Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats

Abstract

Çalışmanın amacı, kırmızı kantaron (Centaurium erythraea) yağı ve defne (Laurus nobilis) tohumu yağının ratlarda tam kalınlıklı eksizyonel deri yara modelinde etkilerinin araştırılmasıdır. Çalışmada kullanılan 18 adet erişkin, erkek Wistar rat; kontrol (CO), kırmızı kantarın yağı (CCO) ve defne tohumu yağı (LSO) olmak üzere üç gruba (n=6) ayırıldı. Genel anestezi altında her bir ratın sırtında interskapular bölgenin kaudalinde tam kalınlıklı eksizyonel yara (2.25 cm2) oluşturuldu. Tedaviler tüm gruplarda günde bir kez topikal olarak uygulandı. Yara alanı ölçümleri CCO’nun yara iyileşmesini hızlandırdığını, LSO’nun ise yara iyileşmesini geciktirdiğini gösterdi. Histopatolojik sonuçlarda kan damarları oluşumu, fiber sentezi, granülasyon ve mononükleer hücreler CCO grubundaki yara dokularında diğer gruplardan daha yüksek, LSO’da ise CO grubundan daha yüksek bulundu. Biyokimyasal sonuçlar gruplar arasında TP, GLU ve UREA değerlerinde anlamlı farklılıklar gösterdi (p < 0.05). Sonuç olarak, bu çalışma, ratlarda deneysel tam kalınlıklı eksizyonel deri yara modelinde kırmızı kantaron yağının topikal kullanımının yara iyileşmesini hızlandırdığını, defne tohumu yağının ise yara iyileşmesini olumsuz etkilediğini ortaya koymaktadır.

Keywords

• Alternatif
• bitkisel yağ
• deneysel
• dermatoloji
• in vivo
• kantaron

Effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil on full-thickness excisional skin wound healing in rats

Abstract

The aim of this study was to investigate the effects of common centaury (Centaurium erythraea) oil and laurel (Laurus nobilis) seed oil in a full-thickness excisional skin wound model in rats. In the present study, 18 adult male Wistar rats were divided into three groups (n=6) the control (CO) group, the common centaury oil (CCO) group, and the laurel seed oil (LSO) group. Under general anesthesia, a full-thickness excisional wound (2.25 cm²) was created on the caudal of the interscapular region on the back of the rats. Treatments were applied topically once a day in all groups. Wound area measurements revealed that the use of CCO accelerated wound healing, while the use of LSO disturbed the healing process (P≤0.001). In the histopathological results, blood vessel formation, fiber synthesis, granulation, and mononuclear cells in the wounds were higher in the CCO group than the other groups and higher in the LSO group than the CO group. Biochemical results revealed differences between groups in TP, GLU, and UREA values (P<0.05). As a result, it was determined that the topical use of common centaury oil accelerated wound healing, while laurel seed oil adversely affected wound healing in the experimental excisional full-thickness skin wound model in rats.

Keywords

• Alternative
• centaurium
• dermatology
• experimental
• herbal oil
• in vivo

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