Chronic mercury exposure: oxidative stress and neurotoxicity

Abstract

Mercury Hg is a bioaccumulative toxic metal that poses a high risk for human and environmental health through natural and anthropogenic emissions. Hg is an environmental toxic substance that causes neurological and developmental problems in biological systems. Although the molecular mechanisms mediating Hg-induced neurotoxicity are not fully understood, studies have shown that the oxidative stress created by this toxic substance has a critical effect on neurotoxicity. The purpose of this review is to summarize and discuss experimental and epidemiological studies that are important in elucidating oxidative damage to Hg and molecular events mediating neurotoxicity

Keywords

• mercury,oxidative stress,neurotoxicity,amyloid plaques,aquaporins

Kronik cıva maruziyeti: oksidatif stres ve nörotoksisite

Abstract

Cıva Hg , doğal ve antropojenik yayılımlarıyla insan ve çevre sağlığı için yüksek risk oluşturan biyoakümülatif özellikte toksik bir metaldir. Hg, biyolojik sistemlerde nörolojik ve gelişimsel problemlere neden olan çevresel kirletici bir maddedir. Hg kaynaklı nörotoksisiteye aracılık eden moleküler mekanizmalar tamamen anlaşılmamış olmasına rağmen, bu toksik maddenin yarattığı oksidatif stresin nörotoksisite üzerinde kritik bir öneme sahip olduğu yapılan çalışmalar ile ortaya konmaktadır. Bu derlemenin amacı, Hg'ye bağlı oksidatif hasarın ve nörotoksisiteye aracılık eden moleküler olayların aydınlatılmasında önemli olan deneysel ve epidemiyolojik çalışmaları özetlemek ve tartışmaktır

Keywords

• cıva,oksidatif stres,nörotoksisite,amiloid plaklar,akuaporinler

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