The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo

Emsal İbiş; Metin Erdoğan

doi:10.33988/auvfd.1675808

The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo

Abstract

The Signal Transducer and Activator of Transcription 5A (STAT5A) gene plays a crucial role in the development of the mammary gland and milk production by mediating prolactin (PRL) signaling. These functions make STAT5A a promising candidate gene for further research, especially in milk-producing animals. The aim of this study was to determine the relationship between polymorphisms in the 1720 bp segment spanning exons 6-9 of the STAT5A gene and the milk yield of 192 Anatolian buffalo raised in the Afyonkarahisar region. The total of 13 polymorphisms were identified through Sanger sequencing, including five in the 7th intron, seven in the 8th intron, and only one of them in the 8th exon. The relationship between adjusted milk yields and SNPs was analyzed using ANOVA (one-way analysis of variance). The association between milk and SNP 12237 (g+12237 C>T) was located in exon 8 of the STAT5A gene. Therefore, milk yield was found to be significant (P<0.01). Buffaloes with the CC genotype were found to produce less milk than buffaloes with the CT genotype for this SNP. In conclusion, our findings suggest that SNP 12237 can be used in buffalo breeding programs to improve milk yield.

Keywords

Project Number

Afyon Kocatepe University Scientific Research Project Coordination Unit, 19.SAĞ.BİL.24.

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Details

Primary Language

English

Subjects

Animal Science, Genetics and Biostatistics

Journal Section

Research Article

Authors

Emsal İbiş ^*
0000-0001-8006-2954
Türkiye

Metin Erdoğan
0000-0003-0975-1989
Türkiye

Early Pub Date

November 5, 2025

Publication Date

January 1, 2026

Submission Date

April 24, 2025

Acceptance Date

September 18, 2025

Published in Issue

Year 2026 Volume: 73 Number: 1

DOI

https://doi.org/10.33988/auvfd.1675808

IZ

https://izlik.org/JA87PR32NN

Cite

RIS / Bibtex

APA

İbiş, E., & Erdoğan, M. (2026). The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 73(1), 7-12. https://doi.org/10.33988/auvfd.1675808

AMA

1.İbiş E, Erdoğan M. The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo. Ankara Univ Vet Fak Derg. 2026;73(1):7-12. doi:10.33988/auvfd.1675808

Chicago

İbiş, Emsal, and Metin Erdoğan. 2026. “The Effects of SNPs Between Exons 6-9 in the STAT5A Gene on Milk Yield in Anatolian Buffalo”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 73 (1): 7-12. https://doi.org/10.33988/auvfd.1675808.

EndNote

İbiş E, Erdoğan M (January 1, 2026) The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo. Ankara Üniversitesi Veteriner Fakültesi Dergisi 73 1 7–12.

IEEE

[1]E. İbiş and M. Erdoğan, “The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo”, Ankara Univ Vet Fak Derg, vol. 73, no. 1, pp. 7–12, Jan. 2026, doi: 10.33988/auvfd.1675808.

ISNAD

İbiş, Emsal - Erdoğan, Metin. “The Effects of SNPs Between Exons 6-9 in the STAT5A Gene on Milk Yield in Anatolian Buffalo”. Ankara Üniversitesi Veteriner Fakültesi Dergisi 73/1 (January 1, 2026): 7-12. https://doi.org/10.33988/auvfd.1675808.

JAMA

1.İbiş E, Erdoğan M. The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo. Ankara Univ Vet Fak Derg. 2026;73:7–12.

MLA

İbiş, Emsal, and Metin Erdoğan. “The Effects of SNPs Between Exons 6-9 in the STAT5A Gene on Milk Yield in Anatolian Buffalo”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol. 73, no. 1, Jan. 2026, pp. 7-12, doi:10.33988/auvfd.1675808.

Vancouver

1.Emsal İbiş, Metin Erdoğan. The effects of SNPs between exons 6-9 in the STAT5A gene on milk yield in Anatolian buffalo. Ankara Univ Vet Fak Derg. 2026 Jan. 1;73(1):7-12. doi:10.33988/auvfd.1675808