Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values

Mehmet Akçiçek; Gökçe Bağcı Uzun; Muhammed Furkan Arpacı; Emre Demirel; Hıdır Pekmez

Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values

Abstract

Hydronephrosis is a significant clinical condition characterized by dilatation of the renal collecting system, parenchymal thinning, and loss of volume due to increased intrapelvic pressure, leading to disruption of both the morphological and functional integrity of the kidney. In this study, renal volume and morphometric measurements were compared between individuals with and without hydronephrosis using computed tomography (CT) images, and the impact of hydronephrosis on renal volume and geometry was evaluated using three different volume measurement methods. This retrospective study included non-contrast abdominal CT scans obtained between 2017 and 2022. A total of 91 cases (50 with hydronephrosis and 41 without hydronephrosis) were evaluated. Renal volumes were calculated using semi-automatic segmentation with ITK-SNAP (Volsinak), manual area measurement with RadiAnt DICOM Viewer, and the ellipsoid formula method. Additionally, morphometric parameters such as renal thickness, width, length, polar distances (PSAD, PIAD), distances to the spinal medulla (PSMSD, PIMSD), and the angular measurement between the kidney and the transverse plane (BUTDANGLE) were assessed. The findings demonstrated significant differences in thickness, width, and BUTDANGLE parameters in hydronephrotic kidneys (p < 0.05), indicating that hydronephrosis disrupts not only kidney volume but also its geometric structure. A statistically significant difference was observed among the three volume measurement methods (p = 0.001), with the ellipsoid method tending to underestimate renal volume. In conclusion, this study reveals that hydronephrosis leads to marked structural and geometrical alterations in renal morphometry and volume values. It also highlights that three-dimensional semi-automatic segmentation-based methods provide more reliable assessments in renal volume analysis and contribute uniquely to the literature by incorporating novel morphometric parameters.

Keywords

References

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Details

Primary Language

English

Subjects

Nanobiotechnology

Journal Section

Research Article

Authors

Mehmet Akçiçek
0000-0002-0232-1284
Türkiye

Gökçe Bağcı Uzun ^*
0000-0003-4992-6915
Türkiye

Muhammed Furkan Arpacı
0000-0003-3083-0155
Türkiye

Emre Demirel
0000-0002-3101-2819
Türkiye

Hıdır Pekmez
0000-0002-4916-7675
Türkiye

Publication Date

December 30, 2025

Submission Date

November 20, 2025

Acceptance Date

December 26, 2025

Published in Issue

Year 2025 Number: 1

IZ

https://izlik.org/JA68JX98BD

Cite

RIS / Bibtex

APA

Akçiçek, M., Bağcı Uzun, G., Arpacı, M. F., Demirel, E., & Pekmez, H. (2025). Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values. Erciyes BioGenome, 1, 43-52. https://izlik.org/JA68JX98BD

AMA

1.Akçiçek M, Bağcı Uzun G, Arpacı MF, Demirel E, Pekmez H. Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values. Erciyes BioGenome. 2025;(1):43-52. https://izlik.org/JA68JX98BD

Chicago

Akçiçek, Mehmet, Gökçe Bağcı Uzun, Muhammed Furkan Arpacı, Emre Demirel, and Hıdır Pekmez. 2025. “Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values”. Erciyes BioGenome, no. 1: 43-52. https://izlik.org/JA68JX98BD.

EndNote

Akçiçek M, Bağcı Uzun G, Arpacı MF, Demirel E, Pekmez H (December 1, 2025) Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values. Erciyes BioGenome 1 43–52.

IEEE

[1]M. Akçiçek, G. Bağcı Uzun, M. F. Arpacı, E. Demirel, and H. Pekmez, “Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values”, Erciyes BioGenome, no. 1, pp. 43–52, Dec. 2025, [Online]. Available: https://izlik.org/JA68JX98BD

ISNAD

Akçiçek, Mehmet - Bağcı Uzun, Gökçe - Arpacı, Muhammed Furkan - Demirel, Emre - Pekmez, Hıdır. “Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values”. Erciyes BioGenome. 1 (December 1, 2025): 43-52. https://izlik.org/JA68JX98BD.

JAMA

1.Akçiçek M, Bağcı Uzun G, Arpacı MF, Demirel E, Pekmez H. Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values. Erciyes BioGenome. 2025;:43–52.

MLA

Akçiçek, Mehmet, et al. “Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values”. Erciyes BioGenome, no. 1, Dec. 2025, pp. 43-52, https://izlik.org/JA68JX98BD.

Vancouver

1.Mehmet Akçiçek, Gökçe Bağcı Uzun, Muhammed Furkan Arpacı, Emre Demirel, Hıdır Pekmez. Investigation of the Effects of Hydronephrosis on Renal Morphometry and Volume Values. Erciyes BioGenome [Internet]. 2025 Dec. 1;(1):43-52. Available from: https://izlik.org/JA68JX98BD