Prostaglandin administration following aglepristone pretreatment accelerates mid-term pregnancy termination in queens

Gülşah Saral; Anıl Gürkan Aksu; Firdevs Binli; Volkan Ferahoğlu; Fatih Büyükbudak; Işıl Ünaldı; Murat Fındık; Serhan Serhat Ay

doi:10.33988/auvfd.1959727

Prostaglandin administration following aglepristone pretreatment accelerates mid-term pregnancy termination in queens

Abstract

Mid-term pregnancy termination in queens remains clinically challenging due to endocrine adaptations that reduce the efficacy of conventional abortifacient protocols. This study evaluated whether administration of prostaglandin (PG) following pretreatment with aglepristone (AGL) accelerated the onset and completion of abortion in mid-term pregnant queens. Thirty-five queens at 30–38 days of gestation were randomly allocated to five groups: AGL alone, AGL followed by oral misoprostol (MIS; 200 μg/queen) at 24 or 36 h, and AGL followed by subcutaneous cloprostenol (CLO; 5 μg/kg) at 24 or 36 h after the first AGL administration. Abortion outcomes included the time to abortion onset (TAO), time to abortion completion (TAC), abortion duration (AD), abortion induction rate (AIR) and abortion completion rate (ACR). Kaplan–Meier analysis results revealed significant differences between the treatment groups for both time to abortion onset and time to abortion completion (both P<0.001), whereas AIR and ACR did not differ statistically between the groups. No treatment-related adverse effects were observed. Serum progesterone concentrations changed significantly over time, whereas neither the treatment group effect nor the treatment group-by-time interaction was statistically significant. These findings suggest that AGL pretreatment may enhance uterine responsiveness to PG during mid-term pregnancy in queens, facilitating more rapid abortion without compromising safety. From a clinical perspective, CLO administration 24 h after AGL pretreatment appears to be a practical and time-efficient protocol for terminating of mid-term pregnancy in queens.

Keywords

Project Number

This study was supported by Ondokuz Mayıs University with the project number PYO.VET.1904.23.006.

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Details

Primary Language

English

Subjects

Veterinary Obstetrics and Gynecology

Journal Section

Research Article

Authors

Gülşah Saral
0000-0002-5584-3991
Türkiye

Anıl Gürkan Aksu
0000-0001-8630-9460
Türkiye

Firdevs Binli
0000-0001-9547-8776
Türkiye

Volkan Ferahoğlu
0000-0002-1553-9733
Türkiye

Fatih Büyükbudak
0000-0002-6993-2514
Türkiye

Işıl Ünaldı
0000-0002-5514-4162
Türkiye

Murat Fındık
0000-0003-1408-2548
Türkiye

Serhan Serhat Ay ^*
0000-0003-2116-5149
Türkiye

Early Pub Date

October 31, 2026

Publication Date

-

Submission Date

May 28, 2026

Acceptance Date

August 27, 2026

Published in Issue

Year 2026 Number: Advanced Online Publication

DOI

https://doi.org/10.33988/auvfd.1959727

IZ

https://izlik.org/JA22TY99DX

Cite

RIS / Bibtex

APA

Saral, G., Aksu, A. G., Binli, F., Ferahoğlu, V., Büyükbudak, F., Ünaldı, I., Fındık, M., & Ay, S. S. (2026). Prostaglandin administration following aglepristone pretreatment accelerates mid-term pregnancy termination in queens. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Advanced Online Publication. https://doi.org/10.33988/auvfd.1959727

AMA

1.Saral G, Aksu AG, Binli F, et al. Prostaglandin administration following aglepristone pretreatment accelerates mid-term pregnancy termination in queens. Ankara Univ Vet Fak Derg. 2026;(Advanced Online Publication). doi:10.33988/auvfd.1959727

Chicago

Saral, Gülşah, Anıl Gürkan Aksu, Firdevs Binli, et al. 2026. “Prostaglandin Administration Following Aglepristone Pretreatment Accelerates Mid-Term Pregnancy Termination in Queens”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, no. Advanced Online Publication. https://doi.org/10.33988/auvfd.1959727.

EndNote

Saral G, Aksu AG, Binli F, Ferahoğlu V, Büyükbudak F, Ünaldı I, Fındık M, Ay SS (October 1, 2026) Prostaglandin administration following aglepristone pretreatment accelerates mid-term pregnancy termination in queens. Ankara Üniversitesi Veteriner Fakültesi Dergisi Advanced Online Publication

IEEE

[1]G. Saral et al., “Prostaglandin administration following aglepristone pretreatment accelerates mid-term pregnancy termination in queens”, Ankara Univ Vet Fak Derg, no. Advanced Online Publication, Oct. 2026, doi: 10.33988/auvfd.1959727.

ISNAD

Saral, Gülşah - Aksu, Anıl Gürkan - Binli, Firdevs - Ferahoğlu, Volkan - Büyükbudak, Fatih - Ünaldı, Işıl - Fındık, Murat - Ay, Serhan Serhat. “Prostaglandin Administration Following Aglepristone Pretreatment Accelerates Mid-Term Pregnancy Termination in Queens”. Ankara Üniversitesi Veteriner Fakültesi Dergisi. Advanced Online Publication (October 1, 2026). https://doi.org/10.33988/auvfd.1959727.

JAMA

1.Saral G, Aksu AG, Binli F, Ferahoğlu V, Büyükbudak F, Ünaldı I, Fındık M, Ay SS. Prostaglandin administration following aglepristone pretreatment accelerates mid-term pregnancy termination in queens. Ankara Univ Vet Fak Derg. 2026. doi:10.33988/auvfd.1959727.

MLA

Saral, Gülşah, et al. “Prostaglandin Administration Following Aglepristone Pretreatment Accelerates Mid-Term Pregnancy Termination in Queens”. Ankara Üniversitesi Veteriner Fakültesi Dergisi, no. Advanced Online Publication, Oct. 2026, doi:10.33988/auvfd.1959727.

Vancouver

1.Gülşah Saral, Anıl Gürkan Aksu, Firdevs Binli, Volkan Ferahoğlu, Fatih Büyükbudak, Işıl Ünaldı, Murat Fındık, Serhan Serhat Ay. Prostaglandin administration following aglepristone pretreatment accelerates mid-term pregnancy termination in queens. Ankara Univ Vet Fak Derg. 2026 Oct. 1;(Advanced Online Publication). doi:10.33988/auvfd.1959727