PKOS Hastalarında Yüksek Kan Basıncı Sıklığı ve Bunun Klinik ve Laboratuvar Parametrelerle İlişkisi

Yıl 2021, Cilt: 10 Sayı: 2, 173 - 179, 31.08.2021

Özgür Bulmuş Akın Usta

https://doi.org/10.53424/balikesirsbd.962549

Bu makale için 28 Şubat 2022 tarihinde bir düzeltme yayımlandı. https://dergipark.org.tr/tr/pub/balikesirsbd/issue/68679/1082975

Öz

Amaç: Polikistik over sendromlu (PKOS) hastalarda kan basıncı (KB) anormalliklerine sıklıkla rastlanmakla beraber hipertansiyon ve PKOS arasındaki ilişki tam olarak aydınlatılamamıştır. Bu çalışmadaki amacımız ACC/AHA tarafından önerilen yeni sınıflandırmaya göre PKOS’lu hastalarda KB değişikliklerini araştırmaktır. Gereç Yöntem: Çalışmada PKOS tanılı 64 hasta ile aynı yaş grubundaki PKOS olmayan 61 hastanın KB ölçümleri ve bazal karakteristik özellikleri birbiri ile karşılaştırıldı. Bulgular: Kontrol grubuyla karşılaştırıldığında, PKOS hastalarının Ferriman Gallwey skoru (p<0.0001), ortalama diyastolik kan basıncı (p= 0.0099), glukoz (p=0.0049), lökosit (p= 0.0319), nötrofil (p=0.0364) ve Lüteinizan Hormon (LH) (p=0.0018) seviyeleri istatistiksel anlamlı olarak daha yüksek bulundu. PKOS ve Kontrol grubu ACC/AHA klavuzuna göre gruplandırıldığında PKOS hastalarının %59.4’ü anormal KB sahipken kontrol grubundaki hastaların ise %47.5’inde anormal KB tespit edildi. Yapılan istatistik analizde gruplar arasında anlamlı fark tespit edildi (p=0.0343). PKOS hastalarında DKB seviyeleri ile VKİ, serum glukoz seviyesi, HOMA-IR, total kolesterol ve LDL kolesterol arasında pozitif korelasyon tespit edildi. Ayrıca PKOS hastalarında DKB ile HDL kolesterol seviyeleri arasında negatif korelasyon tespit edildi. Sonuç: Üreme dönemindeki PKOS hastalarında KB (özellikle DKB) seviyelerinin insülin direnci, hiperandrojenemi ve dislipideminin varlığıyla ilişkili olarak yükselme eğiliminde olduğu, fakat PKOS ve kontrol grubu arasında hipertansiyon görülme sıklığı açısından fark olmadığı tespit edilmiştir.

Anahtar Kelimeler

PKOS, Hipertansiyon, ACC/AHA Guideline Sınıflaması

The Incidance of High Blood Pressure in Women with PCOS and Its Correlation with Clinical and Biochemical Parameters

Bu makale için 28 Şubat 2022 tarihinde bir düzeltme yayımlandı. https://dergipark.org.tr/tr/pub/balikesirsbd/issue/68679/1082975

Öz

Aim: Although blood pressure abnormalities are frequently encountered in patients with polycystic ovary syndrome (PCOS), the relationship between hypertension and PCOS has not been fully elucidated. Our aim of this study is to investigate BP alteration in patients with PCOS according to the new classification proposed by ACC/AHA guideline. Material and Methods: In this study, we compared the BP measurements and baseline characteristics of 64 patients with PCOS and 61 patients without PCOS in the same age group. Results: Compared with the control group, PCOS patients had increased Ferriman Gallwey score (p<0.0001), mean diastolic blood pressure (p=0.0099), glucose levels (p=0.0049), leukocyte counts (p=0.0319), neutrophil counts (p=0.0364) and LH levels (p=0.0018). When the PCOS and Control patients were classified according to the ACC/AHA guideline, 59.4% of the PCOS patients had abnormal BP, while 47.5% of the patients in the control group had abnormal BP. There was a statistically significant differences between the groups (p=0.0343). The correlation analysis showed that there were positive correlation between DBP levels and BMI, serum glucose level, HOMA-IR, total cholesterol and LDL cholesterol in PCOS patients. In addition, there was a negative correlation between DKB and HDL cholesterol levels in PCOS patients. Conclusion: It has been determined that BP (especially DBP) levels tend to increase in PCOS patients in the reproductive period in relation to the presence of insulin resistance, hyperandrogenemia and dyslipidemia, but there is no difference in the incidence of hypertension between PCOS and control groups.

Anahtar Kelimeler

PCOS, Hypertension, ACC/AHA Guideline Classification

Kaynakça

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