Araştırma Makalesi
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Yıl 2020, Cilt: 26 Sayı: 1, 8 - 11, 05.03.2020
https://doi.org/10.15832/ankutbd.451099

Öz

Kaynakça

  • Cases S, Smith S J, Zheng Y W, Myers H M, Lear S R, Sande E, Novak S, Collins C, Welch C B, Lusis A J, Erickson S K & Farese Jr R V (1998). Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. USA 95: 13018-13023.
  • Coppieters W, Riquet J, Arranz J J, Berzi P, Cambisano N, Grisart B, Karim L, Marcq F, Moreau L, Nezer C, Simon P, Vanmanshoven P, Wagenaar D & Georges M (1998). A QTL with major effect on milk yield and composition maps to bovine chromosome 14. Mamm. Genome 9: 540-544.
  • Gautier M, Capitan A, Fritz S, Eggen A, Boichard D & Druet T (2007). Characterization of the DGAT1 K232A and variable number of tandem repeat polymorphisms in French dairy cattle. J Dairy Sci. 90: 2980–2988.
  • Grisart B, Coppieters W, Farnir F, Karim L, Ford C, Berzi P, Cambisano N, Mni M, Reid S, Simon P, Spelman R, Georges M & Snell R (2002). Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res. 12: 222-231.
  • Grisart B, Farnir F, Karim L, Cambisano N, Kim J J, Alex K, Mni M, Simon P, Frère J-M, Coppieters & Georges M (2004). Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proc. Natl. Acad. Sci. USA 101: 2398-2403.
  • Kaupe B, Winter A, Fries R, Erhardt G (2004). DGAT1 polymorphism in Bos indicus and Bos Taurus cattle breeds. J. Dairy Res. 71: 182–187Özdil, F & İlhan F (2012) DGAT1-exon 8 polymorphism in Anatolian buffalo. Livestock Science 149: 83-87.
  • Salimei E, Fantuz F, Coppola R, Chiofalo B, Polidori P & Varisco G (2004). Composition and characteristics of ass’s milk. Animal Research 53: 67-78.
  • Sambrook J, Fritsch E F, Maniatis T (1989). Molecular cloning: A laboratory Manual, vol. 3, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Schennink A, Stoop W M, Visker M H P W, Heck J M L, Bovenhuis H, van der Poel J J, van Valenberg H J F & van Arendonk J A M (2007). DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Animal Genetics 38: 467-473.
  • Smith S J, Cases S, Jensen D R, Chen H C, Sande E, Tow B, Sanan D A, Raber J, Eckel R H & Farese R V.Jr (2000). Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25: 87-90.
  • Spelman R J, Ford C A, McElhinney P, Gregory G C & Snell R G (2002). Characterization of the DGAT1 gene in the New Zealand dairy population. J. Dairy Sci. 85: 3514–3517.
  • Weller J I, Golik M, Seroussi E, Ezra E & Ron M (2003). Population-wide analysis of a QTL affecting milk-fat production in the Israeli Holstein population. J. Dairy Sci. 86: 2219–2227.
  • Thaller G, Krämer W, Winter A, Kaupe B, Erhardt G & Fries R (2003). Effects of DGAT1 variants on milk production traits in German cattle breeds J. Anim. Sci. 81:1911-1918.
  • Winter A, Kramer W, Werner F A O, Kollers S, Kata S, Durstewitz G, Buitkamp J, Womack J E, Thaller G & Fries R (2002). Association of a lysine-232⁄ alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Proc. Natl. Acad. Sci. USA 99: 9300-9305.

The Genetic Characterization of DGAT1 Gene in Donkey Populations Reared in Thrace Region of Turkey

Yıl 2020, Cilt: 26 Sayı: 1, 8 - 11, 05.03.2020
https://doi.org/10.15832/ankutbd.451099

Öz

AcylCoA: diacylglycerol acyltransferase (DGAT1) gene has a considerable effect on milk content and yield in cattle with a substitution of lysine by alanine in the exon 8 of the gene. Moreover there are many other researches comprising the DGAT1 gene on different farm animals, such as buffalo, sheep and goat but there is no information about the DGAT1 gene in donkeys. In this study, the polymorphism of DGAT1 gene in donkey populations reared in Thrace region of Turkey has been investigated by restriction fragment length polymorphism (RFLP) via EaeI (CfrI) restriction enzyme. EaeI restriction site was found in cattle breeds which resulted after K232A substitution, Lysine (AAG) to Alanine (GCG) variant but this restriction site was not found in donkey populations. A novel single-nucleotide polymorphism (GA substitution) in the DGAT1 gene at position 10,435 lacks this restriction site which results only Alanine variant (GCA) instead of Lysine variant. This novel single-nucleotide polymorphism in the DGAT1 gene was found in the studied donkey breeds.

Kaynakça

  • Cases S, Smith S J, Zheng Y W, Myers H M, Lear S R, Sande E, Novak S, Collins C, Welch C B, Lusis A J, Erickson S K & Farese Jr R V (1998). Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. USA 95: 13018-13023.
  • Coppieters W, Riquet J, Arranz J J, Berzi P, Cambisano N, Grisart B, Karim L, Marcq F, Moreau L, Nezer C, Simon P, Vanmanshoven P, Wagenaar D & Georges M (1998). A QTL with major effect on milk yield and composition maps to bovine chromosome 14. Mamm. Genome 9: 540-544.
  • Gautier M, Capitan A, Fritz S, Eggen A, Boichard D & Druet T (2007). Characterization of the DGAT1 K232A and variable number of tandem repeat polymorphisms in French dairy cattle. J Dairy Sci. 90: 2980–2988.
  • Grisart B, Coppieters W, Farnir F, Karim L, Ford C, Berzi P, Cambisano N, Mni M, Reid S, Simon P, Spelman R, Georges M & Snell R (2002). Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res. 12: 222-231.
  • Grisart B, Farnir F, Karim L, Cambisano N, Kim J J, Alex K, Mni M, Simon P, Frère J-M, Coppieters & Georges M (2004). Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proc. Natl. Acad. Sci. USA 101: 2398-2403.
  • Kaupe B, Winter A, Fries R, Erhardt G (2004). DGAT1 polymorphism in Bos indicus and Bos Taurus cattle breeds. J. Dairy Res. 71: 182–187Özdil, F & İlhan F (2012) DGAT1-exon 8 polymorphism in Anatolian buffalo. Livestock Science 149: 83-87.
  • Salimei E, Fantuz F, Coppola R, Chiofalo B, Polidori P & Varisco G (2004). Composition and characteristics of ass’s milk. Animal Research 53: 67-78.
  • Sambrook J, Fritsch E F, Maniatis T (1989). Molecular cloning: A laboratory Manual, vol. 3, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Schennink A, Stoop W M, Visker M H P W, Heck J M L, Bovenhuis H, van der Poel J J, van Valenberg H J F & van Arendonk J A M (2007). DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Animal Genetics 38: 467-473.
  • Smith S J, Cases S, Jensen D R, Chen H C, Sande E, Tow B, Sanan D A, Raber J, Eckel R H & Farese R V.Jr (2000). Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25: 87-90.
  • Spelman R J, Ford C A, McElhinney P, Gregory G C & Snell R G (2002). Characterization of the DGAT1 gene in the New Zealand dairy population. J. Dairy Sci. 85: 3514–3517.
  • Weller J I, Golik M, Seroussi E, Ezra E & Ron M (2003). Population-wide analysis of a QTL affecting milk-fat production in the Israeli Holstein population. J. Dairy Sci. 86: 2219–2227.
  • Thaller G, Krämer W, Winter A, Kaupe B, Erhardt G & Fries R (2003). Effects of DGAT1 variants on milk production traits in German cattle breeds J. Anim. Sci. 81:1911-1918.
  • Winter A, Kramer W, Werner F A O, Kollers S, Kata S, Durstewitz G, Buitkamp J, Womack J E, Thaller G & Fries R (2002). Association of a lysine-232⁄ alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Proc. Natl. Acad. Sci. USA 99: 9300-9305.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Fulya Özdil 0000-0002-5298-6997

Yayımlanma Tarihi 5 Mart 2020
Gönderilme Tarihi 5 Ağustos 2018
Kabul Tarihi 20 Kasım 2018
Yayımlandığı Sayı Yıl 2020 Cilt: 26 Sayı: 1

Kaynak Göster

APA Özdil, F. (2020). The Genetic Characterization of DGAT1 Gene in Donkey Populations Reared in Thrace Region of Turkey. Journal of Agricultural Sciences, 26(1), 8-11. https://doi.org/10.15832/ankutbd.451099

Journal of Agricultural Sciences is published open access journal. All articles are published under the terms of the Creative Commons Attribution License (CC BY).