Wnt sinyal yolağı ve kanser

Cilt: 15 Sayı: 2 24 Haziran 2016
Buket Altınok , Asuman Sunguroğlu
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WNT Sinyal Yolağı ve Kanser

Abstract

Wnt signaling pathway is critically important in stem cell biology, both in homeostatic maintenance and regeneration of tissues and organs. Aberrant activation of this pathway has been described as a key player in the development of a wide array of tumor types, via affecting the behavior of Cancer Stem Cells (CSCs). CSCs are believed to be responsible for disease relapse, as they possess drug-resistance properties.The development of new therapeutic drugs targeting this pathway topromise new hope to eliminate CSCs and achieve cancer eradication. We review the Wnt signaling pathway, the relationship between this pathway and CSC term and recent therapeutic approaches to target this pathway and their clinical applications

Keywords

Wnt signaling pathway, cancer stem cell, therapeutic drugs

Kaynakça

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Kaynak Göster

APA
Altınok, B., & Sunguroğlu, A. (2016). Wnt sinyal yolağı ve kanser. Ankara Sağlık Hizmetleri Dergisi, 15(2), 27-38. https://doi.org/10.1501/Ashd_0000000118
AMA
1.Altınok B, Sunguroğlu A. Wnt sinyal yolağı ve kanser. ASHD. 2016;15(2):27-38. doi:10.1501/Ashd_0000000118
Chicago
Altınok, Buket, ve Asuman Sunguroğlu. 2016. “Wnt sinyal yolağı ve kanser”. Ankara Sağlık Hizmetleri Dergisi 15 (2): 27-38. https://doi.org/10.1501/Ashd_0000000118.
EndNote
Altınok B, Sunguroğlu A (01 Haziran 2016) Wnt sinyal yolağı ve kanser. Ankara Sağlık Hizmetleri Dergisi 15 2 27–38.
IEEE
[1]B. Altınok ve A. Sunguroğlu, “Wnt sinyal yolağı ve kanser”, ASHD, c. 15, sy 2, ss. 27–38, Haz. 2016, doi: 10.1501/Ashd_0000000118.
ISNAD
Altınok, Buket - Sunguroğlu, Asuman. “Wnt sinyal yolağı ve kanser”. Ankara Sağlık Hizmetleri Dergisi 15/2 (01 Haziran 2016): 27-38. https://doi.org/10.1501/Ashd_0000000118.
JAMA
1.Altınok B, Sunguroğlu A. Wnt sinyal yolağı ve kanser. ASHD. 2016;15:27–38.
MLA
Altınok, Buket, ve Asuman Sunguroğlu. “Wnt sinyal yolağı ve kanser”. Ankara Sağlık Hizmetleri Dergisi, c. 15, sy 2, Haziran 2016, ss. 27-38, doi:10.1501/Ashd_0000000118.
Vancouver
1.Buket Altınok, Asuman Sunguroğlu. Wnt sinyal yolağı ve kanser. ASHD. 01 Haziran 2016;15(2):27-38. doi:10.1501/Ashd_0000000118