IN VITRO BIOLOGICAL ACTIVITY STUDIES ON TANACETUM ABROTANIFOLIUM (L.) DRUCE (ASTERACEAE)

Yıl 2017, Cilt: 18 Sayı: 2, 439 - 455, 30.06.2017

İbrahim Geçibesler

https://doi.org/10.18038/aubtda.284496

Cited By: 2

Öz

Tanacetum
L. (Asteraceae) species have been used by local
people in folk medicine for centuries in Turkey to treat antipyretic, headache,
tinnitus, dizziness and against difficulties in childbirth. We performed
detailed biological activity screening tests of Tanacetum abrotanifolium, collected from its natural habitats in
the eastern region of Turkey, for the first time. To obtain active compound
from aerial parts of T. abrotanifolium
by using chromatographic techniques, anticancer, antimicrobial and antioxidant
assays were applied. Total phenol, flavonoid, β-carotene and lycopene contents were determined quantitatively.
The isolation procedure was carried out successfully through thin layer and
column chromatographies. Bioactivity-guided fractionation led to the isolation
of luteolin-7-O-glucoside, an agent
of anticancer, antimicrobial and antioxidant. This active compound was isolated
from aerial parts of T. abrotanifolium
for the first time.

Anahtar Kelimeler

Tanacetum abrotanifolium, luteolin-7-O-glucoside, anticancer activity, antimicrobial potency

Kaynakça

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