The Effect of Repeated Administration at Different Doses of Enrofloxacin on Hematological and Biochemical Parameters in Sheep

Abstract

Aim: The aim of this study is to determine the effects of repeated administration (once a day for five days) of intravenous at different doses (2.5-5 mg/kg) of enrofloxacin on hematological and biochemical parameters in healthy sheep. Materials and Methods: Twelve Akkaraman female sheep were used in this study. The animals were divided into two groups of 6 each. One group was injected intravenously (v. jugularis) with at the dose of 2.5 mg/kg enrofloxacin, and the other was injected intravenously with at the dose of 5 mg/kg enrofloxacin for 5 days. Blood samples were collected at 0 (Control) and 120 hours. Hematological parameters (WBC, RBC, HGB, HCT ve PLT) were determined in a blood cell counter and biochemical parameters (AST, ALT, ALP, GGT, cholesterol, triglyceride, albumin, blood urea nitrogen, creatinine, and total protein) were determined in an autoanalyzer. Results: There was no significant difference in hematological and biochemical parameters between the two groups. Conclusion: It has been shown to results of the study that repeated administration of intravenous at doses of 2.5 mg/kg and 5 mg/kg enrofloxacin in sheep does not cause a negative effect on clinical hematological and biochemical parameters. Keywords: Enrofloxacin, Sheep, Hematology, Biochemical Parameters

Keywords

• Enrofloxacin
• Sheep
• Hematology
• Biochemical Parameters

Koyunlarda Enrofloksasinin Farklı Dozlarda Tekrarlı Uygulamasının Hematolojik ve Biyokimyasal Parametrelere Etkisi

Abstract

Amaç: Bu araştırmanın amacı sağlıklı koyunlarda enrofloksasinin farklı dozlardaki (2.5-5 mg/kg) tekrarlayan (günde bir defa, 5 gün) damar içi uygulamasının hematolojik ve biyokimyasal parametrelere etkisini belirlemektir. Gereç ve Yöntem: Araştırmada Akkaraman ırkı 12 adet dişi koyun kullanıldı. Hayvanlar her grupta 6 adet olacak şekilde iki gruba ayrıldı. Enrofloksasin gruplardan birisine 2.5 mg/kg dozda diğerine ise 5 mg/kg dozda damar içi (v. jugularis) yolla günde bir defa 5 gün boyunca uygulandı. Kan örnekleri 0. (Kontrol) ve 120. saatlerde alındı. Hematolojik parametreler (WBC, RBC, HGB, HCT ve PLT) kan hücre sayım cihazında ve biyokimyasal parametreler (AST, ALT, ALP, GGT, kolesterol, trigliserid, albümin, kan üre nitrojen, kreatinin ve total protein) otoanalizör cihazında ölçüldü. Bulgular: Deney grupları arasında hematolojik ve biyokimyasal parametrelerde önemli bir farklılık belirlenemedi. Sonuç: Koyunlarda 2.5 mg/kg ve 5 mg/kg dozlarda damar içi yolla enrofloksasinin tekrarlayan uygulamalarının hematolojik ve biyokimyasal parametrelerde olumsuz bir etkiye yol açmadığı kanaatine varılmıştır. Anahtar kelimeler: Enrofloksasin, Koyun, Hematoloji, Biyokimyasal Parametreler

Keywords

• Enrofloksasin
• Koyun
• Hematoloji
• Biyokimayasal Parametreler

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