Investigation of the long term effects of chronic white noise stress on learning in radial arm maze and behaviors in forced swim test

Abstract

The long-term effects of 100 dB chronic white noise stress (WNS), exposed during prenatal and adolescent periods, on some cognitive functions and behaviors in rats were investigated. For this purpose, 40 female Sprague Dawley rats and their 60 male offspring were used. Pregnant rats were divided into Prenatal Stress (PS) and Prenatal Control (PC) groups. Noise stress was applied to PS group between the 14th and 21st days of their pregnancy, while PC rats were left undisturbed. After weaning, 60 male pups of PS dams were assigned to prenatal + chronic postnatal stress (PSCS), prenatal stress + non stress (PSN) and Control (CON) groups. During the postnatal 30th and 51st days, WNS was applied to PSCS rats, while PSN and CON groups were left undisturbed. The effects of stress on adult male offspring were investigated using 8-arm radial maze and forced swimming tests. There were no significant differences among groups for cognition and behavior tests. These results indicate that chronic 100 dB WNS does not have log-term effects on cognitive functions and depression related behaviors of adult male offspring

Keywords

• cognition
• forced swim
• rats
• stress
• white noise

Kronik beyaz gürültü stresinin radyal labirentte öğrenme ve zorunlu yüzme testinde davranışlarüzerine olan uzun dönem etkilerinin araştırılması

Abstract

Çalışmada sıçanlarda prenatal ve adolesan dönemlerde uygulanan kronik, 100 dB şiddetindeki beyaz gürültü stresinin bazı davranışlar ve kognitif fonksiyonlar üzerine olan uzun dönem etkileri araştırılmıştır. Bu amaçla 40 adet dişi Sprague Dawley sıçan ve bunlardan elde edilen 60 erkek sıçan kullanıldı. Gebe dişiler Prenatal Stres (PS) ve Prenatal Kontrol (PK) grubu olmak üzere iki gruba ayrıldılar. Gebeliğin 14. ve 21. günleri arasında PS grubuna ses stresi uygulanırken, kontrol grubuna herhangi bir uygulama yapılmadı. Yavrular sütten kesildikten sonra PS grubu dişilerden elde edilen 60 adet erkek yavru prenatal stres + kronik postnatal stres (PSKS), prenatal stres + stres uygulanmayan (PSSU) ve Kontrol (KON) gruplarına ayrıldılar. PSKS grubu ratlara postnatal dönemin 30. ve 51. günleri arasında stres uygulaması yapılırken, PS ve KON grubundaki ratlara herhangi bir uygulama yapılmadı. Stresin etkileri erişkin erkek sıçanlarda sekiz kollu radyal labirent testi ve zorlamalı yüzme testi kullanılarak ölçüldü. Kognitif ve davranışsal testler açısından gruplar arasında önemli bir farklılık bulunmadı. Elde edilen sonuçlar kronik, 100 dB beyaz ses stresinin erişkin erkek sıçanlarda kognitif fonksiyonlar ve depresyonla ilişkili davranışlar üzerinde uzun dönem etkisinin olmadığını göstermektedir

Keywords

• beyaz gürültü
• kognisyon
• rat
• stres
• zorunlu yüzme

References

1. Abidin I, Yargiçoglu P, Agar A, Gümüslü S, Aydin S, Oztürk O, Sahin E (2004): The effect of chronic restraint stress on spatial learning and memory: relation to oxidant stress. Int J Neurosci, 114, 683-99.
2. Aguilera G (1998): Corticotrophin Releasing Hormone, Receptor Regulation and the Stress Response. Trends Endocrinol Metab, 9, 329-336.
3. Bowman RE (2005): Stress induced changes in spatial memory are sexually differentiated and vary across the lifespan. J Neuroendocrinol, 17, 526-535.
4. Bulduk S, Canbeyli R (2004): Effect of inescapable tones on behavioral despair in Wistar rats. Prog Neuropsychopharmacol Biol Psychiatry, 28, 471-475.
5. Campeau S, Dolan D, Akil H, Watson SJ (2002): c-fos mRNA induction in acute and chronic audiogenic stress: possible role of the orbitofrontal cortex in habituation. Stress, 5, 121-130.
6. Coppola CL, Enns RM, Grandin T (2006): Noise in the animal shelter environment: building design and the effects of daily noise exposure. J Appl Anim Welf Sci, 9, 1-7.
7. Cui B, Wu M, She X (2009): Effects of Chronic Noise Exposure on Spatial Learning and Memory of Rats in Relation to Neurotransmitters and NMDAR2B Alteration in the Hippocampus. J Occup Health, 51, 152-158.
8. Dal-Zotto S, Martí O, Armario A (2000): Influence of single or repeated experience of rats with forced swimming on behavioural and physiological responses to the stressor. Behav Brain Res, 114, 175-181.

9. Darnaudéry M, Dutriez I, Viltart O, Morley-Fletcher S, Maccari S (2004): Stress during gestation induces lasting effects on emotional reactivity of the dam rat. Behav Brain Res, 153, 211-216.
10. Dayas CV, Buller KM, Crane JW, Xu Y, Day TA (2001): Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups. Eur J Neurosci, 14, 1143-1152.
11. Isgor C, Kabbaj M, Akil H, Watson SJ (2004): Delayed effects of chronic variable stress during peripubertal- juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats. Hippocampus, 14, 636-648.
12. Kendler KS, Karkowski LM, Prescott CA (1999): Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry, 156, 837-841.
13. Luine V, Villegas M, Martinez C, McEwen BS (1994): Repeated stress causes reversible impairments of spatial memory performance. Brain Res, 639, 167-170.
14. Manikandan S, Padma MK, Srikumar R, Jeya Parthasarathy N, Muthuvel A, Sheela Devi R (2006): Effects of chronic noise stress on spatial memory of rats in relation to neuronal dendritic alteration and free radical- imbalance in hippocampus and medial prefrontal cortex. Neurosci Lett, 399, 17-22.
15. Marin MT, Cruz FC, Planeta CS (2007): Chronic restraint or variable stresses differently affect the behavior, corticosterone secretion and body weight in rats. Physiol Behav, 90, 29-35.
16. Marjut MA, Wallenius A (2004): The interaction of noise stress and personal project stress on subjective health. J Environ Psychol, 24, 167-177.
17. McEwen BS (2000): The neurobiology of stress: from serendipity to clinical relevance. Brain Res, 886, 172-189.
18. McLaughlin KJ, Gomez JL, Baran SE, Conrad CD (2007): The effects of chronic stress on hippocampal morphology and function: an evaluation of chronic restraint paradigms. Brain Res, 1161, 56-64.
19. Mello PB, Benetti F, Cammarota M, Izquierdo I (2008): Effects of acute and chronic physical exercise and stress on different types of memory in rats. An Acad Bras Cienc, 80, 301-309.
20. Park CR, Campbell AM, Diamond DM (2001): Chronic psychosocial stress impairs learning and memory and increases sensitivity to yohimbine in adult rats. Biol Psychiatry, 50, 994-1004.
21. Pijlman FT, Herremans AH, van de Kieft J, Kruse CG, van Ree JM (2003): Behavioural changes after different stress paradigms: prepulse inhibition increased after physical, but not emotional stress. Eur Neuropsychopharmacol, 13, 369-380.
22. Porsolt RD, Anton G, Blavet N, Jalfre M (1978): Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol, 47, 379-391.
23. Samson J, Sheeladevi R, Ravindran R, Senthilvelan M (2007): Stress response in rat brain after different durations of noise exposure. Neurosci Res, 7, 143-147.
24. Smith JW, Seckl JR, Evans AT, Costall B, Smythe JW (2004): Gestational stress induces post-partum depression- like behaviour and alters maternal care in rats. Psychoneuroendocrinology, 29, 227-244.
25. Sterlemann V, Rammes G, Wolf M, Liebl C, Ganea K, Müller MB, Schmidt MV (2010): Chronic social stress during adolescence induces cognitive impairment in aged mice. Hippocampus, 20, 540-549.
26. Swiergiel AH, Zhou Y, Dunn AJ (2007): Effects of chronic footshock, restraint and corticotropin-releasing factor on freezing, ultrasonic vocalization and forced swim behavior in rats. Behav Brain Res, 183, 178-187.
27. Veena J, Srikumar BN, Raju TR, Shankaranarayana Rao BS (2009): Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats. Neurosci Lett, 455, 178-182.