Süt sığırlarında enerjice düzeltilmiş süt veriminin genomik tahmin ve ilişki analizleri

Abstract

Süt sığırlarında, süt verimi (SV) için enerji dengesi ile metabolizmanın korunması önemlidir. SV için genetik ve genomik analizlerine olan ilgi son yıllarda önem kazanmıştır. Enerjice düzeltilmiş süt verimi (EDSV) konusunda ise SV'den farklı olarak daha az araştırma bulunmaktadır. Bu çalışmanın amacı EDSV'ye sebep olabilecek tek nükleotid polimorfizmlerini (TNP) belirlemek ve bunlar üzerinden farklı genomik modeller kullanarak genomik tahminler (GT) yapmaktır. Bu çalışmada daha önceden yayınlanmış bir veri seti kullanılarak, 773 Holstayn ineğe ait EDSV gözlemleri ile 62410 TNP ve çiftlik bilgileri incelenmiştir. 5. kromozom gibi kısa bir kromozomda (28446 TNP) ve 29. kromozomda (12776 TNP) GT için genomun diğer bölgelerine göre daha yüksek etki büyüklükleri belirlenmiştir. Bu durum 5. kromozomda yer alan major bir gen ile açıklanabilir. GT sonuçları EDSV ve EDSV kalıntıları ile elde edilmiş ve 10 katlı çapraz sorgulama ile 0,6422 ve 0,3529 doğruluk oranları bulunmuştur. Bu da ECYM'nin GT modellerinde orta doğrulukta kullanılabileceğini göstermiştir. Bu çalışmada; çiftlik etkilerinin GT doğruluklarında bir etkiye sahip olduğu gösterilmiştir. 

Keywords

• Enerjice düzeltilmiş süt verimi
• genom tabanlı ilişki analizi
• genomik seleksiyon
• süt verimi

Project Number

118O108

Genomic prediction and association analyses of energy corrected milk yield in dairy cows

Abstract

Energy balance plays a critical role in the maintenance of metabolism for producing milk yield (MY) in dairy cows. In recent years, there has been increasing interest in genetic and genomic analyses of MY. In contrast to MY there is much less information about genomic evaluation of energy corrected milk yield (ECMY). The purpose of this paper is to detect associated single nucleotide polymorphisms (SNPs) with ECMY and genomic prediction (GP) of ECMY using different genomic models with special reference to underlying genetic architecture of ECMY. In this study we used published data of 773 Holstein cows with phenotypic observations for ECMY and dairy farm information with 62410 SNPs. One interesting finding is that some short chromosomes as such chromosomes 5 (included 28446 SNP) and 29 (included 12776 SNP) had higher effects sizes compared with the rest of the genome. A possible explanation for these results may be related with the existence of major genes at the chromosome 5. The GP results showed that ECYM and residuals of ECYM, had the accuracies from a 10-fold cross validations as 0.6422 and 0.3529 respectively. It was found that ECMY could be used for GP due to moderate accuracies. Taken together, dairy farm effects suggest an impact for accuracies of GP.

Keywords

• Energy corrected milk yield
• genome wide association analyses
• genomic selection
• milk yield

Supporting Institution

TÜBİTAK

Project Number

118O108

Thanks

This work was supported by the computational resources obtained from Scientific and Technological Research Council of Turkey (TÜBİTAK), Grant No: 118O108.

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