Genetic Variability of Indels in the Prolactin and Dopamine Receptor D2 Genes and Their Association with the Yield of Allanto-Amniotic Fluid in Russian White Laying Hens

Year 2020, Volume: 26 Issue: 3, 373 - 379, 04.09.2020

Michael Romanov , Natalia V. Dementıeva Elena S. Fedorova Anna A. Krutıkova Olga V. Mıtrofanova Olga İ. Stanıshevskaya Nikolai V. Pleshanov Mikhail G. Smaragdov Andrei A. Kudınov Valeriy P. Terletsky

https://doi.org/10.15832/ankutbd.483561

Cited By: 5

Abstract

Currently, there is virtually no information on genetic factors affecting the yield of allanto-amniotic fluid, which is the raw material for the production of human and animal vaccines. Association studies including this trait are beneficial for increasing productivity of a biotechnological line of chickens used for the production of ‘Clean Eggs’. We examined here a population of the Russian White breed for the effects of indels in the prolactin (PRL) and dopamine receptor D2 (DRD2) genes on the yield of extraembryonic fluid (YEF) and embryo weight at 12.5 days of development. A 24-bp insertion in the 5' flanking region of the PRL gene significantly (P<0.01) increases YEF in the embryos. The heterozygous embryos contained the highest YEF (9.6 mL) than that of the homozygous insertion (9.4 mL) and deletion embryos (8.4 mL). We also found a significant association (P<0.001) between the PRL genotypes and egg weight (EW). The results of the present study suggest a significant association between the PRL gene variation and quantitative traits in the Russian White chickens, contributing to a long-term programme on the effective use of the genetic potential of Russian gene pool breeds and populations of chickens.

Keywords

Chicken population, Biotechnological line, Candidate genes, Insertion-deletion polymorphism, Economically important traits

References

• Al Kahtane A, Chaiseha Y & El Halawani M (2003). Dopaminergic regulation of avian prolactin gene transcription. Journal of Molecular Endocrinology 31(1): 185–196
• Bagheri Sarvestani A S, Niazi A, Zamiri M J & Dadpasand Taromsari M (2013). Polymorphisms of prolactin gene in a native chicken population and its association with egg production. Iranian Journal of Veterinary Research 14(2): 113–119
• Cui J-X, Du H L, Liang Y, Deng X-M, Li N & Zhang X-Q (2006). Association of polymorphisms in the promoter region of chicken prolactin with egg production. Poultry Science 85(1): 26–31
• Dunn I C, Miao Y W, Morris A, Romanov M N, Wilson P W & Waddington D (2004). A study of association between genetic markers in candidate genes and reproductive traits in one generation of a commercial broiler breeder hen population. Heredity 92(2): 128–134
• Fleenor D, Arumugam R & Freemark M (2006). Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling and regulation of insulin-like growth factor I. Hormone Research 66(3): 101–110
• Fulton J E (2008). Molecular genetics in a modern poultry breeding organization. World's Poultry Science Journal 64(2): 171–176
• Guo X, Fang Q, Ma C, Zhou B, Wan Y & Jiang R (2016). Whole-genome resequencing of Xishuangbanna fighting chicken to identify signatures of selection. Genetics Selection Evolution 48(1): 62
• Hall T R & Chadwick A (1984). Dopaminergic inhibition of prolactin release from pituitary glands of the domestic fowl incubated in vitro. Journal of Endocrinology 103(1): 63–69
• Hutt F B (1951). Snow-white down in the chick. Journal of Heredity 42(3): 117–120
• Jiang R S, Zhang L L, Geng Z Y, Yang T & Zhang S S (2009). Single nucleotide polymorphisms in the 5’-flanking region of the prolactin gene and the association with reproduction traits in geese. South African Journal of Animal Science 39(1): 83–87
• Kulibaba R A & Podstreshnyi A P (2012) Prolactin and growth hormone gene polymorphisms in chicken lines of Ukrainian selection. Cytology and Genetics 46(6): 390–395
• Lapa M A, Stanishevskaya O I, Dmitriev V B, Zeng T, Tian Y & Lu L (2015). The quality characteristics of eggs: Impact of the volume of allantoic-amniotic fluid of chicken embryos. Animal Husbandry and Feed Science 7(3): 140–143
• Li H-F, Zhu W-Q, Chen K-W, Wu X, Tang Q-P & Gao Y-S (2008). Associations between GHR and IGF-1 gene polymorphisms, and reproductive traits in Wenchang chickens. Turkish Journal of Veterinary and Animal Sciences 32(4): 281–285
• Paronyan I A & Yurchenko O P (1989). Domestic fowl. In: USSR N G Dmitriev & L K Ernst (Eds), Animal Genetic Resources of the, Food and Agriculture Organization of the United Nations, Rome, FAO Animal Production and Health Paper 65, Ch. 13, pp. 437–468
• Rahman M M (2014). Relationship between DNA markers and production traits in Japanese Silky fowl. Dissertation, Kagoshima University Repository, Kagoshima, Japan. Available at http://hdl.handle.net/10232/21498 (Accessed on October 18, 2018)
• Reddy I J, David C G, Sarma P V & Singh K (2002). The possible role of prolactin in laying performance and steroid hormone secretion in domestic hen. General and Comparative Endocrinology 127(3): 249–255
• Reddy I J, Ravi Kiran G, Mondal S K & Anandan S (2007). Prolactin, luteinizing hormone and steroid hormone concentration in Punjab Brown (PB3) birds immunized against vasoactive intestinal peptide during the early stages of egg production. International Journal of Poultry Science 6(9): 637–641
• Romanov M N (2001). Genetics of broodiness in poultry – a review. Asian-Australasian Journal of Animal Sciences 14(11): 1647–1654
• Rowshan J, Matsuda T, Matsuda R, Sunagawa C, Rahman M M, Kohara E, Anann K & Wada Y (2012). Relationship between the production traits and the candidate genes on chromosome 2 in the 5th generation of selection program of silky fowl. Nihon Danchi Chikusan Gakkaihou 55(2): 115–120
• VALO BioMedia GmbH. Home / News. Available at http://www.valobiomedia.com/ (Accessed on October 18, 2018)
• Wada Y, Nakamuta Y, Jiang Y, Matsuda R, Abe S & Anan K (2008). Relationship between 24-bp insertion of prolactin promoter region and performance traits in the selected population of Silkie chicken. Japanese Journal of Poultry Science 45(2): 82–86
• Wang C, Liang Z, Yu W, Feng Y, Peng X, Gong Y & Li S (2011). Polymorphism of the prolactin gene and its association with egg production traits in native Chinese ducks. South African Journal of Animal Science 41(1): 64–69
• Wang J, Hou S S, Huang W, Yang X G, Zhu X Y & Liu X L (2009). Molecular cloning of prolactin receptor of the Peking duck. Poultry Science 88(5): 1016–1022
• Youngren O M, Pitts G R, Phillips R E & Halawani M E (1995). The stimulatory and inhibitory effects of dopamine on prolactin secretion in the turkey. General and Comparative Endocrinology 98(1): 111–117
• Zhou B, Chen S Y, Zhu Q, Yao Y-G & Liu Y-P (2010). Matrilineal components and genetic relationship of Silkies from China and Japan. The Journal of Poultry Science 47(1): 22–27