Romatoid artrit hastalarında venöz tromboembolizm riskinde hidroksiklorokinin ve komorbiditenin rolü: retrospektif bir vaka-kontrol çalışması

Year 2025, Volume: 7 Issue: 5, 597 - 601, 15.09.2025

Güllü Sandal Uzun , Ozan Yücel , Yunus Kaygusuz , Melda Bahap , Sedat Kiraz , İhsan Ertenli , Levent Kılıç , Umut Kalyoncu

https://doi.org/10.38053/acmj.1747743

Abstract

Giriş: Romatoid artrit (RA) hastaları, venöz tromboembolizm (VTE) açısından artmış risk altındadır. Bu çalışma, RA hastalarında VTE ile ilişkili klinik özellikleri ve tedaviyle ilişkili faktörleri belirlemeyi amaçlamaktadır.
Yöntemler: VTE'si belgelenmiş 34 RA hastası da dahil olmak üzere 363 RA hastasının retrospektif analizi gerçekleştirilmiştir. Demografik özellikler, eşlik eden hastalıklar ve tedavi verileri, VTE'si olan ve olmayan hastalar arasında karşılaştırılmıştır. VTE'nin bağımsız öngörücülerini belirlemek için yaş ve cinsiyete göre eşleştirilmiş alt grup analizi ve çok değişkenli lojistik regresyon kullanılmıştır.
Sonuçlar: VTE'si olan RA hastalarının ortalama yaşı 66,8 (11,5) olup, 30'u (88,2) kadındı. VTE, ileri yaş, hipertansiyon, hiperlipidemi ve daha yüksek Charlson Eşlik Eden Hastalık İndeksi (CCI) ile anlamlı şekilde ilişkiliydi. Çok değişkenli modelde, yüksek CCI, VTE ile bağımsız olarak ilişkiliydi (OR 2,84, %95 GA: 1,46-3,80, p < 0,001). Hidroksiklorokin kullanımı VTE ile negatif ilişkiliydi (OR 0,34, %95 GA: 0,10-0,86, p = 0,049). Diğer DMARD'lar ve glukokortikoidler bağımsız ilişki göstermedi.
Sonuç: Yüksek komorbidite yükü, RA hastalarında VTE riskini önemli ölçüde artırırken, hidroksiklorokin koruyucu bir etki gösterebilir. Bu bulgular, kişiye özel komorbidite yönetiminin önemini vurgulamakta ve hidroksiklorokinin RA'da trombozun önlenmesinde potansiyel bir rolü olabileceğini düşündürmektedir.

Keywords

Romatoid Artrit , Venöz Tromboembolizim , Hidroksiklorokin , Charlson Komorbidite İndexi

Comorbidity burden and the role of hydroxychloroquine in venous thromboembolism risk among rheumatoid arthritis patients: a retrospective case-control study

Abstract

Aims: Patients with rheumatoid arthritis (RA) are at increased risk for venous thromboembolism (VTE). This study aims to identify clinical characteristics and treatment-related factors associated with VTE in RA patients.
Methods: A retrospective analysis of 363 RA patients was conducted, including 34 RA patients with documented VTE. Demographics, comorbidities, and treatment data were compared between patients with and without VTE. Age-and sexmatched subgroup analysis and multivariate logistic regression were used to identify independent predictors of VTE.
Results: The mean age of RA patients with VTE was 66.8 (11.5) and 30 (88.2) were female. VTE was significantly associated with older age, hypertension, hyperlipidemia, and higher Charlson Comorbidity Index (CCI). In the multivariate model, higher CCI was independently associated with VTE (OR 2.84, 95% CI: 1.46–3.80, p<0.001). Hydroxychloroquine use was negatively associated with VTE (OR 0.34, 95% CI: 0.10–0.86, p=0.049). Other DMARDs and glucocorticoids did not show independent associations.
Conclusion: A high comorbidity burden significantly increases VTE risk in RA patients and HCQ use was associated with lower odds of VTE. These findings highlight the importance of individualized comorbidity management and suggest a potential role for hydroxychloroquine in thrombosis prevention in RA.

Keywords

Rheumatoid arthritis , venous thromboembolism , Charlson Comorbidity Index , hydroxychloroquine

Ethical Statement

The study was approved by “ the Ethics Committee of the Hacettepe University Faculty of Medicine” (No. GO: 21–1069; date: October 5, 2021).

Supporting Institution

None

Thanks

Dear Editor, 21/07/2025 We would like to submit our research article “Comorbidity Burden and the Role of Hydroxychloroquine in Venous Thromboembolism Risk Among Rheumatoid Arthritis Patients: A Retrospective Case-Control Study” for consideration to be published in  Anatolian Current Medical Journal . The manuscript has not been and will not be submitted to any other journal while it is under consideration by  Anatolian Current Medical Journal . Each individual named as an author meets the journal’s criteria for authorship. Each author listed on the manuscript has seen and approved the submission of this version of the manuscript and takes full responsibility for the manuscript. None of the authors received financial support, and no potential conflicts of interest exist for this work. Authors agree to bear the applicable publication charges if the manuscript is accepted for publication. Kindest regards, Gül Sandal UZUN, MD e-mail: [e-mail]

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