BibTex RIS Kaynak Göster

The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats

Yıl 2012, , 27 - 31, 23.06.2012
https://doi.org/10.17678/beuscitech.47149

Öz

The purpose of this study is to investigate the antioxidant effects Boric acid and CoQ10 has on Pulmonary Fibrosis in Bleomycin Induced Rats. 32 Wistar Albino male rats were used in this study. The rats were categorised in four groups; a control grou

Kaynakça

  • Aebi H (1984). Catalase in vitro. Method Enzymol 105, 121-126.
  • Averill-Bates D, Przybytkowski E (1994). The role of glucose in cellular defenses against cytotoxicity of hydrogen peroxide in Chinese hamster ovary cells. Arch Biochem Biophys 312, 52–58.
  • Baynes JW (1991). Role of oxidative stress in development of complications in diabetes. Diabet 40, 405-412.
  • Bélanger S, Lavorie JC, Chessex P (1997). Influence of bilirubin on the antioxidant capacity of plasma in newborn infants. Biol Neonate 71, 233–238.
  • Beydemir S, Çiftçi M, Küfrevioğlu OI, Büyükokuroğlu ME (2002). Effects of gentamicin sulfate on enzyme activities of carbonic anhydrase from human erythrocytes in vitro and from rat erythrocytes in vivo. Biol Pharm Bull 25, 966-969.
  • Bikle DD (2008). Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hy 17, 348–352.
  • Blackburn RV, Spitz DR, Liu X, Galoforo SS, Sim JE, Ridnour LA, Chen JC, Davis BH, Corry PM, Lee YJ (1999). Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. Free Radical Bio Med 26, 419–430.
  • Bourdon E,Blache D (2001). The importance of proteins in defense against oxidation. Antioxid Redox Sign 3, 293–311.
  • Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E (2006). Epidemic influenza and vitamin D. Epidemiol Infect 134, 1129–1140.
  • Chen H, Tappel AL (1995). Protection by vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, coenzyme Q10, beta carotene, canthaxantine, and (+)-catechin against oxidative damage to rat blood and tissues in vivo. Free Radical Bio Med 18, 949–953.
  • Chen J, Stubbe J (2005). Bleomycins: towards better therapeutics. Nat Rev Cancer 5,102–112.
  • Değer Y, Yur F, Ertekin A, Mert N, Dede S, Mert H (2007). Protective effect of alpha-tocopherol on oxidative stress in experimental pulmonary fibrosis in rats. Cell Biochem Funct 25, 633-637.
  • Dudnik LB, Tsyupko N, Khrenov AV, Alessenko AV (2001). Effect of bilirubin on lipid peroxidation, sphingomyelinase activity, and apoptosis induced by sphingosine and UV irrdatiation. Biochem 66, 1019– 1027.
  • Eren M, Kocaoğlu-Güçlü B, Uyanık F, Karabulut N (2006). The effects of dietary boron supplementation on performance, carcass composition and serum lipids in Japanese quails. J Anim Vet Adv 5, 5–8.
  • Ernster L, Dallner G (1995). Biochemical, physiological and medical aspects of ubiquinone function. Biochem Biophys Acta 1271, 95-204.
  • Ertekin A, Değer Y, Mert H, Mert N, Yur F, Dede S, Demir H (2007). Investigation of the effects of α-tocopherol on the levels of Fe, Cu, Zn, Mn and Carbonic Anhydrase in rats with bleomycin-induced pulmonary fibrosis. Biol Trace Elem Res 116, 289-300.
  • Frei B, Stocker R, Ames BN (1988). Antioxidant defenses and lipid peroxidation in human blood plasma. P Natl A Sci 85, 9748-9752.
  • Garcia-Gonzalez M, Mateo P, Bonilla I (1991). Boron requirement for envelope structure and function in Anabaena PCC 7119 heterocysts. J Exp Bot 42, 925– 929.
  • Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF (2006). The role of vitamin D in cancer prevention. Am J Public Health 96, 252–261.
  • Georgieff MK, Radmer WJ, Sowell AL, Yeager PR, Blaner WS, Gunter EW, Johnson DE (1991). The effect of glucocoticoids on serum, liver and lung vitamin A and retinyl ester concentration. J Pediatr Gastr Nutr 13, 376-382.
  • Giri NS, Nakashima JM, Curry DL (1985). Effects of intratracheal administration of bleomycin or saline in pair-fed and control-fed hamsters on daily food intake and on plasma levels of glucose, cortisol, and insulin, and lung levels of calmodulin, calcium, and collagen. Exp Mol Pathol 42, 206-219.
  • Heger RJ, Baybutt RC (1999). Regulation of polyamine synthesis and transport by retinoic acid and epidermal growth factor in cultured type II pneumocytes. J Nutr Biochem 10, 518-524.
  • Hernnäs J, Nettelbladt O, Bjermer L, Särnstrand B, Malmström A, Hällgren R (1992). Alveolar accumulation of fibronectin and hyaluronan precedes bleomycin-induced pulmonary fibrosis in the rat. Eur Respir J 4, 404-410.
  • Hunt CD (1996). Biochemical effects of physiological amounts of dietary boron. J Trace Elem Exp Med 9, 185–213.
  • Ihara H, Aoki Y, Hashizume N, Aoki T, Yoshida M, Osawa S (1998). Comparison of antioxidant activity of bilirubin species in vitro. Clin Chem Enzym Commun 8, 31–36.
  • Jordana M, Dolovich M, Irving LB, Tomioka M, Befus D, Gauldie J, Newhouse MT (1988). Solute movement across the alveolar-capillary membrane after intratracheally administered bleomycin in rats. Am Rev Respir Dis 138, 96-100.
  • Kato S, Kudo Y, Takahashi H, Osanai K, Yakuwa N, Nakamura H, Sato S, Takahashi K (1990). Effects of vitamin E deficiency on bleomycin induced pulmonary fibrosis in hamsters. Kok To Jun 38, 445- 450.
  • Krinsky NI (1992). Mechanism of action of biological antioxidants. Proc Soc Exp Biol Med 200, 248-254.
  • Lass A, Sohal RS (2000). Effect of coenzyme Q10 and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals. FASEB J 14, 87–94.
  • Liao SY, Brewer C, Závada J, Pastorek J, Pastoreková S, Manetta A (1994). Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas. Am J Pathol 145, 598–609.
  • Liu R, Ahmed KM, Nantajit D, Rosenthal FS, Hai C X, Li JJ (2007). Therapeutic effects of alpha-lipoic acid on bleomycin-induced pulmonary fibrosis in rats. Int J Mol Med 19, 865-73.
  • Mata M, Ruiz A, Cerda M, Martinez-Losa M, Cortijo J, Santangelo F, Serrano-Molar A, Llombart-Bosch A, Morcillo reducesbleomycin-induced lung damage and mucin Muc5ac expression in rats. Eur Respir J 22, 900–905.
  • Meacham SL, Taper LJ, Volpe SL (1994). Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes. Environ Health Persp 102, 79–82.
  • Mert H, Yörük I, Ertekin A, Dede S, Değer Y, Yur F, Mert N (2009). Vitamin levels in lung tissue of rats with bleomycin induced pulmonary fibrosis. J Nutr Sci Vitaminol 55,186-190.
  • Miller KW, Yang CS (1985). An isocratic high- performance liquid chromatography method for the simultaneous analysis of plasma retinol, α-tocopherol and various carotenoids. Anal Biochem 145, 21-26.
  • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A (2006). Serum 25- hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296, 2832–2838.
  • Nabeyrat E, Besnard V, Corroyer S, Cazals V, Clement A (1998). Retinoic acid-induced proliferation of lung alveolar epithelial cells: relation with the IGF system. Am J Physiol 275, 71-79.
  • Neužil J, Stocker R (1994). Free and albumin-bound bilirubin are efficient coantioxidants for alpha- tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem 24, 16712– 16719.
  • Özyurt H, Söğüt S, Yıldırım Z, Kart L, Iraz M, Armut F, Temel I, Özen S, Uzun A, Akyol O (2004). Inhibitory effect of caffeic acid phenethyl ester on bleomycine- induced lung fibrosis in rats. Clin Chim Acta 339, 65– 75.
  • Parlak E, Oğuz P, Şaşmaz N, Şahin T, Koşar Y, Kovalı E (1999). Coeliac disease, autoimmune thyroid disease and primary biliary cirrhosis: Case report. Turkish J Gastroenterol 10, 167-170.
  • Reynolds SL, Judd HJ (1984). Rapid procedure for the determination of vitamins a and d in fortified skimmed milk powder using high-performance liquid chromatography. Analyst 109, 489-492.
  • Rickli EE, Ghazanfar SAS, Gibbons BH, Edsall JT (1964). Carbonicanhydrase Preparation and properties of two enzymes. J Bio Chem 239, 1065-1078. human erytrocytes.
  • Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E (2008). The antioxidant properties of serum albumin. FEBS Lett 582,1783–1787.
  • Shi H, Noguchi N, Niki E (1999). Comparative study on Dynamics of antioxidative action of tocopheryl hydroquinone, ubiquinol, and tocopherol against lipid peroxidation. Free Radical Bio Med 27, 334–346.
  • Simi L, Venturini G, Malentacchi F, Gelmini S, Andreani M, Janni A, Pastorekova S, Supuran CT, Pazzagli M, Orlando C (2006). Qua ntitative analysis of carbonic anhydrase IX mRNA in human non-small cell lung cancer. Lung Cancer 52, 59–66.
  • Sleijfer S (2001). Bleomycin-induced pneumonitis. Chest 120, 617–624.
  • Şahin T (2006). Postoperatif erken dönemde cerrahi travma, oksidatif stres ve serum albümini arasındaki ilişki. Sağlık Bilimleri Enstitüsü, Uzmanlık Tezi, Gazi Üniversitesi Tıp Fakültesi, 50 s.
  • Tabata B, Kadokawa Y, Tabata R, Takahashi M, Okoshi K, Sakai Y, Mishima M, Kubo H (2006). All-trans-retinoic acid prevents radiation or bleomycin-induced pulmonary fibrosis. Am J Resp Crit Care 174, 1352- 1360.
  • Taooka Y, Maeda A, Hiyama K, Ishioka S, Yamakido M, (1997). Effects of neutrophils elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med, 156, 260–265.
  • Tashian RE, Hewett-Emmet D, Venta PJ (1991). In diversity and evolution in the carbonic anhydrase gene family, F. Botrè, G. Gros, B.T. Storey, eds., VCH Verlagsgesellschaft, Weinheim.
  • Turkez H, Geyikoğlu F, Tatar A, Keles S, Özkanç A (2007). Effects of some boron compounds on peripheral human blood. Z Naturforsch 62, 889–896.
  • Türe ÖT, Salepçi T, Sargın H, Koç Y, Yayla A (2002). Multiple myelom tanısı ile takip ve tedavisi düzenlenen olguların klinik ve patolojik durumlarının retrospektif analizi. Kartal Eğt Arşt Hast Tıp Derg 13, 83-86.
  • Wang JZ, Zhang H, Zhang M, Yao WT, Mao XY, Ren FZ (2008). Antioxidant activity of hydrolysates and peptide fractions of porcine plasma albumin and globulin. J Food Biochem 32, 693–707.
  • Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D’Agostino RB, Wolf M, Vasan RS (2008). Vitamin D deficiency and risk of cardiovascular disease. Circul 117, 503–511.
  • Yen HC, Chang HM, Fan-Yi Chen HM, Li SH (2005). Levels of reactive oxygen species and primary antioxidant enzymes in WI38 versus transformed WI38 cells following bleomcyin treatment. Free Radical Bio Med 38, 950–959.
  • Yoshimoto M, Wang S, Fukunaga K, Fournier D, Walde P, Kuboi R, Nakao K (2005). Novel immobilized liposomal glucose oxidase system using the channel protein OmpF and catalase. Biotechnol Bioeng 90, 231–238.
  • Zaspel BJ, Csallany S (1983). Determination of alpha- tocopherol in tissues and plasma by high- performance liquid chromatography. Anal Biochem 130, 146-150.
Yıl 2012, , 27 - 31, 23.06.2012
https://doi.org/10.17678/beuscitech.47149

Öz

Kaynakça

  • Aebi H (1984). Catalase in vitro. Method Enzymol 105, 121-126.
  • Averill-Bates D, Przybytkowski E (1994). The role of glucose in cellular defenses against cytotoxicity of hydrogen peroxide in Chinese hamster ovary cells. Arch Biochem Biophys 312, 52–58.
  • Baynes JW (1991). Role of oxidative stress in development of complications in diabetes. Diabet 40, 405-412.
  • Bélanger S, Lavorie JC, Chessex P (1997). Influence of bilirubin on the antioxidant capacity of plasma in newborn infants. Biol Neonate 71, 233–238.
  • Beydemir S, Çiftçi M, Küfrevioğlu OI, Büyükokuroğlu ME (2002). Effects of gentamicin sulfate on enzyme activities of carbonic anhydrase from human erythrocytes in vitro and from rat erythrocytes in vivo. Biol Pharm Bull 25, 966-969.
  • Bikle DD (2008). Vitamin D and the immune system: role in protection against bacterial infection. Curr Opin Nephrol Hy 17, 348–352.
  • Blackburn RV, Spitz DR, Liu X, Galoforo SS, Sim JE, Ridnour LA, Chen JC, Davis BH, Corry PM, Lee YJ (1999). Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. Free Radical Bio Med 26, 419–430.
  • Bourdon E,Blache D (2001). The importance of proteins in defense against oxidation. Antioxid Redox Sign 3, 293–311.
  • Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E (2006). Epidemic influenza and vitamin D. Epidemiol Infect 134, 1129–1140.
  • Chen H, Tappel AL (1995). Protection by vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, coenzyme Q10, beta carotene, canthaxantine, and (+)-catechin against oxidative damage to rat blood and tissues in vivo. Free Radical Bio Med 18, 949–953.
  • Chen J, Stubbe J (2005). Bleomycins: towards better therapeutics. Nat Rev Cancer 5,102–112.
  • Değer Y, Yur F, Ertekin A, Mert N, Dede S, Mert H (2007). Protective effect of alpha-tocopherol on oxidative stress in experimental pulmonary fibrosis in rats. Cell Biochem Funct 25, 633-637.
  • Dudnik LB, Tsyupko N, Khrenov AV, Alessenko AV (2001). Effect of bilirubin on lipid peroxidation, sphingomyelinase activity, and apoptosis induced by sphingosine and UV irrdatiation. Biochem 66, 1019– 1027.
  • Eren M, Kocaoğlu-Güçlü B, Uyanık F, Karabulut N (2006). The effects of dietary boron supplementation on performance, carcass composition and serum lipids in Japanese quails. J Anim Vet Adv 5, 5–8.
  • Ernster L, Dallner G (1995). Biochemical, physiological and medical aspects of ubiquinone function. Biochem Biophys Acta 1271, 95-204.
  • Ertekin A, Değer Y, Mert H, Mert N, Yur F, Dede S, Demir H (2007). Investigation of the effects of α-tocopherol on the levels of Fe, Cu, Zn, Mn and Carbonic Anhydrase in rats with bleomycin-induced pulmonary fibrosis. Biol Trace Elem Res 116, 289-300.
  • Frei B, Stocker R, Ames BN (1988). Antioxidant defenses and lipid peroxidation in human blood plasma. P Natl A Sci 85, 9748-9752.
  • Garcia-Gonzalez M, Mateo P, Bonilla I (1991). Boron requirement for envelope structure and function in Anabaena PCC 7119 heterocysts. J Exp Bot 42, 925– 929.
  • Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF (2006). The role of vitamin D in cancer prevention. Am J Public Health 96, 252–261.
  • Georgieff MK, Radmer WJ, Sowell AL, Yeager PR, Blaner WS, Gunter EW, Johnson DE (1991). The effect of glucocoticoids on serum, liver and lung vitamin A and retinyl ester concentration. J Pediatr Gastr Nutr 13, 376-382.
  • Giri NS, Nakashima JM, Curry DL (1985). Effects of intratracheal administration of bleomycin or saline in pair-fed and control-fed hamsters on daily food intake and on plasma levels of glucose, cortisol, and insulin, and lung levels of calmodulin, calcium, and collagen. Exp Mol Pathol 42, 206-219.
  • Heger RJ, Baybutt RC (1999). Regulation of polyamine synthesis and transport by retinoic acid and epidermal growth factor in cultured type II pneumocytes. J Nutr Biochem 10, 518-524.
  • Hernnäs J, Nettelbladt O, Bjermer L, Särnstrand B, Malmström A, Hällgren R (1992). Alveolar accumulation of fibronectin and hyaluronan precedes bleomycin-induced pulmonary fibrosis in the rat. Eur Respir J 4, 404-410.
  • Hunt CD (1996). Biochemical effects of physiological amounts of dietary boron. J Trace Elem Exp Med 9, 185–213.
  • Ihara H, Aoki Y, Hashizume N, Aoki T, Yoshida M, Osawa S (1998). Comparison of antioxidant activity of bilirubin species in vitro. Clin Chem Enzym Commun 8, 31–36.
  • Jordana M, Dolovich M, Irving LB, Tomioka M, Befus D, Gauldie J, Newhouse MT (1988). Solute movement across the alveolar-capillary membrane after intratracheally administered bleomycin in rats. Am Rev Respir Dis 138, 96-100.
  • Kato S, Kudo Y, Takahashi H, Osanai K, Yakuwa N, Nakamura H, Sato S, Takahashi K (1990). Effects of vitamin E deficiency on bleomycin induced pulmonary fibrosis in hamsters. Kok To Jun 38, 445- 450.
  • Krinsky NI (1992). Mechanism of action of biological antioxidants. Proc Soc Exp Biol Med 200, 248-254.
  • Lass A, Sohal RS (2000). Effect of coenzyme Q10 and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals. FASEB J 14, 87–94.
  • Liao SY, Brewer C, Závada J, Pastorek J, Pastoreková S, Manetta A (1994). Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas. Am J Pathol 145, 598–609.
  • Liu R, Ahmed KM, Nantajit D, Rosenthal FS, Hai C X, Li JJ (2007). Therapeutic effects of alpha-lipoic acid on bleomycin-induced pulmonary fibrosis in rats. Int J Mol Med 19, 865-73.
  • Mata M, Ruiz A, Cerda M, Martinez-Losa M, Cortijo J, Santangelo F, Serrano-Molar A, Llombart-Bosch A, Morcillo reducesbleomycin-induced lung damage and mucin Muc5ac expression in rats. Eur Respir J 22, 900–905.
  • Meacham SL, Taper LJ, Volpe SL (1994). Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes. Environ Health Persp 102, 79–82.
  • Mert H, Yörük I, Ertekin A, Dede S, Değer Y, Yur F, Mert N (2009). Vitamin levels in lung tissue of rats with bleomycin induced pulmonary fibrosis. J Nutr Sci Vitaminol 55,186-190.
  • Miller KW, Yang CS (1985). An isocratic high- performance liquid chromatography method for the simultaneous analysis of plasma retinol, α-tocopherol and various carotenoids. Anal Biochem 145, 21-26.
  • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A (2006). Serum 25- hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296, 2832–2838.
  • Nabeyrat E, Besnard V, Corroyer S, Cazals V, Clement A (1998). Retinoic acid-induced proliferation of lung alveolar epithelial cells: relation with the IGF system. Am J Physiol 275, 71-79.
  • Neužil J, Stocker R (1994). Free and albumin-bound bilirubin are efficient coantioxidants for alpha- tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem 24, 16712– 16719.
  • Özyurt H, Söğüt S, Yıldırım Z, Kart L, Iraz M, Armut F, Temel I, Özen S, Uzun A, Akyol O (2004). Inhibitory effect of caffeic acid phenethyl ester on bleomycine- induced lung fibrosis in rats. Clin Chim Acta 339, 65– 75.
  • Parlak E, Oğuz P, Şaşmaz N, Şahin T, Koşar Y, Kovalı E (1999). Coeliac disease, autoimmune thyroid disease and primary biliary cirrhosis: Case report. Turkish J Gastroenterol 10, 167-170.
  • Reynolds SL, Judd HJ (1984). Rapid procedure for the determination of vitamins a and d in fortified skimmed milk powder using high-performance liquid chromatography. Analyst 109, 489-492.
  • Rickli EE, Ghazanfar SAS, Gibbons BH, Edsall JT (1964). Carbonicanhydrase Preparation and properties of two enzymes. J Bio Chem 239, 1065-1078. human erytrocytes.
  • Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E (2008). The antioxidant properties of serum albumin. FEBS Lett 582,1783–1787.
  • Shi H, Noguchi N, Niki E (1999). Comparative study on Dynamics of antioxidative action of tocopheryl hydroquinone, ubiquinol, and tocopherol against lipid peroxidation. Free Radical Bio Med 27, 334–346.
  • Simi L, Venturini G, Malentacchi F, Gelmini S, Andreani M, Janni A, Pastorekova S, Supuran CT, Pazzagli M, Orlando C (2006). Qua ntitative analysis of carbonic anhydrase IX mRNA in human non-small cell lung cancer. Lung Cancer 52, 59–66.
  • Sleijfer S (2001). Bleomycin-induced pneumonitis. Chest 120, 617–624.
  • Şahin T (2006). Postoperatif erken dönemde cerrahi travma, oksidatif stres ve serum albümini arasındaki ilişki. Sağlık Bilimleri Enstitüsü, Uzmanlık Tezi, Gazi Üniversitesi Tıp Fakültesi, 50 s.
  • Tabata B, Kadokawa Y, Tabata R, Takahashi M, Okoshi K, Sakai Y, Mishima M, Kubo H (2006). All-trans-retinoic acid prevents radiation or bleomycin-induced pulmonary fibrosis. Am J Resp Crit Care 174, 1352- 1360.
  • Taooka Y, Maeda A, Hiyama K, Ishioka S, Yamakido M, (1997). Effects of neutrophils elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med, 156, 260–265.
  • Tashian RE, Hewett-Emmet D, Venta PJ (1991). In diversity and evolution in the carbonic anhydrase gene family, F. Botrè, G. Gros, B.T. Storey, eds., VCH Verlagsgesellschaft, Weinheim.
  • Turkez H, Geyikoğlu F, Tatar A, Keles S, Özkanç A (2007). Effects of some boron compounds on peripheral human blood. Z Naturforsch 62, 889–896.
  • Türe ÖT, Salepçi T, Sargın H, Koç Y, Yayla A (2002). Multiple myelom tanısı ile takip ve tedavisi düzenlenen olguların klinik ve patolojik durumlarının retrospektif analizi. Kartal Eğt Arşt Hast Tıp Derg 13, 83-86.
  • Wang JZ, Zhang H, Zhang M, Yao WT, Mao XY, Ren FZ (2008). Antioxidant activity of hydrolysates and peptide fractions of porcine plasma albumin and globulin. J Food Biochem 32, 693–707.
  • Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D’Agostino RB, Wolf M, Vasan RS (2008). Vitamin D deficiency and risk of cardiovascular disease. Circul 117, 503–511.
  • Yen HC, Chang HM, Fan-Yi Chen HM, Li SH (2005). Levels of reactive oxygen species and primary antioxidant enzymes in WI38 versus transformed WI38 cells following bleomcyin treatment. Free Radical Bio Med 38, 950–959.
  • Yoshimoto M, Wang S, Fukunaga K, Fournier D, Walde P, Kuboi R, Nakao K (2005). Novel immobilized liposomal glucose oxidase system using the channel protein OmpF and catalase. Biotechnol Bioeng 90, 231–238.
  • Zaspel BJ, Csallany S (1983). Determination of alpha- tocopherol in tissues and plasma by high- performance liquid chromatography. Anal Biochem 130, 146-150.
Toplam 57 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Fatih Çağlar Çelikezen Bu kişi benim

Gökhan Oto Bu kişi benim

Hülya Özdemir Bu kişi benim

Ufuk Kömüroğlu Bu kişi benim

İbrahim Yörük Bu kişi benim

Halit Demir Bu kişi benim

Aslı Çilingir Yeltekin Bu kişi benim

Yayımlanma Tarihi 23 Haziran 2012
Gönderilme Tarihi 16 Ocak 2012
Yayımlandığı Sayı Yıl 2012

Kaynak Göster

IEEE F. Ç. Çelikezen, G. Oto, H. Özdemir, U. Kömüroğlu, İ. Yörük, H. Demir, ve A. Ç. Yeltekin, “The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats”, Bitlis Eren University Journal of Science and Technology, c. 2, sy. 1, ss. 27–31, 2012, doi: 10.17678/beuscitech.47149.