Araştırma Makalesi
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Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes

Yıl 2025, Cilt: 9 Sayı: 3, 277 - 283, 22.12.2025
https://doi.org/10.46332/aemj.1616577

Öz

Purpose: Gestational Diabetes Mellitus (GDM) is the disorder of glucose regulation of pregnant women. Its frequency is increas-ing in the world and in our country. Women with GDM are also at risk for Type 2 Diabetes Mellitus (T2 DM). The aim of this retrospective cohort study was to evaluate the prevalence of GDM and the risk of developing Type 2 DM after delivery in preg-nant women attended routine pregnancy follow-ups in the Internal Medicine and Obstetrics Clinic of Ümraniye Education and Research Hospital between December 2012 and November 2017.

Materials and Methods: Data of 32.857 pregnant women were examined from December 2012 to November 2017. 1.108 women with positive GDM results were identified with glucose tolerance tests. Complete medical records of 300 pregnant women were documented for their demographic characteristics. Furthermore, the 5-year postpartum period of these patients was analyzed to identify those who developed Type 2 DM.

Results: Hospital data showed a GDM prevalence of 3.37% and an average maternal age of 32.49 years (18-48). Notably, 21% (63 patients) of the GDM group developed Type 2 DM, diagnosed on average 3.1 years later (2-5 years range).

Conclusion: The GDM prevalence in our study aligns with data from Turkey and worldwide. Our findings highlights the increased risk of T2DM in patients with a history of GDM and a significant association between advanced maternal age and GDM prevalence. Implementing public health policies focusing on life style modifications and awareness campaigns may help reduce GDM incidence and its long-term complications.

Etik Beyan

Approval for this study was obtained from the Clinical Research Ethics Committee of Ümraniye Training and Research Hospital (21.12.2017 date and B.10.1.TKH.4.34.H.GP.0.01/138 number).

Teşekkür

This manuscript is based on the first author's PhD thesis project and was presented at the International Congress of Academic Research (ICAR), January 2022.

Kaynakça

  • 1. Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843.
  • 2. Buchanan TA, Xiang AH, Page KA. Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol. 2012;8(11):639–649.
  • 3. Butte NF. Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus. Am J Clin Nutr. 2000;71(5):1256S–1261S.
  • 4. Çoban A. Riskli Gebelikler. In: Şirin A, Kavlak O, eds. Kadın Sağlığı. Ankara: Nobel Tıp Kitabevi: 2015:324.
  • 5. ElSayed NA, Aleppo G, Aroda VR, et al. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(1):19-40.
  • 6. ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus. Obstet Gynecol. 2018;131(2):49-64.
  • 7. Mazze RS, Krogh CL. Gestational diabetes mellitus: now is the time for detection and treatment. Mayo Clin Proc. 1992;67(10):995-1002.
  • 8. International Diabetes Federation. IDF Diabetes Atlas. 7th ed. Brussels: IDF; 2015. Available from: https://www.diabetesatlas.org/resources/previous-editions/ (Accessed 19 November 2025)
  • 9. Venkatesh KK, Lynch CD, Powe CE, et al. Risk of Adverse Pregnancy Outcomes Among Pregnant Individuals With Gestational Diabetes by Race and Ethnicity in the United States, 2014-2020. JAMA. 2022;327(14):1356-1367.
  • 10. Ye W, Luo C, Huang J, Li C, Liu Z, Liu F. Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2022;377:067946.
  • 11. Farrar D, Simmonds M, Bryant M, et al. Hyperglycaemia and risk of adverse perinatal outcomes: systematic review and meta-analysis. BMJ. 2016;354:4694.
  • 12. Rodrigues S, Robinson E, Gray-Donald K. Prevalence of gestational diabetes mellitus among James Bay Cree women in northern Quebec. CMAJ. 1999;160(9):1293-1297.
  • 13. Vounzoulaki E, Khunti K, Abner SC, Tan BK, Davies MJ, Gillies CL. Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis. BMJ. 2020;369:1361.
  • 14. DeFronzo RA, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care. 2009;32(Suppl 2):S157–S163.
  • 15. Metzger BE, Gabbe SG, Persson B et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676-682.
  • 16. Ayaz A, Saeed S, Farooq MU, Bahoo MLA, Hanif K. Gestational diabetes mellitus diagnosed in different periods of gestation and neonatal outcome. Dicle Med J. 2009;36(4):235-240.
  • 17. Tanir HM, Sener T, Gürer H, Kaya M. A ten-year gestational diabetes mellitus cohort at a university clinic of the mid-Anatolian region of Turkey. Clin Exp Obstet Gynecol. 2005;32(4):241-244.
  • 18. Oğuzöncül AF, Güngör Y, Açık Y, et al. Elazığ Yenimahalle Eğitim ve Araştırma Sağlık Ocağına bağlı populasyona ait gebelerde gebelik diyabeti taraması. Selcuk Med J. 2003;19(2):61-64.
  • 19. Erem C, Cihanyurdu N, Deger O, Karahan C, Can G, Telatar M. Screening for gestational diabetes mellitus in northeastern Turkey (Trabzon City). Eur J Epidemiol. 2003;18(1):39-43.
  • 20. Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373(9677):1773-1779.
  • 21. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization Guideline. Diabetes Res Clin Pract. 2014;103(3):341-363.
  • 22. Bian X, Gao P, Xiong X, Xu H, Qian M, Liu S. Risk factors for development of diabetes mellitus in women with a history of gestational diabetes mellitus. Chin Med J. 2000;113(8):759-762.
  • 23. Lauenborg J, Hansen T, Jensen DM, et al. Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population. Diabetes Care. 2004;27(5):1194-1199.
  • 24. Marquette GP, Klein VR, Repke JT, Niebyl JR. Cost-effective criteria for glucose screening. Obstet Gynecol. 1985;66(2):181-184.
  • 25. O'Sullivan JB, Mahan CM, Charles D, Dandrow RV. Screening criteria for high-risk gestational diabetic patients. Am J Obstet Gynecol. 1973;116(7):895-900.
  • 26. Marquette GP, Klein VR, Niebyl JR. Efficacy of screening for gestational diabetes. Am J Perinatol. 1985;2(1):7-9.
  • 27. Capula C, Mazza T, Vero R, Costante G. HbA1c levels in patients with gestational diabetes mellitus: Relationship with pre-pregnancy BMI and pregnancy outcome. J Endocrinol Invest. 2013;36(11):1038-1045.
  • 28. Bakiner O, Bozkirli E, Ozsahin K, Sariturk C, Ertorer E. Risk Factors That can Predict Antenatal Insulin Need in Gestational Diabetes. J Clin Med Res. 2013;5(5):381-388.
  • 29. Yong HY, Mohd Shariff Z, Mohd Yusof BN, et al. Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus. Sci Rep. 2020;10(1):8486.

Hastane Gestasyonel Diyabet Prevelansının Retrospektif Belirlenmesi ve Tip 2 Diyabet Geliştirme Riski

Yıl 2025, Cilt: 9 Sayı: 3, 277 - 283, 22.12.2025
https://doi.org/10.46332/aemj.1616577

Öz

Amaç: Gestasyonel Diyabetus Mellitus (GDM), gebelerde glukoz regülasyonunun bozulmasına denir. Dünyada ve ülkemizde sıklığı giderek artmaktadır. GDM’li kadınlar Tip 2 Diabetes Mellitus (T2 DM) açısındanda risk altındadırlar. Bu retrospektif kohort çalışmanın amacı, Ümraniye Eğitim ve Araştırma Hastanesi Aralık 2012 ile Kasım 2017 arasındaki dönemde Dahiliye ve Doğum Kliniği'nde rutin gebelik takiplerine katılan gebelerde GDM prevalansını ve doğum sonrası Tip 2 DM gelişme riskini değerlendirmektir.

Araçlar ve Yöntem: Aralık 2012- Kasım 2017 tarihleri arasından seçilmiş 32.857 gebe kadının verileri incelendi. Glukoz yükleme testleri sonucu GDM pozitif olan 1.108 kadın tespit edildi.Tıbbi kayıtları eksiksiz olan 300 gebe demografik özellikleri ile belgelendi.Ayrıca Tip 2 DM geliştirenleri belirlemek için bu hastaların doğum sonrası 5 yıllık süreci analiz edildi.

Bulgular: Hastane verilerimizde GDM prevalansının %3.37 olduğu ve ortalama anne yaşının 32.49 (18-48) olduğu görüldü. Özellikle GDM grubunun %21'inde (63 hasta), ortalama 3.1 yıl sonra (2-5 yıl aralığı) teşhis edilen Tip 2 DM gelişmiştir.

Sonuç: Çalışmamızdaki GDM prevalansı Türkiye ve dünya çapındaki verilerle uyumludur. Bulgularımız GDM öyküsü olan hastalarda T2DM riskinin arttığını ve ileri anne yaşı ile GDM prevalansı arasında önemli bir ilişki olduğunu vurgulamaktadır. Yaşam tarzı değişikliklerine ve farkındalık kampanyalarına odaklanan halk sağlığı politikalarının uygulanması GDM insidansını ve uzun vadeli komplikasyonlarını azaltmaya yardımcı olabilir.

Etik Beyan

Bu çalışma için Ümraniye Eğitim ve Araştırma Hastanesi Klinik Araştırmalar Etik Kurulu’ndan onay alındı ​​(21.12.2017 tarih ve B.10.1.TKH.4.34.H.GP.0.01/138 nolu).

Teşekkür

Bu makale, ilk yazarın doktora tez projesine dayanmaktadır ve Ocak 2022'de Uluslararası Akademik Araştırma Kongresi'nde (ICAR) sunulmuştur.

Kaynakça

  • 1. Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843.
  • 2. Buchanan TA, Xiang AH, Page KA. Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol. 2012;8(11):639–649.
  • 3. Butte NF. Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus. Am J Clin Nutr. 2000;71(5):1256S–1261S.
  • 4. Çoban A. Riskli Gebelikler. In: Şirin A, Kavlak O, eds. Kadın Sağlığı. Ankara: Nobel Tıp Kitabevi: 2015:324.
  • 5. ElSayed NA, Aleppo G, Aroda VR, et al. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(1):19-40.
  • 6. ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus. Obstet Gynecol. 2018;131(2):49-64.
  • 7. Mazze RS, Krogh CL. Gestational diabetes mellitus: now is the time for detection and treatment. Mayo Clin Proc. 1992;67(10):995-1002.
  • 8. International Diabetes Federation. IDF Diabetes Atlas. 7th ed. Brussels: IDF; 2015. Available from: https://www.diabetesatlas.org/resources/previous-editions/ (Accessed 19 November 2025)
  • 9. Venkatesh KK, Lynch CD, Powe CE, et al. Risk of Adverse Pregnancy Outcomes Among Pregnant Individuals With Gestational Diabetes by Race and Ethnicity in the United States, 2014-2020. JAMA. 2022;327(14):1356-1367.
  • 10. Ye W, Luo C, Huang J, Li C, Liu Z, Liu F. Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2022;377:067946.
  • 11. Farrar D, Simmonds M, Bryant M, et al. Hyperglycaemia and risk of adverse perinatal outcomes: systematic review and meta-analysis. BMJ. 2016;354:4694.
  • 12. Rodrigues S, Robinson E, Gray-Donald K. Prevalence of gestational diabetes mellitus among James Bay Cree women in northern Quebec. CMAJ. 1999;160(9):1293-1297.
  • 13. Vounzoulaki E, Khunti K, Abner SC, Tan BK, Davies MJ, Gillies CL. Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis. BMJ. 2020;369:1361.
  • 14. DeFronzo RA, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care. 2009;32(Suppl 2):S157–S163.
  • 15. Metzger BE, Gabbe SG, Persson B et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676-682.
  • 16. Ayaz A, Saeed S, Farooq MU, Bahoo MLA, Hanif K. Gestational diabetes mellitus diagnosed in different periods of gestation and neonatal outcome. Dicle Med J. 2009;36(4):235-240.
  • 17. Tanir HM, Sener T, Gürer H, Kaya M. A ten-year gestational diabetes mellitus cohort at a university clinic of the mid-Anatolian region of Turkey. Clin Exp Obstet Gynecol. 2005;32(4):241-244.
  • 18. Oğuzöncül AF, Güngör Y, Açık Y, et al. Elazığ Yenimahalle Eğitim ve Araştırma Sağlık Ocağına bağlı populasyona ait gebelerde gebelik diyabeti taraması. Selcuk Med J. 2003;19(2):61-64.
  • 19. Erem C, Cihanyurdu N, Deger O, Karahan C, Can G, Telatar M. Screening for gestational diabetes mellitus in northeastern Turkey (Trabzon City). Eur J Epidemiol. 2003;18(1):39-43.
  • 20. Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373(9677):1773-1779.
  • 21. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization Guideline. Diabetes Res Clin Pract. 2014;103(3):341-363.
  • 22. Bian X, Gao P, Xiong X, Xu H, Qian M, Liu S. Risk factors for development of diabetes mellitus in women with a history of gestational diabetes mellitus. Chin Med J. 2000;113(8):759-762.
  • 23. Lauenborg J, Hansen T, Jensen DM, et al. Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population. Diabetes Care. 2004;27(5):1194-1199.
  • 24. Marquette GP, Klein VR, Repke JT, Niebyl JR. Cost-effective criteria for glucose screening. Obstet Gynecol. 1985;66(2):181-184.
  • 25. O'Sullivan JB, Mahan CM, Charles D, Dandrow RV. Screening criteria for high-risk gestational diabetic patients. Am J Obstet Gynecol. 1973;116(7):895-900.
  • 26. Marquette GP, Klein VR, Niebyl JR. Efficacy of screening for gestational diabetes. Am J Perinatol. 1985;2(1):7-9.
  • 27. Capula C, Mazza T, Vero R, Costante G. HbA1c levels in patients with gestational diabetes mellitus: Relationship with pre-pregnancy BMI and pregnancy outcome. J Endocrinol Invest. 2013;36(11):1038-1045.
  • 28. Bakiner O, Bozkirli E, Ozsahin K, Sariturk C, Ertorer E. Risk Factors That can Predict Antenatal Insulin Need in Gestational Diabetes. J Clin Med Res. 2013;5(5):381-388.
  • 29. Yong HY, Mohd Shariff Z, Mohd Yusof BN, et al. Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus. Sci Rep. 2020;10(1):8486.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Endokrinoloji, İç Hastalıkları, Klinik Tıp Bilimleri (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Murat Doğan 0000-0003-0776-3644

Birgul Deniz Dogan 0000-0002-9197-2459

Sema Uçak Basat 0000-0002-6479-1644

Gönderilme Tarihi 9 Ocak 2025
Kabul Tarihi 9 Nisan 2025
Yayımlanma Tarihi 22 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 9 Sayı: 3

Kaynak Göster

APA Doğan, M., Deniz Dogan, B., & Uçak Basat, S. (2025). Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes. Ahi Evran Medical Journal, 9(3), 277-283. https://doi.org/10.46332/aemj.1616577
AMA Doğan M, Deniz Dogan B, Uçak Basat S. Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes. Ahi Evran Medical Journal. Aralık 2025;9(3):277-283. doi:10.46332/aemj.1616577
Chicago Doğan, Murat, Birgul Deniz Dogan, ve Sema Uçak Basat. “Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes”. Ahi Evran Medical Journal 9, sy. 3 (Aralık 2025): 277-83. https://doi.org/10.46332/aemj.1616577.
EndNote Doğan M, Deniz Dogan B, Uçak Basat S (01 Aralık 2025) Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes. Ahi Evran Medical Journal 9 3 277–283.
IEEE M. Doğan, B. Deniz Dogan, ve S. Uçak Basat, “Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes”, Ahi Evran Medical Journal, c. 9, sy. 3, ss. 277–283, 2025, doi: 10.46332/aemj.1616577.
ISNAD Doğan, Murat vd. “Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes”. Ahi Evran Medical Journal 9/3 (Aralık2025), 277-283. https://doi.org/10.46332/aemj.1616577.
JAMA Doğan M, Deniz Dogan B, Uçak Basat S. Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes. Ahi Evran Medical Journal. 2025;9:277–283.
MLA Doğan, Murat vd. “Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes”. Ahi Evran Medical Journal, c. 9, sy. 3, 2025, ss. 277-83, doi:10.46332/aemj.1616577.
Vancouver Doğan M, Deniz Dogan B, Uçak Basat S. Retrospective Determination of Hospital Gestational Diabetes Prevalence and the Risk of Developing Type 2 Diabetes. Ahi Evran Medical Journal. 2025;9(3):277-83.

Dergimiz, ULAKBİM TR Dizin, DOAJ, Index Copernicus, EBSCO ve Türkiye Atıf Dizini (Turkiye Citation Index)' de indekslenmektedir. Ahi Evran Tıp dergisi süreli bilimsel yayındır. Kaynak gösterilmeden kullanılamaz. Makalelerin sorumlulukları yazarlara aittir.

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