The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists

Kardelen Tur; Fatih Mehmet Koca; Zeynep Sarımermer Yücel; Özge Al

The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists

Abstract

This study investigated the effects of chronic formaldehyde exposure on DNA damage and telomere length in anatomists working in anatomy laboratories. Peripheral blood samples were analyzed using the Comet Assay to assess DNA strand breaks and quantitative PCR (qPCR) to determine telomere length. The results showed significantly increased tail length, tail DNA percentage, and tail moment values in the exposed group compared with the controls (p <0.0001), indicating extensive DNA fragmentation. Furthermore, the mean telomere length of the exposed group (14.43 ± 3.00 kb) was approximately 72% shorter than that of the reference sample (52.26 kb). These findings demonstrate that formaldehyde induces both genotoxic and telomeric damage, contributing to cellular aging, genomic instability, and potentially an increased cancer risk, highlighting the need for biomarker-based monitoring and enhanced occupational safety practices among anatomists and laboratory professionals.

Keywords

References

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Details

Primary Language

English

Subjects

Cancer Biology, Genotoxicity and Cytotoxicity

Journal Section

Research Article

Authors

Kardelen Tur ^*
0000-0002-5790-9499
Türkiye

Fatih Mehmet Koca
0000-0002-5405-857X
Türkiye

Zeynep Sarımermer Yücel
0009-0008-4662-0957
Türkiye

Özge Al
0000-0001-5292-3593
Türkiye

Publication Date

December 30, 2025

Submission Date

November 16, 2025

Acceptance Date

December 24, 2025

Published in Issue

Year 2025 Number: 1

IZ

https://izlik.org/JA95WJ97NY

Cite

RIS / Bibtex

APA

Tur, K., Koca, F. M., Sarımermer Yücel, Z., & Al, Ö. (2025). The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists. Erciyes BioGenome, 1, 23-30. https://izlik.org/JA95WJ97NY

AMA

1.Tur K, Koca FM, Sarımermer Yücel Z, Al Ö. The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists. Erciyes BioGenome. 2025;(1):23-30. https://izlik.org/JA95WJ97NY

Chicago

Tur, Kardelen, Fatih Mehmet Koca, Zeynep Sarımermer Yücel, and Özge Al. 2025. “The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists”. Erciyes BioGenome, no. 1: 23-30. https://izlik.org/JA95WJ97NY.

EndNote

Tur K, Koca FM, Sarımermer Yücel Z, Al Ö (December 1, 2025) The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists. Erciyes BioGenome 1 23–30.

IEEE

[1]K. Tur, F. M. Koca, Z. Sarımermer Yücel, and Ö. Al, “The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists”, Erciyes BioGenome, no. 1, pp. 23–30, Dec. 2025, [Online]. Available: https://izlik.org/JA95WJ97NY

ISNAD

Tur, Kardelen - Koca, Fatih Mehmet - Sarımermer Yücel, Zeynep - Al, Özge. “The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists”. Erciyes BioGenome. 1 (December 1, 2025): 23-30. https://izlik.org/JA95WJ97NY.

JAMA

1.Tur K, Koca FM, Sarımermer Yücel Z, Al Ö. The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists. Erciyes BioGenome. 2025;:23–30.

MLA

Tur, Kardelen, et al. “The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists”. Erciyes BioGenome, no. 1, Dec. 2025, pp. 23-30, https://izlik.org/JA95WJ97NY.

Vancouver

1.Kardelen Tur, Fatih Mehmet Koca, Zeynep Sarımermer Yücel, Özge Al. The Effects of Formaldehyde Exposure on Telomere Length and DNA Damage in Anatomists. Erciyes BioGenome [Internet]. 2025 Dec. 1;(1):23-30. Available from: https://izlik.org/JA95WJ97NY