Olgu serisi: Ailesel Akdeniz ateşi ve ankilozan spondilit: nadir bir birliktelik

Yıl 2018, Cilt: 3 Sayı: 1, 26 - 28, 02.03.2018

Rabia Aydoğan Baykara Nevsun Pıhtılı Taş

https://doi.org/10.25000/acem.378500

Öz

Ailesel Akdeniz ateşi hastalığı ile birlikte olan bazı seronegatif spondiloartrit vakaları, ankilozan spondilit klinik seyri gösterebilir. Literatürde sakroileit ile ailesel Akdeniz ateşi birlikteliği ile ilgili sınırlı sayıda yayına rastlanmaktadır.  Bu çalışmada Şubat 2015 ile Ekim 2016 dönemi arasında ailesel Akdeniz ateşi hastalığı tanısı ile takip edilen 60 hastadan, daha sonra ankilozan spondilit klinik ve radyolojik bulgularını gösteren dört olgu sunuldu. Bu olgu serisi ile ailesel Akdeniz ateşi tanılı hastalarda sakroileit lehine değerlendirilebilecek bel ağrısı ve gluteal ağrı klinik bulgularının olması halinde, ankilozan spondilit birlikteliğinden şüphelenilmesine vurgu yapılması amaçlandı.

Anahtar Kelimeler

Ankilozan spondilit, Ailesel Akdeniz ateşi

Case Series: Familial Mediterranean fever and ankylosing spondylitis: A rare togetherness

Öz

Some seronegative spondyloarthritis cases with familial Mediterranean fever disease, ankylosing spondylitis may show clinical course. There are a limited number of publications in the literature regarding the association of sacroiliitis with Familial Mediterranean fever. In this study, four patients with clinical and radiological findings of ankylosing spondylitis were presented from 60 patients followed by familial Mediterranean fever between February 2015 and October 2016. It was aimed to emphasize the suspicion of ankylosing spondylitis in patients with familial Mediterranean fever with this case series, in case of clinical signs of gluteal pain and low back pain which can be evaluated in favor of sacroiliitis.

Anahtar Kelimeler

Ankylosing spondylitis, Familial Mediterranean fever

Kaynakça

• 1. Ben-Chetrit E, Levy M. Familial Mediterranean Fever. Lancet. 1998;351:659-64.
• 2. Aksentiyevich I, Pras E, Gruberg L, Shen Y. Sutherland G. Refined mapping of the gene causing familial Mediterranean fever by linkage and homozygosity studies. Am Hum Genet. 1993;53:451-61.
• 3. Mor A, Gal R, Livneh A. Abdominal and digestive system associations of familial Mediterranean fever. Am J Gastroenterol. 2003;98:2594-604.
• 4. Tunca M, Akar S, Onen F, Özdogan H, Kasapcopur O, Yalçınkaya F, et al. Turkish FMF Working Group Familial Mediterranean Fever in Turkey (FMF): The results of a multinational country study. Medicine (Baltimore). 2005;84:1-11.
• 5. Brik R, Shinawi M, Kasinetz L, Gershoni-Baruch R. Musculoskeletal findings of familial Mediterranean fever in children diagnosed with genetic disease. Artrit Rheum. 2001;44:1416-9.
• 6. El-Shanti H, Majeed HA, El-Khateeb M. Familial Mediterranean fever in Arabs. Lancet. 2006;367:1016-24.
• 7. Onen F, Akar S, Birlik M, Sari I, Khan MA, Gurler O, et al. Prevalence of ankylosing spondyloarthritis and related spondyloarthritides in an urban area of Izmir, Turkey. J Rheumatol. 2008;35:305-9.
• 8. Kausik P, El-Sobkie NI, Sheab D, Malaviya AN. Familial mediterranean fever with HLAB27 positive ankylosing spondylitis in a young Armenian man. Clin Exp Rheumatol. 1999;17:387-8.
• 9. Pras M, Kastner DL. Familial Mediterranean fever. In: Klippel JH, Dieppe PA, editors. Rheumatology. 2nd ed. London: Mosby; 1997. p.23.1–23.4
• 10. Ozgocmen S, Ozcakar L, Ardicoglu O, Karakoc E, Kaya A, Kiris A. Familial Mediterranean fever responds well to infliximab: single case experience. Clin Rheumatol. 2006;25:83-7.
• 11. Korkmaz C, Özdoğan H, Kasapçopur O, Yazici H. Acute phase response in familial Mediterranean fever. Ann Rheum Dis. 2002;61:79-81.
• 12. Majeed HA, Rawashdeh M. The clinical patterns of arthritis in children with familial Mediterranean fever. QJM. 1997;90:37-43.
• 13. Avci Köksal S, Dogan N, Koçyigit H, Gürgan A. A Familial Mediterranean Fever Associated with Ankylosing Spondylitis. Rheumatism. 2005;20:43-7.
• 14. Langevitz P, Livneh A, Zemer D, Shemer J, Pras M. Seronegative spondyloarthropathy in familial Mediterranean fever. Semin Arthritis Rheum. 1997;27:67–72.
• 15. Kaşifoğlu T, Calişir C, Cansu DU, Korkmaz C. Role of HLA-B27 and MEFV mutations in the development of sacroiliitis frequency and sacroiliitis in familial Mediterranean fever. Clin Rheumatol. 2009;28:41-6.