Tongue plasmacytoma in a dog treated with adjuvant metronomic melphalan

Year 2025, Volume: 72 Issue: 1, 113 - 116, 01.01.2025

Sofia Saggioro Rezk , Cláudia Brandão , Sheila Rahal , Noeme Rocha , Mariana Sessa

https://doi.org/10.33988/auvfd.1297530

Abstract

A 9-year-old female crossbred dog was referred due to a tongue neoformation. A marginal resection was performed to proceed with the histopathological examination, which indicated malignant round cell neoplasia, and immunohistochemical staining diagnosed the mass as plasmacytoma. The owner refused another surgical intervention to extend margins and approach another growth verified on the ventral surface of the base of the tongue. Thus, the patient underwent three months of metronomic chemotherapy with melphalan. The disease progression was not detected after two years of follow-up. This report shows that daily low-dose melphalan may be used as an adjuvant treatment option for oral plasmacytoma in dogs when clean margins cannot be achieved.

Keywords

chemotherapy, extramedullary, immunostaining, lingual, oncology

Supporting Institution

This work was supported by Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil (Financing Code 001).

Thanks

The authors thank for the support of the Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil.

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