The diagnostic and prognostic role of the pan-immune-inflammation value in vestibular neuritis

Abstract

Aims: The aim of this study is to examine Pan-Immune-Inflammation Value (PIV) levels in patients with vestibular neuritis (VN) and to reveal the potential diagnostic and prognostic value of this marker. Methods: One hundred patients diagnosed with VN between October 1, 2023 and October 1, 2025 and 100 healthy individuals compatible with the patient group were included in the study. Patients’ demographic characteristic, complete blood count parameters at the time of presentation, and outpatient treatment or admission status were recorded by means of retrospective scanning of the hospital records. PIV, SII, NLR, and PLR values were calculated from complete blood count parameters. The results were compared among the groups. Results: No significant difference were observed between the two groups in terms of age or gender (p=0.921 and p=0.884 respectively). Comparison of laboratory parameters revealed a significantly higher neutrophil level in the VN group (p<0.001). However, no significant differences were determined in terms of platelet, monocyte, or lymphocyte values (p=0.481, p=0.243 and p=0.650 respectively). PIV, SII, and NLR were all significantly higher in the VN group (p<0.001). No difference was observed between the groups’ PLR values (p=0.547). ROC analysis revealed that PIV exhibited a moderate diagnostic performance in the differentiation of VN (AUC=0.694; 95% CI: 0.622-0.766). SII (AUC=0.672; 95% CI: 0.598-0.746) and NLR (AUC=0.655; 95% CI: 0.579-0.731) also showed fair diagnostic performance, while PLR performed poorly (AUC=0.525; 95% CI: 0.446-0.604). Correlation analysis revealed powerful positive correlations between PIV and SII (r=0.85; p<0.001) and NLR (r=0.70; p<0.001). However, only a weak positive correlation was observed between PIV and PLR (r=0.32; p=0.04). In logistic regression analysis, elevated PIV was independently associated with hospitalization requirement (OR=1.004; 95% CI: 1.000-1.008; p=0.031). Conclusion: This study shows that PIV is of both diagnostic and prognostic importance in VN. Capable of being calculated from routine complete blood count parameters, PIV can be employed as a simple, low-cost, and useful biomarker in treatment planning and clinical course prediction by reflecting inflammatory activity and disease severity in the early stages of VN.

Keywords

• Vestibular neuritis
• pan-immune-inflammation value
• inflammation
• prognosis

Vestibüler nöritte pan-immün-inflamasyon değerinin tanısal ve prognostik rolü

Abstract

Amaç: Bu çalışmanın amacı, vestibüler nöritli (VN) hastalarda Pan-İmmün İnflamasyon Değeri (PIV) düzeylerini incelemek ve bu belirtecin potansiyel tanısal ve prognostik değerini ortaya koymaktır. Yöntem: Ekim 2023 ile Ekim 2025 tarihleri ​​arasında VN tanısı almış 100 hasta ve hasta grubuyla uyumlu 100 sağlıklı birey çalışmaya dahil edildi. Hastaların demografik özellikleri, başvuru anındaki tam kan sayımı parametreleri ve ayaktan tedavi veya yatış durumları hastane kayıtlarının retrospektif olarak taranarak kaydedildi. Tam kan sayımı parametrelerinden PIV, SII, NLR ve PLR ​​değerleri hesaplandı. Sonuçlar gruplar arasında karşılaştırıldı. Bulgular: İki grup arasında yaş ve cinsiyet açısından anlamlı bir fark gözlenmedi (sırasıyla p=0.921, p=0.884). Laboratuvar parametrelerinin karşılaştırılmasında, VN grubunda nötrofil düzeyi anlamlı derecede daha yüksek bulundu (p<0.001). Ancak trombosit, monosit ve lenfosit değerleri açısından anlamlı bir fark saptanmadı (sırasıyla p=0.481, p=0.243, p=0.650). PIV, SII ve NLR, VN grubunda anlamlı derecede yüksekti (p<0.001). Grupların PLR değerleri arasında fark gözlenmedi (p=0.547). ROC analizi, PIV'in VN'yi ayırt etmede orta düzeyde tanısal performans gösterdiğini ortaya koydu (AUC=0.694). Korelasyon analizinde, PIV ile SII (r=0.85; p<0.001) ve NLR (r=0.70; p<0.001) arasında güçlü pozitif korelasyon izlendi. Lojistik regresyon analizinde, PIV yüksekliği ile hastaneye yatış gereksinimi arasında bağımsız ve anlamlı bir korelasyon izlendi (p=0.031). Sonuç: Bu çalışma, PIV'in VN'de hem tanısal hem de prognostik öneme sahip olduğunu göstermektedir. Rutin tam kan sayımı parametrelerinden hesaplanabilen PIV, VN'nin erken dönemlerinde inflamatuvar aktiviteyi ve hastalık şiddetini yansıtarak tedavi planlamasında ve klinik seyri öngörmede basit, düşük maliyetli ve yararlı bir biyobelirteç olarak kullanılabilir.

Keywords

• vestibüler nörit
• pan-immün-inflamasyon değeri
• inflamasyon
• prognoz

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