Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization

Büşranur Şenol; Ayşe Malbora; Mehmet Emin Şenol; Zehra Gül Morçimen

doi:10.38042/biotechstudies.1904228

Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization

Abstract

Electrospun nanofiber wound dressings potentially provide a highly suitable environment for healing compared to traditional wound dressings, which often fail to meet all the requirements of the wound healing process. This study aimed to develop PLGA nanofibers incorporating silver nanoparticles containing Echinacea extract for use as wound dressings; to perform their characterization tests, and evaluate their wound healing efficacy using in vitro models. Echinacea silver nanoparticles were synthesized using a green synthesis method. PLGA, silver nanoparticle containing PLGA (AgNP/PLGA), 1%, 2%, 3%, Echinacea silver nanoparticle containing PLGA (Ec-AgNP/PLGA) nanofibers were produced by electrospinning method. The nanofibers were characterized by SEM, FTIR, XRD and antibacterial analysis and evaluated using an in vitro wound scratch test. The average zone diameters of Ec-AgNP/PLGA nanofibers against the E. coli and S. aureus bacteria were found to be 13.5±0.3 mm. The antioxidant capacity analysis of the Echinacea extract used in the study was evaluated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and the percentage of DPPH radical removal was calculated as 46.8% and the ascorbic acid equivalent was determined as 35.5 µM. The results demonstrated that Echinacea significantly accelerated wound healing due to its therapeutic and antioxidant properties.

Keywords

Supporting Institution

This study is the master's thesis of Büşranur Şenol under the supervision of Assoc. Prof. Dr. Ayşe Malbora and was financially supported by Ege University Scientific Research Coordinatorship (BAP) under the project number FM-YLT-2022-75586. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. *Ege University Scientific Research Coordinatorship (BAP): https://bap.ege.edu.tr/

Project Number

FM-YLT-2022-75586

Thanks

We are grateful to Assoc. Prof. Dr. Aylin Şendemir and her team for their support in carrying out this study and for making all the equipment in their laboratory available to us. This work was supported by The Scientific Research Foundation of Ege University (Project number: FM-YLT-2022-75586).

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Details

Primary Language

English

Subjects

Nanomedicine

Journal Section

Research Article

Authors

Büşranur Şenol ^*
0000-0002-5657-5490
Türkiye

Ayşe Malbora
0000-0002-4235-3942
Türkiye

Mehmet Emin Şenol
0000-0002-5972-8798
Türkiye

Zehra Gül Morçimen
0000-0001-8954-9996
Türkiye

Publication Date

April 24, 2026

Submission Date

January 11, 2025

Acceptance Date

December 23, 2025

Published in Issue

Year 2026 Number: 35

DOI

https://doi.org/10.38042/biotechstudies.1904228

IZ

https://izlik.org/JA48TL28HA

Cite

RIS / Bibtex

APA

Şenol, B., Malbora, A., Şenol, M. E., & Morçimen, Z. G. (2026). Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization. Biotech Studies, 35. https://doi.org/10.38042/biotechstudies.1904228

AMA

1.Şenol B, Malbora A, Şenol ME, Morçimen ZG. Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization. Biotech Studies. 2026;(35). doi:10.38042/biotechstudies.1904228

Chicago

Şenol, Büşranur, Ayşe Malbora, Mehmet Emin Şenol, and Zehra Gül Morçimen. 2026. “Design of PLGA Nanofiber Wound Dressing Enriched With Echinacea Purpurea Extract and in Vitro Characterization”. Biotech Studies, nos. 35. https://doi.org/10.38042/biotechstudies.1904228.

EndNote

Şenol B, Malbora A, Şenol ME, Morçimen ZG (April 1, 2026) Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization. Biotech Studies 35

IEEE

[1]B. Şenol, A. Malbora, M. E. Şenol, and Z. G. Morçimen, “Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization”, Biotech Studies, no. 35, Apr. 2026, doi: 10.38042/biotechstudies.1904228.

ISNAD

Şenol, Büşranur - Malbora, Ayşe - Şenol, Mehmet Emin - Morçimen, Zehra Gül. “Design of PLGA Nanofiber Wound Dressing Enriched With Echinacea Purpurea Extract and in Vitro Characterization”. Biotech Studies. 35 (April 1, 2026). https://doi.org/10.38042/biotechstudies.1904228.

JAMA

1.Şenol B, Malbora A, Şenol ME, Morçimen ZG. Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization. Biotech Studies. 2026. doi:10.38042/biotechstudies.1904228.

MLA

Şenol, Büşranur, et al. “Design of PLGA Nanofiber Wound Dressing Enriched With Echinacea Purpurea Extract and in Vitro Characterization”. Biotech Studies, no. 35, Apr. 2026, doi:10.38042/biotechstudies.1904228.

Vancouver

1.Büşranur Şenol, Ayşe Malbora, Mehmet Emin Şenol, Zehra Gül Morçimen. Design of PLGA nanofiber wound dressing enriched with Echinacea purpurea extract and in vitro characterization. Biotech Studies. 2026 Apr. 1;(35). doi:10.38042/biotechstudies.1904228