Neuroprotective Effect of Paeonol in the Rat Model of Traumatic Brain Injury
Abstract
Objectives: Traumatic brain injury (TBI) is a major cause of disability and mortality that induces oxidative stress and apoptosis causing cellular damage. Several animal models have shown paeonol to be a powerful antioxidant, antiapoptotic, and neuroprotective substance. This study aimed to investigate possible neuroprotective effects of paeonol in a rat TBI model.
Materials and Methods: Thirty-two male rats were divided into four groups: control, trauma, vehicle, and paeonol groups. Trauma, vehicle, and paeonol groups were subjected to closed-head, contusive weight-drop injuries. The vehicle (saline) or paeonol (50 mg/kg) was orally administered as premedication for 15 days. Brain samples were obtained 24 hours after trauma. Histomorphological evaluation of the cerebral cortex was performed using electron and light microscopy.
Results: Histopathological examination revealed that the TBI-induced cerebral cortex damage was less in the paeonol group.
Conclusion: Paeonol exhibited neuroprotective and anti-edematous effects against TBI.
Keywords
Anti-edema, Neuroprotection, Paeonol, Traumatic Brain Injury
Ethical Statement
Ethics Committee Approval: Animal care and all experiments were conducted according tothe European Parliament and Council directive 2010/63/EU of September 22, 2010 with regard to the protection of animals for experimental use. Animal ethics committee permission is obtained from The Saki Yenilli Animal Care and Use Committee (0001.01.02). They reviewed and approved all experimental procedures used in this
study.
Informed Consent: Due to the fact that this study is experiment study, informed consent was not obtained.
Peer-review: Internally and externally peer-reviewed.
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