Case Report
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Malign Hastalıklarda -Lipitler ve Lipoproteinlerin Immün Sisteme Etkisi

Year 1990, Volume: 43 Issue: 1, 119 - 128, 31.03.1990

Abstract

Histopatolojik olarak malignite tanısı almış 31 hasta ve 20 sağlıklı kişilerde, serumda lipid elektroforezi, kolesterol, lipid, trigliserid miktarları, E rozet testi, serum immünglobulinleri seviyeleri, lenivent yüzey immtnglobülinleri incelendi. {ki grubun. karşılaştırılmasında alfa lipoprotein (HDL), E rozet testi, slgA degerlerinin hasta grupta, kontrollerden anlamlı derecede farkli olduğu bulundu. Immiinolojik parametrelerden bazılari ile lipidler ve lipoproteinler arasında ilişki arandı. E rozet ile prebeta (VLDL) arasında negatif, VLDL ile slgA arasında pozitif bir korelasyon bulundu. Literatürde de bunu destekleyen yayımlarım olması nedeniyle VLDL’nin immiumodepressan olma ihtimalini düşündük.

Project Number

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References

  • Barclay, M, Skipski, V.P., Terebesus-Kekish, O., Greene, M. : Effect of cancer upon high-density and other lipoproteins, Cancer Res, 30 : 2420-2430, 1970.
  • 2. Bellanti, J.A. : Immunology I]. WB Saunders Company, 1978, § ; 161, 459. Ben-Bassat, I, Many, A.. Modan, M.: Serum immunglobulins in chronic lymp- _.hocytic leukemia. Am. J. Med, Sci. 278 : 4-9, 1979.
  • 4, Bowman, W.P., Melvin, S., Mauer, A.M. : Cell markers in lymphomas and leukemias, Adv, Intern. Med. 25 : 391-425, 1980.Malign Hastaltklarda - Lipidler ve Lipoproteinlerin immiin Sisteme Etkisi "127 Broitman, S.A., Vitale, J.J. : Polyunsaturated fat, cholesterol and large bowel tumorigenesis.
  • 5. Cancer, 40 : 2455-2463, 1977. - Burchard, H. : Chem. Zbl. 61 : 25, 1890. Chisari, F.V., Edgington, T.S. : Lymphocyte E rosette inhibitory factor : A regulatory serum lipoprotein. J. Exp. Med., 142 : 1092-1105 ,1975. Chisari, F.V. : : Immunoregulatory properties of human ne in very ‘low density lipoproteins. J. Immunol., 199 : 2129-2135, 1977. 6.Curtiss, L.K., De Keer, D.H., Edgington, T.S. : Influence of the immunoregulatory serum lipoprotein LDL-In on the in vivo proliferation and differantiation of antigen-binding and antibody-secreting lymphocytes during a primary immune response. Cell. Immunol., 49 : 1-11, 1980. Curtiss, L.K., Edgington, T.S. : Immunoregulatory plasma low density lipoprotein :
  • 7. The biologic activity and receptor-bindings specificity is independent of the neutral lipids. J. Immunol. 126 : 1008-1012, 1981. Durrum, E.L., Paul, M.H. and Smith, E.R.B.: Science. 116 : 428, 1952. Edgington, T.S., Curtiss, L.K. : Plasma lipoproteins with bioregulatory properties including the capacity to regulate lymphocte function and the immune response. Cancer Res., 41 : 3786-3788, 1981.
  • 8.Heiniger, H.J.: Cholesterol and its biosynthesis in normal and malignant lymphocytes. Cancer Res., 41 : 3792-3794, 1981.
  • 9.Huber, L.A. et al. : Immunoregulatory properties of human low and high density ipoproteins, immunobiology, 175 : 265-266, 1987. Liebermann, C. ; Chem. Ber, 18 : 1803, 1885. 10.Lobo, P.J., Westervett, B., Horwitz, D. : Identification of two populations of immunoglobulin-bearing lymphocytes in man. J. Immunol. 114 : 116-126, 1975. Nydegeger, U.E., Butler, R.E. : Serum lipoprotein levels in patients with cancer Cancer Res., 32 : 1656-1760, 1972.
  • 11.Opat, P., Kolar, V. : Humoral and cellular immunity in long term survivingpatients with malignant lymphoma. Neoplasma, 27 ; 301-305, 1990. Reid, M.M., Craft, A.W. : Immunoglobulin concentrations in children receiving treatment for acute lymphoblastic leukemia. J. Clin. Pathol. 34 : 479-482, 1981.
  • 12.Royer, M.E., Ko, H. : Anal. Biochem. 29 : 405, 1969. Royston, L, Dillman, R., Jaffe, E, : Cell-surface markers in lymphoproliferative disease. N. Engl. J. Med., 21 : 1802-1304, 1981, Schein, P.S. ; Oncolipids?, N. Engl. J. Med., 315 : 1410-1411, 1986. Slater, G., Papatestas, A.E. : Serum immunoglobulins in colorectal cancer. JJ. Surg. Oncol., 14: 167-171, 1980. Stites, D., Stobo, J, Wells, J.V. : Basic and Clinical Immunology, Lange Medical
  • 13.Publications, 1987, p : 27, 186, 249, 290.25. Townes, AS., Proslethwaite, AE, : Lymphocyte surface markers in human disease, Adv. Intern. Med., 22 : 97-115, 1977.
  • 14. Waddel, C., Taunton, D. ; Inmbition of lymphoproliferation by -hyperipaprote ‘inemic plasma. J. Clin. Invest, 58 : 950-954, 1976. 2
  • 15. Wesselius, LJ. et al. : Lymphocyte subsets in lung cancer. Chest, 91 ; 725-729, 1987.
  • 16. Zéllner, N. and Kirsch, K.: 2 ges. exp. Med. 135 : 545, 1962.

«The effect of lipids and lipoproteins on immune system in malignant diseases»

Year 1990, Volume: 43 Issue: 1, 119 - 128, 31.03.1990

Abstract

In this study, 31 patients with malignancies and 20 healthy persons were examined. Lipid electrophoresis, cholesterol, lipid, trigliserid, E rosette test, serum immunoglobulins and lymphocyte surface immunoglobulins were performed.In patient group, alpha lipoprotein (HDL), E rosette test and
sIgA were, significantly different from healthy individuals, The correlation, between some of the immunological parameters and lipids, lipoproteins was searched. Negative correlation between E rosette and VLDL and positive correlation between VLDL and sIlgA were found. Since, there are papers supporting this finding, we thought
the possibility of being an immunodepressan lipoprotein of VLDL.

Supporting Institution

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Project Number

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Thanks

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References

  • Barclay, M, Skipski, V.P., Terebesus-Kekish, O., Greene, M. : Effect of cancer upon high-density and other lipoproteins, Cancer Res, 30 : 2420-2430, 1970.
  • 2. Bellanti, J.A. : Immunology I]. WB Saunders Company, 1978, § ; 161, 459. Ben-Bassat, I, Many, A.. Modan, M.: Serum immunglobulins in chronic lymp- _.hocytic leukemia. Am. J. Med, Sci. 278 : 4-9, 1979.
  • 4, Bowman, W.P., Melvin, S., Mauer, A.M. : Cell markers in lymphomas and leukemias, Adv, Intern. Med. 25 : 391-425, 1980.Malign Hastaltklarda - Lipidler ve Lipoproteinlerin immiin Sisteme Etkisi "127 Broitman, S.A., Vitale, J.J. : Polyunsaturated fat, cholesterol and large bowel tumorigenesis.
  • 5. Cancer, 40 : 2455-2463, 1977. - Burchard, H. : Chem. Zbl. 61 : 25, 1890. Chisari, F.V., Edgington, T.S. : Lymphocyte E rosette inhibitory factor : A regulatory serum lipoprotein. J. Exp. Med., 142 : 1092-1105 ,1975. Chisari, F.V. : : Immunoregulatory properties of human ne in very ‘low density lipoproteins. J. Immunol., 199 : 2129-2135, 1977. 6.Curtiss, L.K., De Keer, D.H., Edgington, T.S. : Influence of the immunoregulatory serum lipoprotein LDL-In on the in vivo proliferation and differantiation of antigen-binding and antibody-secreting lymphocytes during a primary immune response. Cell. Immunol., 49 : 1-11, 1980. Curtiss, L.K., Edgington, T.S. : Immunoregulatory plasma low density lipoprotein :
  • 7. The biologic activity and receptor-bindings specificity is independent of the neutral lipids. J. Immunol. 126 : 1008-1012, 1981. Durrum, E.L., Paul, M.H. and Smith, E.R.B.: Science. 116 : 428, 1952. Edgington, T.S., Curtiss, L.K. : Plasma lipoproteins with bioregulatory properties including the capacity to regulate lymphocte function and the immune response. Cancer Res., 41 : 3786-3788, 1981.
  • 8.Heiniger, H.J.: Cholesterol and its biosynthesis in normal and malignant lymphocytes. Cancer Res., 41 : 3792-3794, 1981.
  • 9.Huber, L.A. et al. : Immunoregulatory properties of human low and high density ipoproteins, immunobiology, 175 : 265-266, 1987. Liebermann, C. ; Chem. Ber, 18 : 1803, 1885. 10.Lobo, P.J., Westervett, B., Horwitz, D. : Identification of two populations of immunoglobulin-bearing lymphocytes in man. J. Immunol. 114 : 116-126, 1975. Nydegeger, U.E., Butler, R.E. : Serum lipoprotein levels in patients with cancer Cancer Res., 32 : 1656-1760, 1972.
  • 11.Opat, P., Kolar, V. : Humoral and cellular immunity in long term survivingpatients with malignant lymphoma. Neoplasma, 27 ; 301-305, 1990. Reid, M.M., Craft, A.W. : Immunoglobulin concentrations in children receiving treatment for acute lymphoblastic leukemia. J. Clin. Pathol. 34 : 479-482, 1981.
  • 12.Royer, M.E., Ko, H. : Anal. Biochem. 29 : 405, 1969. Royston, L, Dillman, R., Jaffe, E, : Cell-surface markers in lymphoproliferative disease. N. Engl. J. Med., 21 : 1802-1304, 1981, Schein, P.S. ; Oncolipids?, N. Engl. J. Med., 315 : 1410-1411, 1986. Slater, G., Papatestas, A.E. : Serum immunoglobulins in colorectal cancer. JJ. Surg. Oncol., 14: 167-171, 1980. Stites, D., Stobo, J, Wells, J.V. : Basic and Clinical Immunology, Lange Medical
  • 13.Publications, 1987, p : 27, 186, 249, 290.25. Townes, AS., Proslethwaite, AE, : Lymphocyte surface markers in human disease, Adv. Intern. Med., 22 : 97-115, 1977.
  • 14. Waddel, C., Taunton, D. ; Inmbition of lymphoproliferation by -hyperipaprote ‘inemic plasma. J. Clin. Invest, 58 : 950-954, 1976. 2
  • 15. Wesselius, LJ. et al. : Lymphocyte subsets in lung cancer. Chest, 91 ; 725-729, 1987.
  • 16. Zéllner, N. and Kirsch, K.: 2 ges. exp. Med. 135 : 545, 1962.
There are 13 citations in total.

Details

Primary Language Turkish
Subjects Autoimmunity, ​Internal Diseases
Journal Section Case Report
Authors

Ümit Ölmez

Project Number -
Publication Date March 31, 1990
Published in Issue Year 1990 Volume: 43 Issue: 1

Cite

APA Ölmez, Ü. (1990). Malign Hastalıklarda -Lipitler ve Lipoproteinlerin Immün Sisteme Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 43(1), 119-128.
AMA Ölmez Ü. Malign Hastalıklarda -Lipitler ve Lipoproteinlerin Immün Sisteme Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. March 1990;43(1):119-128.
Chicago Ölmez, Ümit. “Malign Hastalıklarda -Lipitler Ve Lipoproteinlerin Immün Sisteme Etkisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 43, no. 1 (March 1990): 119-28.
EndNote Ölmez Ü (March 1, 1990) Malign Hastalıklarda -Lipitler ve Lipoproteinlerin Immün Sisteme Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 43 1 119–128.
IEEE Ü. Ölmez, “Malign Hastalıklarda -Lipitler ve Lipoproteinlerin Immün Sisteme Etkisi”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 43, no. 1, pp. 119–128, 1990.
ISNAD Ölmez, Ümit. “Malign Hastalıklarda -Lipitler Ve Lipoproteinlerin Immün Sisteme Etkisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 43/1 (March1990), 119-128.
JAMA Ölmez Ü. Malign Hastalıklarda -Lipitler ve Lipoproteinlerin Immün Sisteme Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1990;43:119–128.
MLA Ölmez, Ümit. “Malign Hastalıklarda -Lipitler Ve Lipoproteinlerin Immün Sisteme Etkisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 43, no. 1, 1990, pp. 119-28.
Vancouver Ölmez Ü. Malign Hastalıklarda -Lipitler ve Lipoproteinlerin Immün Sisteme Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1990;43(1):119-28.