraperitoneal (i.p.) uygulandı. 6. günde tek doz morfin uygulamasından 4 saat sonra yoksunluk semptomlarını ortaya çıkarmak için subkutan (s.c.) nalokson (2 mg/kg, s.c.) uygulaması yapıldı. Fiziksel bağımlılık, 15 dakika süreyle intraperitoneal (i.p.) bupropion (5, 10 ve 20 mg/kg, i.p.) ve vareniklin (0,5, 1 ve 2 mg/kg, s.c) verilerek değerlendirildi.
Bulgular: Morfin gurubunda kontrol grubuna göre önemli ölçüde yoksunluk semptomları görüldü. Sonuçlar, morfin bağımlılığının indüklenmesi sırasında bupropion ve vareniklin uygulamasının, yoksunluk semptomlarının şiddetinin çoğunu azalttığını gösterdi. Bupropionun birlikte uygulanması, sıçrama, ıslak köpek silkelenmesi, kilo kaybı ve toplam yoksunluk semptomlarını azaltmıştır. Vareniklinin birlikte uygulanmasının bupropion gibi yoksunluk semptomları üzerinde etkili olduğu, ancak kilo kaybı üzerinde etkisi olmadığı saptandı.
Sonuç: Bu sonuçlar, bupropion ve vareniklinin morfininin yoksunluk semptomlarını hafifletmek için aday ilaçlar olarak kullanılabileceğine dair ön veriler sağlamaktadır.

Kaynakça

  • 1. PERGOLIZZI J. V., JR., RAFFA R. B., ROSENBLATT M. H. Opioid withdrawal symptoms, a consequence of chronic opioid use and opioid use disorder: Current understanding and approaches to management, Journal of clinical pharmacy and therapeutics 2020: 45: 892-903.
  • 2. CANAMO L. J., TRONCO N. B. Clinical Opioid Withdrawal Scale (COWS): Implementation and Outcomes, Critical care nursing quarterly 2019: 42: 222-226.
  • 3. YUNUSOĞLU O. Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool, Alcohol (Fayetteville, NY) 2022: 98: 55-63.
  • 4. WANG S. Historical Review: Opiate Addiction and Opioid Receptors, Cell transplantation 2019: 28: 233-238.
  • 5. SRIVASTAVA A. B., MARIANI J. J., LEVIN F. R. New directions in the treatment of opioid withdrawal, Lancet (London, England) 2020: 395: 1938-1948.
  • 6. BELL J., STRANG J. Medication Treatment of Opioid Use Disorder, Biological psychiatry 2020: 87: 82-88.
  • 7. ALLAHVERDIYEV O., TÜRKMEN A. Z., NURTEN A., SEHIRLI I., ENGINAR N. Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences, Turkish journal of medical sciences 2015: 45: 1380-1389.
  • 8. LISTOS J., ŁUPINA M., TALAREK S., MAZUR A., ORZELSKA-GÓRKA J., KOTLIŃSKA J. The Mechanisms Involved in Morphine Addiction: An Overview, International journal of molecular sciences 2019: 20.
  • 9. MAMALIGAS A. A., CAI Y., FORD C. P. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission, Scientific reports 2016: 6: 37834.
  • 10. ISE Y., NARITA M., NAGASE H., SUZUKI T. Modulation of kappa-opioidergic systems on mecamylamine-precipitated nicotine-withdrawal aversion in rats, Neuroscience letters 2002: 323: 164-166.
  • 11. YAMAMOTO A., KIGUCHI N., KOBAYASHI Y., MAEDA T., UENO K., YAMAMOTO C. et al. Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation, Life sciences 2011: 89: 956-961.
  • 12. REZAYOF A., ZATALI H., HAERI-ROHANI A., ZARRINDAST M. R. Dorsal hippocampal muscarinic and nicotinic receptors are involved in mediating morphine reward, Behavioural brain research 2006: 166: 281-290.
  • 13. DAVENPORT K. E., HOUDI A. A., VAN LOON G. R. Nicotine protects against mu-opioid receptor antagonism by beta-funaltrexamine: evidence for nicotine-induced release of endogenous opioids in brain, Neuroscience letters 1990: 113: 40-46.
  • 14. ISOLA R., ZHANG H., TEJWANI G. A., NEFF N. H., HADJICONSTANTINOU M. Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum, Psychopharmacology 2009: 201: 507-516.
  • 15. ZARRINDAST M. R., FARZIN D. Nicotine attenuates naloxone-induced jumping behaviour in morphine-dependent mice, European journal of pharmacology 1996: 298: 1-6.
  • 16. SUH H. W., SONG D. K., CHOI S. R., CHUNG K. M., KIM Y. H. Nicotine enhances morphine- and beta-endorphin-induced antinociception at the supraspinal level in the mouse, Neuropeptides 1996: 30: 479-484.
  • 17. MCCLUNG C. A., NESTLER E. J., ZACHARIOU V. Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area, The Journal of neuroscience : the official journal of the Society for Neuroscience 2005: 25: 6005-6015.
  • 18. SCAVONE J. L., VAN BOCKSTAELE E. J. Mu-opioid receptor redistribution in the locus coeruleus upon precipitation of withdrawal in opiate-dependent rats, Anatomical record (Hoboken, NJ : 2007) 2009: 292: 401-411.
  • 19. FRYER J. D., LUKAS R. J. Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine, The Journal of pharmacology and experimental therapeutics 1999: 288: 88-92.
  • 20. BUDZYŃSKA B., BIAŁA G. Effects of bupropion on the reinstatement of nicotine-induced conditioned place preference by drug priming in rats, Pharmacological reports : PR 2011: 63: 362-371.
  • 21. TRIVEDI M. H., WALKER R., LING W., DELA CRUZ A., SHARMA G., CARMODY T. et al. Bupropion and Naltrexone in Methamphetamine Use Disorder, The New England journal of medicine 2021: 384: 140-153.
  • 22. GLOVER E. D., GLOVER P. N. Pharmacologic treatments for the nicotine dependent smoker, American journal of health behavior 2001: 25: 179-182.
  • 23. DONG J., BLIER P. Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment, Psychopharmacology 2001: 155: 52-57.
  • 24. CRYAN J. F., O'LEARY O. F., JIN S. H., FRIEDLAND J. C., OUYANG M., HIRSCH B. R. et al. Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors, Proceedings of the National Academy of Sciences of the United States of America 2004: 101: 8186-8191.
  • 25. COOPER B. R., WANG C. M., COX R. F., NORTON R., SHEA V., FERRIS R. M. Evidence that the acute behavioral and electrophysiological effects of bupropion (Wellbutrin) are mediated by a noradrenergic mechanism, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994: 11: 133-141.
  • 26. GOLDEN R. N., DE VANE C. L., LAIZURE S. C., RUDORFER M. V., SHERER M. A., POTTER W. Z. Bupropion in depression. II. The role of metabolites in clinical outcome, Archives of general psychiatry 1988: 45: 145-149.
  • 27. NEWTON T. F., ROACHE J. D., DE LA GARZA R., 2ND, FONG T., WALLACE C. L., LI S. H. et al. Bupropion reduces methamphetamine-induced subjective effects and cue-induced craving, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006: 31: 1537-1544.
  • 28. ELKASHEF A. M., RAWSON R. A., ANDERSON A. L., LI S. H., HOLMES T., SMITH E. V. et al. Bupropion for the treatment of methamphetamine dependence, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008: 33: 1162-1170.
  • 29. CARROLL F. I., BLOUGH B. E., ABRAHAM P., MILLS A. C., HOLLEMAN J. A., WOLCKENHAUER S. A. et al. Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction, Journal of medicinal chemistry 2009: 52: 6768-6781.
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Ayrıntılar

Birincil Dil İngilizce
Konular Tıp
Bölüm Araştırma Makaleleri
Yazarlar

Oruç YUNUSOĞLU> (Sorumlu Yazar)
BOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ
0000-0003-1075-9574
Türkiye


Çagla KÖSE>
ISTANBUL UNIVERSITY, CERRAHPAŞA SCHOOL OF MEDICINE, MEDICINE PR.
0000-0002-3298-6746
Türkiye


Andleeb SHAHZADİ>
ISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPAŞA SCHOOL OF MEDICINE, CERRAHPAŞA MEDICINE PR.
0000-0002-2774-2325
Türkiye


Sibel ÖZYAZGAN>
İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.
0000-0002-2511-3541
Türkiye


Bülent DEMİR>
İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.
0000-0003-1767-408X
Türkiye


Burak ÖNAL>
BİRUNİ ÜNİVERSİTESİ
0000-0002-7846-875X
Türkiye


Ahmet Gökhan AKKAN>
İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.
0000-0002-6799-1721
Türkiye

Yayımlanma Tarihi 31 Ağustos 2022
Gönderilme Tarihi 30 Mayıs 2022
Kabul Tarihi 22 Haziran 2022
Yayınlandığı Sayı Yıl 2022, Cilt 11, Sayı 2

Kaynak Göster

Bibtex @araştırma makalesi { abantmedj1120849, journal = {Abant Tıp Dergisi}, issn = {1305-4392}, eissn = {2147-1800}, address = {Abant Tıp Dergisi Editörlüğü Bolu Abant İzzet Baysal Üniversitesi Tıp Fakültesi, 14280 / BOLU}, publisher = {Bolu Abant İzzet Baysal Üniversitesi}, year = {2022}, volume = {11}, number = {2}, pages = {231 - 242}, doi = {10.47493/abantmedj.1120849}, title = {The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats}, key = {cite}, author = {Yunusoğlu, Oruç and Köse, Çagla and Shahzadi, Andleeb and Özyazgan, Sibel and Demir, Bülent and Önal, Burak and Akkan, Ahmet Gökhan} }
APA Yunusoğlu, O. , Köse, Ç. , Shahzadi, A. , Özyazgan, S. , Demir, B. , Önal, B. & Akkan, A. G. (2022). The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats . Abant Tıp Dergisi , 11 (2) , 231-242 . DOI: 10.47493/abantmedj.1120849
MLA Yunusoğlu, O. , Köse, Ç. , Shahzadi, A. , Özyazgan, S. , Demir, B. , Önal, B. , Akkan, A. G. "The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats" . Abant Tıp Dergisi 11 (2022 ): 231-242 <https://dergipark.org.tr/tr/pub/abantmedj/issue/72077/1120849>
Chicago Yunusoğlu, O. , Köse, Ç. , Shahzadi, A. , Özyazgan, S. , Demir, B. , Önal, B. , Akkan, A. G. "The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats". Abant Tıp Dergisi 11 (2022 ): 231-242
RIS TY - JOUR T1 - Sıçanlarda Bupropion ve Vareniklinin Morfin Yoksunluğu Sendromu Üzerine Etkileri AU - OruçYunusoğlu, ÇaglaKöse, AndleebShahzadi, SibelÖzyazgan, BülentDemir, BurakÖnal, Ahmet GökhanAkkan Y1 - 2022 PY - 2022 N1 - doi: 10.47493/abantmedj.1120849 DO - 10.47493/abantmedj.1120849 T2 - Abant Tıp Dergisi JF - Journal JO - JOR SP - 231 EP - 242 VL - 11 IS - 2 SN - 1305-4392-2147-1800 M3 - doi: 10.47493/abantmedj.1120849 UR - https://doi.org/10.47493/abantmedj.1120849 Y2 - 2022 ER -
EndNote %0 Abant Tıp Dergisi The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats %A Oruç Yunusoğlu , Çagla Köse , Andleeb Shahzadi , Sibel Özyazgan , Bülent Demir , Burak Önal , Ahmet Gökhan Akkan %T The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats %D 2022 %J Abant Tıp Dergisi %P 1305-4392-2147-1800 %V 11 %N 2 %R doi: 10.47493/abantmedj.1120849 %U 10.47493/abantmedj.1120849
ISNAD Yunusoğlu, Oruç , Köse, Çagla , Shahzadi, Andleeb , Özyazgan, Sibel , Demir, Bülent , Önal, Burak , Akkan, Ahmet Gökhan . "The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats". Abant Tıp Dergisi 11 / 2 (Ağustos 2022): 231-242 . https://doi.org/10.47493/abantmedj.1120849
AMA Yunusoğlu O. , Köse Ç. , Shahzadi A. , Özyazgan S. , Demir B. , Önal B. , Akkan A. G. The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats. Abant Med J. 2022; 11(2): 231-242.
Vancouver Yunusoğlu O. , Köse Ç. , Shahzadi A. , Özyazgan S. , Demir B. , Önal B. , Akkan A. G. The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats. Abant Tıp Dergisi. 2022; 11(2): 231-242.
IEEE O. Yunusoğlu , Ç. Köse , A. Shahzadi , S. Özyazgan , B. Demir , B. Önal ve A. G. Akkan , "The Effects of Bupropion and Varenicline on Morphine Withdrawal Syndrome in Rats", Abant Tıp Dergisi, c. 11, sayı. 2, ss. 231-242, Ağu. 2022, doi:10.47493/abantmedj.1120849