Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats

Fatih Mehmet Kandemir; Hasan Şimşek

Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats

Abstract

Introduction: This study aimed to determine the protective effect of Rutin on Colistin-induced sciatic nerve injury. Methods: Thirty-five rats were divided into five groups: control, Rutin, Colistin, Colistin+Rutin50, and Colistin+Rutin100. Biochemically, malondialdehyde (MDA), glial fibrillary acidic protein (GFAP), nerve cell adhesion molecule (NCAM), nuclear factor kappa B (NF-κB), cyclooxygenase 2 (COX-2), and neuronal nitric oxide synthase (nNOS), and parameters were analyzed. Results: Colistin treatment caused sciatic nerve injury by increasing MDA levels (p < 0.05) leading to lipid peroxidation; by increasing COX-2, NF-κB, and nNOS levels (p < 0.05) leading to inflammation; and by increasing GFAP levels and decreasing NCAM levels (p < 0.05). Colistin+Rutin50 and Colistin+Rutin100 treatments were found to have therapeutic effects against sciatic nerve injury by decreasing MDA levels and lipid peroxidation, decreasing NF-κB, COX-2, and nNOS levels and inflammation, decreasing GFAP levels, and increasing NCAM levels. Conclusion: Overall, Rutin was found to have a therapeutic effect against Colistin-induced sciatic nerve injury.

Keywords

References

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Details

Primary Language

English

Subjects

Medical Biochemistry and Metabolomics (Other)

Journal Section

Research Article

Authors

Fatih Mehmet Kandemir ^*
0000-0002-8490-2479
Türkiye

Hasan Şimşek
0000-0001-5573-4923
Türkiye

Publication Date

September 30, 2025

Submission Date

August 28, 2025

Acceptance Date

September 18, 2025

Published in Issue

Year 2025 Volume: 1 Number: 1

IZ

https://izlik.org/JA53BE23FN

Cite

RIS / Bibtex

APA

Kandemir, F. M., & Şimşek, H. (2025). Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats. Anatolian Journal of Medical Sciences, 1(1), 29-35. https://izlik.org/JA53BE23FN

AMA

1.Kandemir FM, Şimşek H. Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats. Anatolian Journal of Medical Sciences. 2025;1(1):29-35. https://izlik.org/JA53BE23FN

Chicago

Kandemir, Fatih Mehmet, and Hasan Şimşek. 2025. “Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats”. Anatolian Journal of Medical Sciences 1 (1): 29-35. https://izlik.org/JA53BE23FN.

EndNote

Kandemir FM, Şimşek H (September 1, 2025) Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats. Anatolian Journal of Medical Sciences 1 1 29–35.

IEEE

[1]F. M. Kandemir and H. Şimşek, “Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats”, Anatolian Journal of Medical Sciences, vol. 1, no. 1, pp. 29–35, Sept. 2025, [Online]. Available: https://izlik.org/JA53BE23FN

ISNAD

Kandemir, Fatih Mehmet - Şimşek, Hasan. “Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats”. Anatolian Journal of Medical Sciences 1/1 (September 1, 2025): 29-35. https://izlik.org/JA53BE23FN.

JAMA

1.Kandemir FM, Şimşek H. Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats. Anatolian Journal of Medical Sciences. 2025;1:29–35.

MLA

Kandemir, Fatih Mehmet, and Hasan Şimşek. “Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats”. Anatolian Journal of Medical Sciences, vol. 1, no. 1, Sept. 2025, pp. 29-35, https://izlik.org/JA53BE23FN.

Vancouver

1.Fatih Mehmet Kandemir, Hasan Şimşek. Investigation of the Effects of Rutin on Sciatic Nerve Damage Induced by Colistin in Rats. Anatolian Journal of Medical Sciences [Internet]. 2025 Sep. 1;1(1):29-35. Available from: https://izlik.org/JA53BE23FN