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Bakla Vicia faba L. Genotiplerinin L-Dopa L-3, 4-dihydroxyphenylalanine İçeriklerinin Tespiti

Year 2016, Volume: 22 Issue: 2, 145 - 151, 01.03.2016
https://doi.org/10.1501/Tarimbil_0000001376

Abstract

Bakla bitkisi baklagil bitkilerinin toprak ıslahı ve besleyicilik açısından tüm özelliklerini taşıyan ayrıca yaşlı toplumlarda sıkça görülen Parkinson hastalığının tedavisinde kullanılabilen L-dopa içeren nadir bitkilerdendir. Bu çalışma, Samsun linde bakla genotiplerinin yaprak, çiçek ve taze meyvelerindein L-dopa içeriklerini belirlemek için yürütülmüştür. Çalışmada, 4 çeşit ve 18 hat 3 tekrarlamalı olarak tesadüf blokları deneme desenine göre Kasım ayında ekilmiştir. Denemede bitkinin vejetatif dönemde yaprakları, generatif dönemlerde çiçek ve taze meyvelerinden örnekler alınarak Yüksek Basınçlı Sıvı Kromotografi sistemi HPLC ile L-dopa içerikleri belirlenmiştir. Yapılan varyans analizi sonucu L-dopa içerikleri bakımından genotipler arasında çiçek ve meyvede P

References

  • Bozoğlu H (2005). Baklada (Vicia faba L.) Çiçeklenme ve Meyve Bağlama Durumlarının Tespiti ve Tane Verimi iİle İlişkileri. Türkiye VI. Tarla Bitkileri Kongresi 5-9 Eylül Antalya, Cilt II, s. 637-642
  • Cenarruzabeitia M N, Soria A & Larralde J (1978). The content of L-DOPA And its precursor L-tyrosine in Vicia faba grown in the north of Navarre. Anales de Edafologiay Agrobiologia 37: 677-681
  • Chowdhury S, Meunier C C, Cappelletti L & Sherer T B (2014). Improving patient participation in Parkinson‘s clinical trials: The experience of the Michael J Fox Foundation Clinical Investigation 4: 185-192
  • Daxenbichler M E, VanEtten C H, Hallinan E A, Earle F R & Barclay A S (1971). Seeds as Sources of L-Dopa. Journal of Medicinal Chemisrty 14: 463-485
  • Dorsey E R, Constantinescu R, Thompson J P, Biglan K M, Holloway R G, Kieburtz K, Marshall F J, Ravina B M, Schifitto G, Siderowf A & Tanner C M (2007). Projected number of people with Parkinson disease in the most populous nations. Neurology 68: 384-386
  • Fox M (2013). Dopamine, Acetylcholine and Parkinson’s Disease. http://www.livestrong.com/article/442896- dopamine-acetylcholine-and-parkinsons-disease. Accessed April, 4, 2013
  • Holden K (2006). Fava Beans, Levodopa, and Parkinson’s Disease; http://www.scienzavegetariana.it/nutrizione/ favabeans.html. (Accessed January, 25, 2014)
  • Huang S Y & Chen S Y (1998). Efficient l-DOPA production by Stizolobium hassjoo cell culture in a two stage configuration. Journal of Biotechnology 62: 95-103
  • Ingle P K (2003). L-Dopa bearing plants. Natural Product Radiance 2(3): 126-133
  • Kohlmunzer S, Diak Nad J & Danek H (1975). Search for sources and the possibilities of isolation of L-DOPA from local plant raw materials. Herba Polonica 21: 366-370
  • Longo R, Castellani A, Sberze P & Tibolla M (1974). Distribution of L-DOPA and related amino acids in Vicia. Phytochemistry 13(1): 167-171
  • Lucas-Carrasco R, Den Oudsten B L, Eser E & Power M J (2014). Using the satisfaction with life scale in people with parkinson’s disease: A validation study in different European countries. The Scientific World Journal doi.org/10.1155/2014/680659
  • Mohseni Mehran S M & Golshani B S (2013). Simultaneous determination of levodopa and carbidopa from fava bean, green peas and green beans by high performance liquid gas chromatography. Journal of Clinical and Diagnostic Research 7(6): 1004-1007
  • Musacchio J M (2013). Chapter 1: Enzymes involved in the biosynthesis and degradation of catecholamines. In Iverson L. Biochemistry of Biogenic Amines. Springer. pp.1-35.ISBN 1-4684-3171-4
  • PHD (2016). Dünya Parkinson Günü. Parkinson Hastalığı Derneği. http://www.parkinsondernegi. o r g . t r / m e n u / 5 5 / d u n y a - p a r k i n s o n - g u n u (Accessed February, 29, 2016)
  • Sepetoğlu H (1994). Yemeklik Dane Baklagiler. Ege Üniversitesi Ziraat Fakültesi Yayınları. Ders Notları No: 24, İzmir
  • Shetty P, Atallah M T & Shetty K (2003). Stimulation of total phenolics, l-dopa and antioxidant activity through proline-linked pentose phosphate pathway in response to proline and its analogue in germinating fava beans (Vicia faba). Process Biochemistry 38(12): 1707-1717
  • Shivananda T N, Haris G U, Rao V & Khanam S (2003). National Academy Science Letters 26: 36-43
  • Şehirali S (1988). Yemeklik Tane Baklagiller. A.Ü Ziraat Fakültesi Yayınları: 1089, Ders Kitabı: 314, Ankara
  • Vered Y, Grosskopf I, Palevitch D, Harsat A, Charach G, Weintraub M S & Graff E (1997). The influence of Vicia faba (broad bean) seedlings on urinary sodium excretion. Planta Medica 63(3): 237-240
  • WHO (2006). 3,8 Parkinson’s disease. Neurolojical Disorders; Public health challenges. pp. 140-148. http://www.who.int/mental_health/neurology/ neurological_disorders_report_web.pdf (Accessed January, 25, 2014)

Determination of L-Dopa L-3, 4-dihydroxyphenylalanine Content of Some Faba Bean Vicia faba L. Genotypes

Year 2016, Volume: 22 Issue: 2, 145 - 151, 01.03.2016
https://doi.org/10.1501/Tarimbil_0000001376

Abstract

Faba bean, reflecting all properties of legume crops such as soil improvement and benefit of human health, also contains L-dopa which can be used to cure Parkinson’s disease, is a rare plant. The study was conducted in Samsun province to determine the L-dopa content of leaf, flower and pod of faba bean genotypes. Four cultivars and 18 lines were sown on November in randomized complete blocks design with 3 replications. Samples were taken from leaves at vegatative period, flowers and fresh pods at generative period of faba bean. The L-dopa content was determined by HPLC. According to the result of variance analysis, the differences among genotypes for L-dopa content of flowers and fresh pods were found significant P

References

  • Bozoğlu H (2005). Baklada (Vicia faba L.) Çiçeklenme ve Meyve Bağlama Durumlarının Tespiti ve Tane Verimi iİle İlişkileri. Türkiye VI. Tarla Bitkileri Kongresi 5-9 Eylül Antalya, Cilt II, s. 637-642
  • Cenarruzabeitia M N, Soria A & Larralde J (1978). The content of L-DOPA And its precursor L-tyrosine in Vicia faba grown in the north of Navarre. Anales de Edafologiay Agrobiologia 37: 677-681
  • Chowdhury S, Meunier C C, Cappelletti L & Sherer T B (2014). Improving patient participation in Parkinson‘s clinical trials: The experience of the Michael J Fox Foundation Clinical Investigation 4: 185-192
  • Daxenbichler M E, VanEtten C H, Hallinan E A, Earle F R & Barclay A S (1971). Seeds as Sources of L-Dopa. Journal of Medicinal Chemisrty 14: 463-485
  • Dorsey E R, Constantinescu R, Thompson J P, Biglan K M, Holloway R G, Kieburtz K, Marshall F J, Ravina B M, Schifitto G, Siderowf A & Tanner C M (2007). Projected number of people with Parkinson disease in the most populous nations. Neurology 68: 384-386
  • Fox M (2013). Dopamine, Acetylcholine and Parkinson’s Disease. http://www.livestrong.com/article/442896- dopamine-acetylcholine-and-parkinsons-disease. Accessed April, 4, 2013
  • Holden K (2006). Fava Beans, Levodopa, and Parkinson’s Disease; http://www.scienzavegetariana.it/nutrizione/ favabeans.html. (Accessed January, 25, 2014)
  • Huang S Y & Chen S Y (1998). Efficient l-DOPA production by Stizolobium hassjoo cell culture in a two stage configuration. Journal of Biotechnology 62: 95-103
  • Ingle P K (2003). L-Dopa bearing plants. Natural Product Radiance 2(3): 126-133
  • Kohlmunzer S, Diak Nad J & Danek H (1975). Search for sources and the possibilities of isolation of L-DOPA from local plant raw materials. Herba Polonica 21: 366-370
  • Longo R, Castellani A, Sberze P & Tibolla M (1974). Distribution of L-DOPA and related amino acids in Vicia. Phytochemistry 13(1): 167-171
  • Lucas-Carrasco R, Den Oudsten B L, Eser E & Power M J (2014). Using the satisfaction with life scale in people with parkinson’s disease: A validation study in different European countries. The Scientific World Journal doi.org/10.1155/2014/680659
  • Mohseni Mehran S M & Golshani B S (2013). Simultaneous determination of levodopa and carbidopa from fava bean, green peas and green beans by high performance liquid gas chromatography. Journal of Clinical and Diagnostic Research 7(6): 1004-1007
  • Musacchio J M (2013). Chapter 1: Enzymes involved in the biosynthesis and degradation of catecholamines. In Iverson L. Biochemistry of Biogenic Amines. Springer. pp.1-35.ISBN 1-4684-3171-4
  • PHD (2016). Dünya Parkinson Günü. Parkinson Hastalığı Derneği. http://www.parkinsondernegi. o r g . t r / m e n u / 5 5 / d u n y a - p a r k i n s o n - g u n u (Accessed February, 29, 2016)
  • Sepetoğlu H (1994). Yemeklik Dane Baklagiler. Ege Üniversitesi Ziraat Fakültesi Yayınları. Ders Notları No: 24, İzmir
  • Shetty P, Atallah M T & Shetty K (2003). Stimulation of total phenolics, l-dopa and antioxidant activity through proline-linked pentose phosphate pathway in response to proline and its analogue in germinating fava beans (Vicia faba). Process Biochemistry 38(12): 1707-1717
  • Shivananda T N, Haris G U, Rao V & Khanam S (2003). National Academy Science Letters 26: 36-43
  • Şehirali S (1988). Yemeklik Tane Baklagiller. A.Ü Ziraat Fakültesi Yayınları: 1089, Ders Kitabı: 314, Ankara
  • Vered Y, Grosskopf I, Palevitch D, Harsat A, Charach G, Weintraub M S & Graff E (1997). The influence of Vicia faba (broad bean) seedlings on urinary sodium excretion. Planta Medica 63(3): 237-240
  • WHO (2006). 3,8 Parkinson’s disease. Neurolojical Disorders; Public health challenges. pp. 140-148. http://www.who.int/mental_health/neurology/ neurological_disorders_report_web.pdf (Accessed January, 25, 2014)
There are 21 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Nurdoğan Topal This is me

Hatice Bozoğlu This is me

Publication Date March 1, 2016
Submission Date January 1, 2016
Published in Issue Year 2016 Volume: 22 Issue: 2

Cite

APA Topal, N., & Bozoğlu, H. (2016). Determination of L-Dopa L-3, 4-dihydroxyphenylalanine Content of Some Faba Bean Vicia faba L. Genotypes. Journal of Agricultural Sciences, 22(2), 145-151. https://doi.org/10.1501/Tarimbil_0000001376

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