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Yıl 2024, Cilt: 33 Sayı: 1, 52 - 66, 30.06.2024
https://doi.org/10.38042/biotechstudies.1463814

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Recent in vitro models and tissue engineering strategies to study glioblastoma

Yıl 2024, Cilt: 33 Sayı: 1, 52 - 66, 30.06.2024
https://doi.org/10.38042/biotechstudies.1463814

Öz

Glioblastoma is a highly malignant brain tumor classified as grade IV with a poor prognosis and approximately a year of survival rate. The molecular changes that trigger primary glioblastoma are usually epidermal growth factor receptor mutations and amplifications, Mouse Double Minute and TP53 mutations, p16 deletion, phosphatase and tensin homolog and telomerase promoter mutations. In the vast majority of glioblastomas, altered signaling pathways were identified as receptor tyrosine kinase/Ras/PI3K, p53. Isocitrate dehydrogenase 1/2 mutations have also been associated with poor prognosis in glioblastoma The treatment options are very limited and complicated because of the diverse composition and heterogeneity of the tumors and unresponsiveness to the treatments with the existence of barriers reaching the brain tissue. Despite new trials, drug candidates that appeared effective in cell culture or mouse models failed in the clinic. Recently, new sophisticated experimental systems, including the those that mimic the tumor microenvironment, have started being used by several research groups, which will allow accurate prediction of drug efficacy. Tissue engineering strategies are also being combined with innovative cancer models, including spheroids, tumorspheres, organotypic slices, explants, tumoroids, and organoids. Such 3D systems provide powerful tools for studying glioblastoma biology by representing the dynamic evolution of the disease from the early to the metastatic stages and enabling interaction with the microenvironment. In this review, we both enlighten the molecular mechanisms that lead to glioblastoma development and detailed information on the tissue engineering approaches that have been used to model glioblastoma and the tumor microenvironment with the advantages and disadvantages. We anticipate that these novel approaches could improve the reliability of preclinical data by reducing the need for animal models.

Kaynakça

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  • Soubéran, A., & Tchoghandjian, A. (2020). Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation. Cancers, 12(9), 1–21. https://doi.org/10.3390/CANCERS12092347
  • Srividya, M. R., Thota, B., Shailaja, B. C., Arivazhagan, A., Thennarasu, K., Chandramouli, B. A., Hegde, A. S., & Santosh, V. (2011). Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a prospective translational study on a uniformly treated cohort of adult patients. Neuropathology : Official Journal of the Japanese Society of Neuropathology, 31(4), 376–383. https://doi.org/10.1111/J.1440-1789.2010.01178.X
  • Stoyanov, G. S., Dzhenkov, D., Ghenev, P., Iliev, B., Enchev, Y., & Tonchev, A. B. (2018a). Cell biology of glioblastoma multiforme: from basic science to diagnosis and treatment. Medical Oncology (Northwood, London, England), 35(3). https://doi.org/10.1007/S12032-018-1083-X
  • Stoyanov, G. S., Dzhenkov, D., Ghenev, P., Iliev, B., Enchev, Y., & Tonchev, A. B. (2018b). Cell biology of glioblastoma multiforme: from basic science to diagnosis and treatment. Medical Oncology (Northwood, London, England), 35(3). https://doi.org/10.1007/S12032-018-1083-X
  • Sun, N., Meng, X., Liu, Y., Song, D., Jiang, C., & Cai, J. (2021). Applications of brain organoids in neurodevelopment and neurological diseases. Journal of Biomedical Science 2021 28:1, 28(1), 1–16. https://doi.org/10.1186/S12929-021-00728-4
  • Takahashi, M., Miki, S., Fujimoto, K., Fukuoka, K., Matsushita, Y., Maida, Y., Yasukawa, M., Hayashi, M., Shinkyo, R., Kikuchi, K., Mukasa, A., Nishikawa, R., Tamura, K., Narita, Y., Hamada, A., Masutomi, K., & Ichimura, K. (2019). Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts. Cancer Science, 110(7), 2247. https://doi.org/10.1111/CAS.14067
  • Tan, A. C., Ashley, D. M., López, G. Y., Malinzak, M., Friedman, H. S., & Khasraw, M. (2020a). Management of glioblastoma: State of the art and future directions. CA: A Cancer Journal for Clinicians, 70(4), 299–312. https://doi.org/10.3322/CAAC.21613
  • Tan, A. C., Ashley, D. M., López, G. Y., Malinzak, M., Friedman, H. S., & Khasraw, M. (2020b). Management of glioblastoma: State of the art and future directions. CA: A Cancer Journal for Clinicians, 70(4), 299–312. https://doi.org/10.3322/CAAC.21613
  • Tatla, A. S., Justin, A. W., Watts, C., & Markaki, A. E. (2021). A vascularized tumoroid model for human glioblastoma angiogenesis. Scientific Reports, 11(1), 19550. https://doi.org/10.1038/S41598-021-98911-Y
  • Tsang, L. L. H., Farmer, P. B., Gescher, A., & Slack, J. A. (1990). Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicity. Cancer Chemotherapy and Pharmacology, 26(6), 429–436. https://doi.org/10.1007/BF02994094
  • Uddin, M. S., Mamun, A. Al, Alghamdi, B. S., Tewari, D., Jeandet, P., Sarwar, M. S., & Ashraf, G. M. (2020). Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches. Seminars in Cancer Biology. https://doi.org/10.1016/J.SEMCANCER.2020.12.015
  • Van Den Bent, M. J., Gao, Y., Kerkhof, M., Kros, J. M., Gorlia, T., Van Zwieten, K., Prince, J., Van Duinen, S., Sillevis Smitt, P. A., Taphoorn, M., & French, P. J. (2015). Changes in the EGFR amplification and EGFRvIII expression between paired primary and recurrent glioblastomas. Neuro-Oncology, 17(7), 935–941. https://doi.org/10.1093/NEUONC/NOV013
  • Weiswald, L. B., Bellet, D., & Dangles-Marie, V. (2015). Spherical Cancer Models in Tumor Biology. Neoplasia (New York, N.Y.), 17(1), 1. https://doi.org/10.1016/J.NEO.2014.12.004
  • Weller, M., Butowski, N., Tran, D. D., Recht, L. D., Lim, M., Hirte, H., Ashby, L., Mechtler, L., Goldlust, S. A., Iwamoto, F., Drappatz, J., O’Rourke, D. M., Wong, M., Hamilton, M. G., Finocchiaro, G., Perry, J., Wick, W., Green, J., He, Y., Nag, S. (2017). Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial. The Lancet. Oncology, 18(10), 1373–1385. https://doi.org/10.1016/S1470-2045(17)30517-X
  • Wen, P. Y., Schiff, D., Cloughesy, T. F., Raizer, J. J., Laterra, J., Smitt, M., Wolf, M., Oliner, K. S., Anderson, A., Zhu, M., Loh, E., & Reardon, D. A. (2011). A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro-Oncology, 13(4), 437–446. https://doi.org/10.1093/NEUONC/NOQ198
  • Wick, W., Gorlia, T., Bady, P., Platten, M., Van Den Bent, M. J., Taphoorn, M. J. B., Steuve, J., Brandes, A. A., Hamou, M. F., Wick, A., Kosch, M., Weller, M., Stupp, R., Roth, P., Golfinopoulos, V., Frene, J. S., Campone, M., Ricard, D., Marosi, C., Hegi, M. E. (2016). Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082). Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 22(19), 4797–4806. https://doi.org/10.1158/1078-0432.CCR-15-3153
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  • Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., Friedman, H., Friedman, A., Reardon, D., Herndon, J., Kinzler, K. W., Velculescu, V. E., Vogelstein, B., & Bigner, D. D. (2009). IDH1 and IDH2 Mutations in Gliomas. The New England Journal of Medicine, 360(8), 765. https://doi.org/10.1056/NEJMOA0808710
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  • Zhang, C., Jin, M., Zhao, J., Chen, J., & Jin, W. (2020). Organoid models of glioblastoma: advances, applications and challenges. American Journal of Cancer Research, 10(8), 2242. /pmc/articles/PMC7471358/
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  • Zhao, W., Luo, Y., Li, B., & Zhang, T. (2016). Tumorigenic lung tumorospheres exhibit stem-like features with significantly increased expression of CD133 and ABCG2. Molecular Medicine Reports, 14(3), 2598–2606. https://doi.org/10.3892/MMR.2016.5524
  • Zheng, H., Ying, H., Yan, H., Kimmelman, A. C., Hiller, D. J., Chen, A. J., Perry, S. R., Tonon, G., Chu, G. C., Ding, Z., Stommel, J. M., Dunn, K. L., Wiedemeyer, R., You, M. J., Brennan, C., Wang, Y. A., Ligon, K. L., Wong, W. H., Chin, L., & DePinho, R. A. (2008). p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature, 455(7216), 1129–1133. https://doi.org/10.1038/NATURE07443
  • Zhu, H., Wang, H., Huang, Q., Liu, Q., Guo, Y., Lu, J., Li, X., Xue, C., & Han, Q. (2018). Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells. Frontiers in Molecular Neuroscience, 11. https://doi.org/10.3389/FNMOL.2018.00187
Toplam 84 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hücresel Etkileşimler , Rejeneratif Tıp (kök hücreler dahil), Tıbbi Biyoteknoloji (Diğer)
Bölüm Review
Yazarlar

Melike Karakaya Bu kişi benim 0000-0002-5029-3150

Pınar Obakan Yerlikaya 0000-0001-7058-955X

Erken Görünüm Tarihi 2 Nisan 2024
Yayımlanma Tarihi 30 Haziran 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 33 Sayı: 1

Kaynak Göster

APA Karakaya, M., & Obakan Yerlikaya, P. (2024). Recent in vitro models and tissue engineering strategies to study glioblastoma. Biotech Studies, 33(1), 52-66. https://doi.org/10.38042/biotechstudies.1463814


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