Nutrigenomik - Transkriptomik, metabolomik, epigenomik ve proteomik gibi modern araçları kullanarak besinler ve insan genomu arasındaki ilişkilerin açıklığa kavuşmadığı gelişen bir bilim ve teknoloji alanı

Abstract

Nutrigenomik, sağlık ve hastalık yönetimine yönelik yeni alanlar açma potansiyeline sahip olan gelecek bilimlerden birisidir. İnsan genetiğinin ve ilgili ortamın dikkate alındığı sağlık sektöründe sağlık ve hastalık yönetimine daha önce genelleştirilmiş yaklaşım uygulanmış, buna rağmen bu çağdaş yaklaşımda beslenme ve insan genomu ile etkileşimi odak noktasındadır. Beslenme ve insan genomikleri ve bunların etkileşimi ile ilgili olarak, nutrigenetik ve nutrigenomik olmak üzere iki terim kullanılır, ancak bu terimlerin her ikisi de içeriğe bağlı olarak uzak ve yakından ilişkilidir. Konuyla ilgili yapılan çeşitli farklı araştırmalara göre, besin maddelerinin geni ve ekspresyonunu etkileme potansiyeli olduğunu ortaya koymuştur. Besin maddeleri, tüm seviyelerde genlerin genel işleyişini etkileyebilecek nitelikli ajanlar olarak hizmet eder. Çeşitli yönleri ortaya çıkarmak ve konuyla ilgili anlayışımızı derinleştirmek için çeşitli yaklaşımlar - daha kesin olarak 'OMIK' bilimleri kullanılmaktadır. Transkriptomik, Proteomik, Metabolomik ve Epigenomik bu amaca büyük hizmet eder. Nutrigenomik, bize sağlık ve hastalık yönetimine daha özelleştirilmiş, kişiye özel ve kişiye özel yaklaşım sağlayacak devrimci bir bilimsel yaklaşım olarak öngörülmüştür.

Keywords

• epigenomik
• metabolomik
• nutrigenomik
• proteomik
• transkriptomik

Nutrigenomics - An emerging field of science and technology unrevealing inter-relationships between nutrients and human genome using modern tools such as transcriptomics, metabolomics, epigenomics and proteomics

Abstract

Nutrigenomics is one of the upcoming sciences that have the potential to open up new arenas towards health and disease management. Earlier generalized approach towards health and disease management was employed in the health sector in which human genetics and its respective environment was taken into account, nevertheless in this contemporary approach nutrition and its interaction with human genome holds focal position. With regards to nutrition and human genomics and their interaction two terms as nutrigenetics and nutrigenomics are employed but both of these terms are distant as well as closely related depending upon the context. According to various different research studies conducted on the subject revealed that nutrients have the potential of influencing gene and its expression. Nutrients do serve as qualifying agents that can affect the overall functioning of genes at all levels. In order to uncover the various aspects and to deepen our comprehension on the subject various different approaches-more precisely ‘OMICS’ sciences are employed. Transcriptomics, Proteomics, Metabolomics and Epigenomics greatly serve the purpose. Nutrigenomics has been anticipated as a revolutionary scientific approach that will provide us with more customized, tailor-made and individual specific approach towards health and disease management. 

Keywords

• epigenomics
• metabolomics
• nutrigenomics
• proteomics
• transcriptomic

Thanks

Authors extend sincere thanks to the Atta-ur-Rahman School of Applied Biosciences, NUST, Islamabad from Pakistan, and Ege University as well as Hatay Mustafa Kemal University in Turkey for their full support in this and ongoing project collaborations.

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