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Can seasonal differences affective on frequency and mortality of pulmonary embolism?

Year 2025, Volume: 7 Issue: 5, 665 - 669, 15.09.2025
https://doi.org/10.38053/acmj.1721428

Abstract

Aims: Does a seasonal variation in the incidence of pulmonary embolism (PE) exist? The aim of our study is to assess seasonal variation in the incidence of PE and to determine whether there are any differences in mortality.
Methods: Medical documentation of 402 patients diagnosed as acute PE in the five-year period were retrospectively analyzed. The study included patients aged 18 years and older with a diagnosis of PE confirmed by spiral thorax computed tomography.
Results: The highest numbers of case were seen in spring (n=115, 28.6%). In terms of months, the greatest number of cases occurred in November (n=48, 11.9%) and April (n=47, 11.7%). Case distribution according to seasons and months were statistically significant (p<0.001). No seasonal differences in mortality rates were observed (p=0.663). Only the distribution of white blood cell (WBC) level by the seasons was statistically significant among the recorded numerical data (p=0.045). The differences in mortality rates by numerical data (age, WBC, neutrophil, lymphocyte, platelet, D-dimer, CRP, PAB values, sPESI and Wells scores) were statistically significant.
Conclusion: Our observation that seasonal differences affective on frequency of PE has been confirmed.

References

  • Arseven O, Bayındır Ü, Yıldırım N, et al. Venöz Tromboembolizm. Arseven O (ed). Temel akciğer sağlığı ve hastalıkları. 2. İstanbul: Nobel Tıp Kitabevleri; 2015.
  • Guidelines on the diagnosis and management of acute pulmonary embolism. Task force on pulmonary embolism, European Society of Cardiology. Eur Heart J. 2000;21(16):1301-1336. doi:10.1053/euhj.2000.2250
  • Van Belle A, Buller HR, Huisman MV, et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA. 2006; 295(2):172-179. doi:10.1001/jama.295.2.172
  • Türk Toraks Derneği; Pulmoner tromboembolizm tanı ve tedavi uzlaşı raporu. 2015.
  • Meral M, Mirici A, Aslan S, et al. Barometric pressure andthe incidence of pulmonary embolism. Chest. 2005;128(4):2190-2194. doi:10.1378/chest.128.4.2190
  • Perincek G. Pulmoner Tromboemboli sıklığı ve mortalitesinin meteorolojik parametreler ile ilişkisi. Uzmanlık Tezi. Edirne: Trakya Üniversitesi, 2009.
  • Oztuna F, Ozsu S, Topbas M, Bülbül Y, Koşucu P, Ozlü T. Meteorological parameters and seasonal variations in pulmonary thromboembolism. Am J Emerg Med. 2008;26(9):1035-1041. doi:10.1016/j.ajem.2007.12.010
  • Anar C, Inal T, Erol S, et al. Are meteorological parameters a risk factor for pulmonary embolism? A retrospective analysis of 530 patients. Balkan Med J. 2015;32(3):279-284. doi:10.5152/balkanmedj.2015.15686
  • Ercan I, Coskun F, Cangur S, et al. An analysis of patients diagnosed with pulmonary embolism in terms of clinical and meteorological data. Saudi Med J. 2006;27(4):555-557.
  • Manfredini R, Gallerani M, Boari B, Salmi R, Mehta RH. Seasonal variation in onset of pulmonary embolism is independent of patients' underlying risk comorbid conditions. Clin Appl Thromb Hemost. 2004; 10(1):39-43. doi:10.1177/107602960401000106
  • Gallerani M, Boari B, Smolensky MH, et al. Seasonal variation in occurrence of pulmonary embolism: analysis of the database of the Emilia-Romagna region, Italy. Chronobiol Int. 2007;24(1):143-160. doi: 10.1080/07420520601139755
  • Guijarro R, Trujillo-Santos J, Bernal-Lopez MR, et al. Trend and seasonality in hospitalizations for pulmonary embolism: a time-series analysis. J Thromb Haemost. 2015;13(1):23-30. doi:10.1111/jth.12772
  • Stein PD, Kayali F, Beemath A, et al. Mortality from acute pulmonary embolism according to season. Chest. 2005;128(5):3156-3158. doi:10. 1378/chest.128.5.3156
  • Masotti L, Ceccarelli E, Forconi S, Cappelli R. Seasonal variations of pulmonary embolism in hospitalized patients. Respir Med. 2005;99(11): 1469-1473. doi:10.1016/j.rmed.2005.04.006

Can seasonal differences affective on frequency and mortality of pulmonary embolism?

Year 2025, Volume: 7 Issue: 5, 665 - 669, 15.09.2025
https://doi.org/10.38053/acmj.1721428

Abstract

Aims: Does a seasonal variation in the incidence of pulmonary embolism (PE) exist? The aim of our study is to assess seasonal variation in the incidence of PE and to determine whether there are any differences in mortality.
Methods: Medical documentation of 402 patients diagnosed as acute PE in the five-year period were retrospectively analyzed. The study included patients aged 18 years and older with a diagnosis of PE confirmed by spiral thorax computed tomography.
Results: The highest numbers of case were seen in spring (n=115, 28.6%). In terms of months, the greatest number of cases occurred in November (n=48, 11.9%) and April (n=47, 11.7%). Case distribution according to seasons and months were statistically significant (p<0.001). No seasonal differences in mortality rates were observed (p=0.663). Only the distribution of white blood cell (WBC) level by the seasons was statistically significant among the recorded numerical data (p=0.045). The differences in mortality rates by numerical data (age, WBC, neutrophil, lymphocyte, platelet, D-dimer, CRP, PAB values, sPESI and Wells scores) were statistically significant.
Conclusion: Our observation that seasonal differences affective on frequency of PE has been confirmed.

References

  • Arseven O, Bayındır Ü, Yıldırım N, et al. Venöz Tromboembolizm. Arseven O (ed). Temel akciğer sağlığı ve hastalıkları. 2. İstanbul: Nobel Tıp Kitabevleri; 2015.
  • Guidelines on the diagnosis and management of acute pulmonary embolism. Task force on pulmonary embolism, European Society of Cardiology. Eur Heart J. 2000;21(16):1301-1336. doi:10.1053/euhj.2000.2250
  • Van Belle A, Buller HR, Huisman MV, et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA. 2006; 295(2):172-179. doi:10.1001/jama.295.2.172
  • Türk Toraks Derneği; Pulmoner tromboembolizm tanı ve tedavi uzlaşı raporu. 2015.
  • Meral M, Mirici A, Aslan S, et al. Barometric pressure andthe incidence of pulmonary embolism. Chest. 2005;128(4):2190-2194. doi:10.1378/chest.128.4.2190
  • Perincek G. Pulmoner Tromboemboli sıklığı ve mortalitesinin meteorolojik parametreler ile ilişkisi. Uzmanlık Tezi. Edirne: Trakya Üniversitesi, 2009.
  • Oztuna F, Ozsu S, Topbas M, Bülbül Y, Koşucu P, Ozlü T. Meteorological parameters and seasonal variations in pulmonary thromboembolism. Am J Emerg Med. 2008;26(9):1035-1041. doi:10.1016/j.ajem.2007.12.010
  • Anar C, Inal T, Erol S, et al. Are meteorological parameters a risk factor for pulmonary embolism? A retrospective analysis of 530 patients. Balkan Med J. 2015;32(3):279-284. doi:10.5152/balkanmedj.2015.15686
  • Ercan I, Coskun F, Cangur S, et al. An analysis of patients diagnosed with pulmonary embolism in terms of clinical and meteorological data. Saudi Med J. 2006;27(4):555-557.
  • Manfredini R, Gallerani M, Boari B, Salmi R, Mehta RH. Seasonal variation in onset of pulmonary embolism is independent of patients' underlying risk comorbid conditions. Clin Appl Thromb Hemost. 2004; 10(1):39-43. doi:10.1177/107602960401000106
  • Gallerani M, Boari B, Smolensky MH, et al. Seasonal variation in occurrence of pulmonary embolism: analysis of the database of the Emilia-Romagna region, Italy. Chronobiol Int. 2007;24(1):143-160. doi: 10.1080/07420520601139755
  • Guijarro R, Trujillo-Santos J, Bernal-Lopez MR, et al. Trend and seasonality in hospitalizations for pulmonary embolism: a time-series analysis. J Thromb Haemost. 2015;13(1):23-30. doi:10.1111/jth.12772
  • Stein PD, Kayali F, Beemath A, et al. Mortality from acute pulmonary embolism according to season. Chest. 2005;128(5):3156-3158. doi:10. 1378/chest.128.5.3156
  • Masotti L, Ceccarelli E, Forconi S, Cappelli R. Seasonal variations of pulmonary embolism in hospitalized patients. Respir Med. 2005;99(11): 1469-1473. doi:10.1016/j.rmed.2005.04.006
There are 14 citations in total.

Details

Primary Language English
Subjects Chest Diseases
Journal Section Research Article
Authors

Şule Esen Karamişe 0000-0002-1915-2771

Şule Çilekar 0000-0001-8659-955X

Aydın Balcı 0000-0002-6723-2418

Gökhan Karamişe 0000-0003-2498-6794

Sibel Günay 0000-0001-6085-417X

Ersin Günay 0000-0002-2671-4584

Submission Date June 18, 2025
Acceptance Date September 4, 2025
Publication Date September 15, 2025
Published in Issue Year 2025 Volume: 7 Issue: 5

Cite

AMA Esen Karamişe Ş, Çilekar Ş, Balcı A, Karamişe G, Günay S, Günay E. Can seasonal differences affective on frequency and mortality of pulmonary embolism? Anatolian Curr Med J / ACMJ / acmj. September 2025;7(5):665-669. doi:10.38053/acmj.1721428

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