Anti-proliferative effect of Cistus laurifolius on human cervical adenocarcinoma (Hep2C), human muscle rhabdomyosarcoma (RD), mouse fibrosarcoma (Wehi 164) cell line

Abstract

In the current study; it was tried to determine antiproliferative activity of extract obtained from Cistus laurifolius leaves on different cancer cell type such as human cervical adenocarcinoma cells (Hep2C), human muscle rhabdomyosarcoma cells (RD), mouse fibrosarcoma cells (Wehi 164) by MTT Assay. The results indicated that Cistus laurifolius inhibited, in a dose-dependent manner, the proliferation of Hep2C, RD, Wehi 164 cells. Maximum anti-proliferatif effects were observed in 1000 µg/ml, 500 µg/ml, 250µg/ml concentrations of extract. These findings suggest that Cistus laurifolius extract could reduce proliferatif effect of cancer cell lines. Their use as potential anticancer agent needs further studies.

Keywords

• Cistus laurifolius
• human cervical adenocarcinoma cells (Hep2C)
• human muscle rhabdomyosarcoma cells (RD)
• mouse fibrosarcoma cells (Wehi 164)

Cistus laurifolius'un insan serviks karsinoma (Hep2C), insan kas rabdomyosarkoma (RD), fare fibrosarkoma (Wehi 164) hücre hatları üzerinde antiproliferatif etkisi

Abstract

Bu çalışmada; Cistus laurifolius ekstraktının; insan serviks karsinoma (Hep2C), insan kas rabdomyosarkoma (RD), fare fibrosarkoma (Wehi 164) hücre hatları üzerinde antiproliferatif aktivitesinin MTT testi aracılığı ile belirlenmesi amaçlanmıştır. Sonuç olarak, Cistus laurifolius ekstraktının doza bağlı bir şekilde, Hep2C, RD, Wehi 164 hücrelerinin proliferasyonunu inhibe ettiği tespit edilmiştir. Maksimum anti-proliferatif etki 1000 µg/ml, 500 µg/ml, 250µg/ml ekstrakt konsantrasyonlarında gözlenmiştir. Bu sonuçlar, Cistus laurifolius'nin kanser hücrelerinin proliferatif etkisini azaltabileceğini işaret etmektedir ve antikanser ajan olma potansiyeli konusunda daha ileri çalışmalar yapılmalıdır.

Keywords

• Cistus laurifolius
• insan serviks karsinoma (Hep2C)
• insan kas rabdomyosarkoma (RD)
• fare fibrosarkoma (Wehi 164)

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