BibTex RIS Kaynak Göster

Yıl 2016, Cilt: 15 Sayı: 1, 19 - 23, 27.05.2016

Tülin Özkan Buket Altınok Aynur Karadağ Zeynep Karabay Arzu Yalda Hekmatshoar Nilgün Sayınalp Asuman Sunguroğlu

https://doi.org/10.1501/Ashd_0000000112

Öz

Acute myeloid leukemia is a type of clonal hematopoietic stem cell disorder displaying different genetic abnormalities. The critical balance between the self-renewal and differentiation of leukemia stem cells are regulated by various genes and signaling pathways that are regulated by these genes. Wnt/ β-catenin signaling pathway controls the self-renewal of hematopoietic stem cells by the regulation of β-catenin. Akirin-2 is an evolutionarily conserved nuclear protein which is thought to play important roles in immunity, NFκB and Wnt/β-catenin signaling pathways. In this study, expression of Akirin-2 gene was investigated in the CD34+ hematopoietic stem cells of patients with high β-catenin gene expression. Our results showed that the expression level of Akirin-2 gene was significantly higher in CD34+ hematopoietic stem cells of patients compared to healthy subjects and Akirin-2 gene could have an important role in AML pathogenesis

Anahtar Kelimeler

AML Akirin2 β-catenin

Kaynakça

  • Beutler B, Moresco EM. 2008. Akirins versus infection. Nat Immunol, 9:7-9.
  • Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffman JA, Akira S, Boutros M, Reichhart JM. 2008. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol, 9: 97-104.
  • Holliday, R. 2006. Epigenetics: a historical overview.Epigenetics, 1: 76–80.
  • Ilyas, M. 2005. Wnt signalling and the mechanistic basis of tumour development. J Pathol, 205: (2):130–144.
  • Jemal, A., Siegel, R., Xu, J., Ward, E. 2010. Cancer statistics. CA Cancer J Clin, 2010;60:277–300.
  • Murdoch, B., Chadwick, K., Martin, M, et al. 2003. Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci USA, 100:3422–3427.
  • Passegué, E., Jamieson, CH., Ailles, LE., Weissman, IL. 2003. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A. 30;100 Suppl, 1:11842-9.
  • Perez-Moreno, M., Jamora, C., Fuchs, E. 2003. Sticky business: orchestrating cellular signals at adherens junctions. Cell, 112, 535-548.
  • Reya, T., Duncan , AW., Ailles, L., Domen, J., Scherer, DC., Willert, K., Hintz, L., Nusse, R., Weissman, IL. 2003. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 423:409-414.
  • Scheller M, Schonheit J, Zimmermenn K, Leser U, Rosenbauer F, Leutz A. 2013. Cross talk between Wnt/β- catenin and Irf8 in leukemia progression and drug resistance. The Journal of Experimental Medicine, 210: 2239-2256.
  • Stone, R.M., O’donnell, M.R., Sekeres, M.A. Acute Myeloid Leukemia. 2004. Hematology Am Soc Hematol Educ Program. 98-117.
  • Tan, X. 2008. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology, 47:1667–1679.
  • Wodarz, A., Nusse, R. 1998. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol, 14:59–88.
  • Woodward, W.A., Chen, M.S., Behbod, F., Rosen, J.M. On mammary stem cells. 2005. J Cell Sci, 118 (Pt 16):3585-94.

Akut miyeloid lösemide akirin2 geninin ifadesi

Yıl 2016, Cilt: 15 Sayı: 1, 19 - 23, 27.05.2016

Tülin Özkan Buket Altınok Aynur Karadağ Zeynep Karabay Arzu Yalda Hekmatshoar Nilgün Sayınalp Asuman Sunguroğlu

https://doi.org/10.1501/Ashd_0000000112

Öz

Akut miyeloid lösemi (AML), farklı genetik anomaliler gösteren bir grup klonal hematopoetik kök hücre bozukluğudur. Lösemik kök hücrelerin kendini yenileme ve farklılaşmaları arasındaki hassas dengeyi, çeşitli genler ve bu genlerin düzenlediği sinyal yolakları kontrol etmektedir. Wnt/β-katenin sinyal yolağı, β-kateninin regülasyonu aracılığıyla hematopoetik kök hücrelerin kendilerini yenilemelerini kontrol etmektedir. Akirin2 proteini ise, immünite, NFκB ve Wnt/β-katenin sinyal yolaklarında çok önemli rolleri olduğu düşünülen yüksek derecede korunmuşluk gösteren bir proteindir. Bu çalışmada β-katenin gen ekspresyonu yüksek olan AML hastalarının CD34+ hematopoetik kök hücrelerinde Akirin2 geninin ifadesi araştırılmıştır. Sonuç olarak Akirin2 gen ifadesinin AML hastalarının CD34+ hematopoetik kök hücrelerinde sağlıklı bireylere göre anlamlı derecede artmış olduğu tespit edilmiş ve Akirin2 geninin AML patogenezinde önemli rollerinin olabileceğine dair ilk veriler elde edilmiştir

Anahtar Kelimeler

AML Akirin2 β-katenin

Kaynakça

  • Beutler B, Moresco EM. 2008. Akirins versus infection. Nat Immunol, 9:7-9.
  • Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffman JA, Akira S, Boutros M, Reichhart JM. 2008. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol, 9: 97-104.
  • Holliday, R. 2006. Epigenetics: a historical overview.Epigenetics, 1: 76–80.
  • Ilyas, M. 2005. Wnt signalling and the mechanistic basis of tumour development. J Pathol, 205: (2):130–144.
  • Jemal, A., Siegel, R., Xu, J., Ward, E. 2010. Cancer statistics. CA Cancer J Clin, 2010;60:277–300.
  • Murdoch, B., Chadwick, K., Martin, M, et al. 2003. Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci USA, 100:3422–3427.
  • Passegué, E., Jamieson, CH., Ailles, LE., Weissman, IL. 2003. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A. 30;100 Suppl, 1:11842-9.
  • Perez-Moreno, M., Jamora, C., Fuchs, E. 2003. Sticky business: orchestrating cellular signals at adherens junctions. Cell, 112, 535-548.
  • Reya, T., Duncan , AW., Ailles, L., Domen, J., Scherer, DC., Willert, K., Hintz, L., Nusse, R., Weissman, IL. 2003. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 423:409-414.
  • Scheller M, Schonheit J, Zimmermenn K, Leser U, Rosenbauer F, Leutz A. 2013. Cross talk between Wnt/β- catenin and Irf8 in leukemia progression and drug resistance. The Journal of Experimental Medicine, 210: 2239-2256.
  • Stone, R.M., O’donnell, M.R., Sekeres, M.A. Acute Myeloid Leukemia. 2004. Hematology Am Soc Hematol Educ Program. 98-117.
  • Tan, X. 2008. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology, 47:1667–1679.
  • Wodarz, A., Nusse, R. 1998. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol, 14:59–88.
  • Woodward, W.A., Chen, M.S., Behbod, F., Rosen, J.M. On mammary stem cells. 2005. J Cell Sci, 118 (Pt 16):3585-94.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA84SC44HC
Bölüm Araştırma Makalesi
Yazarlar

Tülin Özkan Bu kişi benim

Buket Altınok Bu kişi benim

Aynur Karadağ Bu kişi benim

Zeynep Karabay Arzu Bu kişi benim

Yalda Hekmatshoar Bu kişi benim

Nilgün Sayınalp Bu kişi benim

Asuman Sunguroğlu Bu kişi benim

Yayımlanma Tarihi 27 Mayıs 2016
Gönderilme Tarihi 1 Mayıs 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 15 Sayı: 1

Kaynak Göster

APA Özkan, T., Altınok, B., Karadağ, A., Karabay Arzu, Z., vd. (2016). Akut miyeloid lösemide akirin2 geninin ifadesi. Ankara Sağlık Hizmetleri Dergisi, 15(1), 19-23. https://doi.org/10.1501/Ashd_0000000112
AMA Özkan T, Altınok B, Karadağ A, Karabay Arzu Z, Hekmatshoar Y, Sayınalp N, Sunguroğlu A. Akut miyeloid lösemide akirin2 geninin ifadesi. ASHD. Mayıs 2016;15(1):19-23. doi:10.1501/Ashd_0000000112
Chicago Özkan, Tülin, Buket Altınok, Aynur Karadağ, Zeynep Karabay Arzu, Yalda Hekmatshoar, Nilgün Sayınalp, ve Asuman Sunguroğlu. “Akut Miyeloid lösemide Akirin2 Geninin Ifadesi”. Ankara Sağlık Hizmetleri Dergisi 15, sy. 1 (Mayıs 2016): 19-23. https://doi.org/10.1501/Ashd_0000000112.
EndNote Özkan T, Altınok B, Karadağ A, Karabay Arzu Z, Hekmatshoar Y, Sayınalp N, Sunguroğlu A (01 Mayıs 2016) Akut miyeloid lösemide akirin2 geninin ifadesi. Ankara Sağlık Hizmetleri Dergisi 15 1 19–23.
IEEE T. Özkan, B. Altınok, A. Karadağ, Z. Karabay Arzu, Y. Hekmatshoar, N. Sayınalp, ve A. Sunguroğlu, “Akut miyeloid lösemide akirin2 geninin ifadesi”, ASHD, c. 15, sy. 1, ss. 19–23, 2016, doi: 10.1501/Ashd_0000000112.
ISNAD Özkan, Tülin vd. “Akut Miyeloid lösemide Akirin2 Geninin Ifadesi”. Ankara Sağlık Hizmetleri Dergisi 15/1 (Mayıs 2016), 19-23. https://doi.org/10.1501/Ashd_0000000112.
JAMA Özkan T, Altınok B, Karadağ A, Karabay Arzu Z, Hekmatshoar Y, Sayınalp N, Sunguroğlu A. Akut miyeloid lösemide akirin2 geninin ifadesi. ASHD. 2016;15:19–23.
MLA Özkan, Tülin vd. “Akut Miyeloid lösemide Akirin2 Geninin Ifadesi”. Ankara Sağlık Hizmetleri Dergisi, c. 15, sy. 1, 2016, ss. 19-23, doi:10.1501/Ashd_0000000112.
Vancouver Özkan T, Altınok B, Karadağ A, Karabay Arzu Z, Hekmatshoar Y, Sayınalp N, Sunguroğlu A. Akut miyeloid lösemide akirin2 geninin ifadesi. ASHD. 2016;15(1):19-23.