ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS
Abstract
n this study, adenosine deaminase activity was determined in sera from 24 patients with reactive arthritis. The patients were classified according to the sedimentation rafes and number of joints affected. ADA activities was found lower in the patient groups than control group. We found that the lowest values of ADA were in the patients having two joints affected (p< 0.005) and results were also meaningful in the patients having one joint affected (p< 0.01). Decreases in ADA activities however were not meaningful in the patients having three joints affected (p> 0.05) ADA activities was not meaningful in the patients with sedimantation rates between 30 and 60 mm/hr. However, we obtained meaningful results in the groups with sedimantation rates of 0-30 and >60 (p< 0:025 and p< 0.05 respectively). We found no meaningful differences between ADA activity, and sedimantation rates and number of joints affected. We suggest that decreased ADA activities might be an indicator of the immune system depression in reactive arthritis.
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References
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