Comparative effects of Lavandula angustifolia and Helichrysum arenarium on intra-abdominal adhesion formation

Servet Yalçın; Latif Emrah Yanmaz; Özlem Özmen

doi:10.33988/auvfd.1741979

Comparative effects of Lavandula angustifolia and Helichrysum arenarium on intra-abdominal adhesion formation

Abstract

Intra-abdominal adhesions are a common postoperative complication, often resulting in pain, infertility, or bowel obstruction. Despite various preventive measures, effective and safe treatment options remain limited. Recently, interest has grown in plant-derived agents with anti-inflammatory and antifibrotic properties. Lavandula angustifolia (LA) and Helichrysum arenarium (HA) oils are two such candidates, but their effects on adhesion formation have not been directly compared. This study aimed to evaluate and compare the impact of intraperitoneally administered LA and HA oils on adhesion development in a rat model using macroscopic, histopathological, and immunohistochemical methods. Intra-abdominal adhesions were induced using the ischemic button model, followed by intraperitoneal administration of sterile saline (control), LA (75 mg/kg), and HA (1500 mg/kg). On postoperative day 14, the animals were euthanized, and macroscopic adhesion scoring, histopathological evaluation, Picro-Sirius Red staining, and measurements of TGF-α, VEGF-α, TNF-α, and Caspase-3 levels were conducted. Macroscopic scores did not differ significantly among the groups (P=0.363). Fibrosis and inflammation scores were significantly higher in the HA group (P<0.001). Picro-Sirius red staining revealed marked fibrotic development in the HA group. Expression levels of TGF-α and VEGF-α were increased in the control and LA groups, whereas TNF-α and Caspase-3 expression levels were significantly increased in the HA group (P<0.05). LA and HA oils differentially affected intra-abdominal adhesion development, with HA inducing a more pronounced inflammatory and fibrotic response.

Keywords

Project Number

2024/1363

References

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Details

Primary Language

English

Subjects

Veterinary Surgery, Veterinary Pathology

Journal Section

Research Article

Authors

Servet Yalçın ^*
0009-0000-5455-8032
Türkiye

Latif Emrah Yanmaz
0000-0001-5890-8271
Türkiye

Özlem Özmen
0000-0002-1835-1082
Türkiye

Early Pub Date

April 2, 2026

Publication Date

-

Submission Date

July 14, 2025

Acceptance Date

March 14, 2026

Published in Issue

Year 2026 Number: Advanced Online Publication

DOI

https://doi.org/10.33988/auvfd.1741979

IZ

https://izlik.org/JA98PJ87NM

Cite

RIS / Bibtex

APA

Yalçın, S., Yanmaz, L. E., & Özmen, Ö. (2026). Comparative effects of Lavandula angustifolia and Helichrysum arenarium on intra-abdominal adhesion formation. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Advanced Online Publication. https://doi.org/10.33988/auvfd.1741979

AMA

1.Yalçın S, Yanmaz LE, Özmen Ö. Comparative effects of Lavandula angustifolia and Helichrysum arenarium on intra-abdominal adhesion formation. Ankara Univ Vet Fak Derg. 2026;(Advanced Online Publication). doi:10.33988/auvfd.1741979

Chicago

Yalçın, Servet, Latif Emrah Yanmaz, and Özlem Özmen. 2026. “Comparative Effects of Lavandula Angustifolia and Helichrysum Arenarium on Intra-Abdominal Adhesion Formation”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, no. Advanced Online Publication. https://doi.org/10.33988/auvfd.1741979.

EndNote

Yalçın S, Yanmaz LE, Özmen Ö (April 1, 2026) Comparative effects of Lavandula angustifolia and Helichrysum arenarium on intra-abdominal adhesion formation. Ankara Üniversitesi Veteriner Fakültesi Dergisi Advanced Online Publication

IEEE

[1]S. Yalçın, L. E. Yanmaz, and Ö. Özmen, “Comparative effects of Lavandula angustifolia and Helichrysum arenarium on intra-abdominal adhesion formation”, Ankara Univ Vet Fak Derg, no. Advanced Online Publication, Apr. 2026, doi: 10.33988/auvfd.1741979.

ISNAD

Yalçın, Servet - Yanmaz, Latif Emrah - Özmen, Özlem. “Comparative Effects of Lavandula Angustifolia and Helichrysum Arenarium on Intra-Abdominal Adhesion Formation”. Ankara Üniversitesi Veteriner Fakültesi Dergisi. Advanced Online Publication (April 1, 2026). https://doi.org/10.33988/auvfd.1741979.

JAMA

1.Yalçın S, Yanmaz LE, Özmen Ö. Comparative effects of Lavandula angustifolia and Helichrysum arenarium on intra-abdominal adhesion formation. Ankara Univ Vet Fak Derg. 2026. doi:10.33988/auvfd.1741979.

MLA

Yalçın, Servet, et al. “Comparative Effects of Lavandula Angustifolia and Helichrysum Arenarium on Intra-Abdominal Adhesion Formation”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, no. Advanced Online Publication, Apr. 2026, doi:10.33988/auvfd.1741979.

Vancouver

1.Servet Yalçın, Latif Emrah Yanmaz, Özlem Özmen. Comparative effects of Lavandula angustifolia and Helichrysum arenarium on intra-abdominal adhesion formation. Ankara Univ Vet Fak Derg. 2026 Apr. 1;(Advanced Online Publication). doi:10.33988/auvfd.1741979