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The Combined Use of SCD Probiotics and Tauroursodeoksikolik Asit (TUDCA) is More Effective in Controlling Anxiety-Like Behavior in Aged Rats

Yıl 2023, , 242 - 246, 22.03.2023
https://doi.org/10.17798/bitlisfen.1231238

Öz

In this study, the effects of TUDCA administration with a SCD probiotics for one week on locomotors activity and anxious behavior were investigated. Male Saprague-Dawley rats aged 24 months were used as the model organism. At the end of the application, open-field and elevated plus maze behavioral tests were performed on the rats. Although SCD probiotics were more effective on anxious behavior, the group in which they were administered together had a significantly greater effect on locomotor activity and anxious behavior. This study provides important evidence that combining SCD probiotics and TUDCA administration may be more beneficial to behavior.

Kaynakça

  • [1] J. F. Cryan and T. G. Dinan, “Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour,” Nat. Rev. Neurosci., vol. 13, no. 10, pp. 701–712, 2012.
  • [2] C. R. Martin and E. A. Mayer, “Gut-brain axis and behavior,” Nestle Nutr. Inst. Workshop Ser., vol. 88, pp. 45–53, 2017.
  • [3] G. Stavrou and K. Kotzampassi, “Gut microbiome, surgical complications and probiotics,” Ann. Gastroenterol., vol. 30, no. 1, pp. 45–53, 2017.
  • [4] R. George Kerry, J. K. Patra, S. Gouda, Y. Park, H.-S. Shin, and G. Das, “Benefaction of probiotics for human health: A review,” J. Food Drug Anal., vol. 26, no. 3, pp. 927–939, 2018.
  • [5] K. M. Maslowski and C. R. Mackay, “Diet, gut microbiota and immune responses,” Nat. Immunol., vol. 12, no. 1, pp. 5–9, 2011.
  • [6] Z. Song et al., “Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome,” Microbiome, vol. 7, no. 1, p. 9, 2019.
  • [7] P. Gérard, “Metabolism of cholesterol and bile acids by the gut Microbiota,” Pathogens, vol. 3, no. 1, pp. 14–24, 2013.
  • [8] M. L. Chen, K. Takeda, and M. S. Sundrud, “Emerging roles of bile acids in mucosal immunity and inflammation,” Mucosal Immunol., vol. 12, no. 4, pp. 851–861, 2019.
  • [9] S. L. Long, C. G. M. Gahan, and S. A. Joyce, “Interactions between gut bacteria and bile in health and disease,” Mol. Aspects Med., vol. 56, pp. 54–65, 2017.
  • [10] J. A. Winston and C. M. Theriot, “Diversification of host bile acids by members of the gut microbiota,” Gut Microbes, vol. 11, no. 2, pp. 158–171, 2020.
  • [11] E. A. Franzosa et al., “Gut microbiome structure and metabolic activity in inflammatory bowel disease,” Nat. Microbiol., vol. 4, no. 2, pp. 293–305, 2019.
  • [12] Q. Lu, Z. Jiang, Q. Wang, H. Hu, and G. Zhao, “The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation,” Ann. Hepatol., vol. 23, no. 100289, p. 100289, 2021.
  • [13] X. Wu et al., “Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice,” Int. Immunopharmacol., vol. 72, pp. 166–175, 2019.
  • [14] M. Song et al., “Tauroursodeoxycholic acid (TUDCA) improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets,” J. Anim. Sci. Biotechnol., vol. 13, no. 1, p. 73, 2022.
  • [15] X. Zheng, S. Wang, and W. Jia, “Calorie restriction and its impact on gut microbial composition and global metabolism,” Front. Med., vol. 12, no. 6, pp. 634–644, 2018.
  • [16] T. Ceylani, E. Jakubowska-Doğru, R. Gurbanov, H. T. Teker, and A. G. Gozen, “The effects of repeated antibiotic administration to juvenile BALB/c mice on the microbiota status and animal behavior at the adult age,” Heliyon, vol. 4, no. 6, p. e00644, 2018.
  • [17] J. M. Castellano, “Blood-based therapies to combat aging,” Gerontology, vol. 65, no. 1, pp. 84–89, 2019.
  • [18] E. D. Nolte, K. A. Nolte, and S. S. Yan, “Anxiety and task performance changes in an aging mouse model,” Biochem. Biophys. Res. Commun., vol. 514, no. 1, pp. 246–251, 2019.
  • [19] C.-S. Kim et al., “Probiotic supplementation improves cognitive function and mood with changes in gut Microbiota in community-dwelling older adults: A randomized, double-blind, placebo-controlled, multicenter trial,” J. Gerontol. A Biol. Sci. Med. Sci., vol. 76, no. 1, pp. 32–40, 2021.
  • [20] P. Sengupta, “The laboratory rat: Relating its age with human’s,” Int. J. Prev. Med., vol. 4, no. 6, pp. 624–630, 2013.
  • [21] A. A. Walf and C. A. Frye, “The use of the elevated plus maze as an assay of anxiety-related behavior in rodents,” Nat. Protoc., vol. 2, no. 2, pp. 322–328, 2007.
  • [22] M. Komada, K. Takao, and T. Miyakawa, “Elevated plus maze for mice,” J. Vis. Exp., no. 22, 2008.
  • [23] T. Eom, Y. S. Kim, C. H. Choi, M. J. Sadowsky, and T. Unno, “Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease,” J. Microbiol., vol. 56, no. 3, pp. 189–198, 2018.
  • [24] Z. Chen et al., “Bacillus subtilis promotes the release of 5-HT to regulate intestinal peristalsis in STC mice via bile acid and its receptor TGR5 pathway,” Dig. Dis. Sci., vol. 67, no. 9, pp. 4410–4421, 2022.
  • [25] K. Leung and S. Thuret, “Gut Microbiota: A modulator of brain plasticity and cognitive function in ageing,” Healthcare (Basel), vol. 3, no. 4, pp. 898–916, 2015.
  • [26] Y.-W. Liu et al., “Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice,” Brain Res., vol. 1631, pp. 1–12, 2016.
  • [27] A. V. Rao et al., “A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome,” Gut Pathog., vol. 1, no. 1, p. 6, 2009.
  • [28] T. Wang et al., “Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats,” Benef. Microbes, vol. 6, no. 5, pp. 707–717, 2015.
Yıl 2023, , 242 - 246, 22.03.2023
https://doi.org/10.17798/bitlisfen.1231238

Öz

Kaynakça

  • [1] J. F. Cryan and T. G. Dinan, “Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour,” Nat. Rev. Neurosci., vol. 13, no. 10, pp. 701–712, 2012.
  • [2] C. R. Martin and E. A. Mayer, “Gut-brain axis and behavior,” Nestle Nutr. Inst. Workshop Ser., vol. 88, pp. 45–53, 2017.
  • [3] G. Stavrou and K. Kotzampassi, “Gut microbiome, surgical complications and probiotics,” Ann. Gastroenterol., vol. 30, no. 1, pp. 45–53, 2017.
  • [4] R. George Kerry, J. K. Patra, S. Gouda, Y. Park, H.-S. Shin, and G. Das, “Benefaction of probiotics for human health: A review,” J. Food Drug Anal., vol. 26, no. 3, pp. 927–939, 2018.
  • [5] K. M. Maslowski and C. R. Mackay, “Diet, gut microbiota and immune responses,” Nat. Immunol., vol. 12, no. 1, pp. 5–9, 2011.
  • [6] Z. Song et al., “Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome,” Microbiome, vol. 7, no. 1, p. 9, 2019.
  • [7] P. Gérard, “Metabolism of cholesterol and bile acids by the gut Microbiota,” Pathogens, vol. 3, no. 1, pp. 14–24, 2013.
  • [8] M. L. Chen, K. Takeda, and M. S. Sundrud, “Emerging roles of bile acids in mucosal immunity and inflammation,” Mucosal Immunol., vol. 12, no. 4, pp. 851–861, 2019.
  • [9] S. L. Long, C. G. M. Gahan, and S. A. Joyce, “Interactions between gut bacteria and bile in health and disease,” Mol. Aspects Med., vol. 56, pp. 54–65, 2017.
  • [10] J. A. Winston and C. M. Theriot, “Diversification of host bile acids by members of the gut microbiota,” Gut Microbes, vol. 11, no. 2, pp. 158–171, 2020.
  • [11] E. A. Franzosa et al., “Gut microbiome structure and metabolic activity in inflammatory bowel disease,” Nat. Microbiol., vol. 4, no. 2, pp. 293–305, 2019.
  • [12] Q. Lu, Z. Jiang, Q. Wang, H. Hu, and G. Zhao, “The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation,” Ann. Hepatol., vol. 23, no. 100289, p. 100289, 2021.
  • [13] X. Wu et al., “Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice,” Int. Immunopharmacol., vol. 72, pp. 166–175, 2019.
  • [14] M. Song et al., “Tauroursodeoxycholic acid (TUDCA) improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets,” J. Anim. Sci. Biotechnol., vol. 13, no. 1, p. 73, 2022.
  • [15] X. Zheng, S. Wang, and W. Jia, “Calorie restriction and its impact on gut microbial composition and global metabolism,” Front. Med., vol. 12, no. 6, pp. 634–644, 2018.
  • [16] T. Ceylani, E. Jakubowska-Doğru, R. Gurbanov, H. T. Teker, and A. G. Gozen, “The effects of repeated antibiotic administration to juvenile BALB/c mice on the microbiota status and animal behavior at the adult age,” Heliyon, vol. 4, no. 6, p. e00644, 2018.
  • [17] J. M. Castellano, “Blood-based therapies to combat aging,” Gerontology, vol. 65, no. 1, pp. 84–89, 2019.
  • [18] E. D. Nolte, K. A. Nolte, and S. S. Yan, “Anxiety and task performance changes in an aging mouse model,” Biochem. Biophys. Res. Commun., vol. 514, no. 1, pp. 246–251, 2019.
  • [19] C.-S. Kim et al., “Probiotic supplementation improves cognitive function and mood with changes in gut Microbiota in community-dwelling older adults: A randomized, double-blind, placebo-controlled, multicenter trial,” J. Gerontol. A Biol. Sci. Med. Sci., vol. 76, no. 1, pp. 32–40, 2021.
  • [20] P. Sengupta, “The laboratory rat: Relating its age with human’s,” Int. J. Prev. Med., vol. 4, no. 6, pp. 624–630, 2013.
  • [21] A. A. Walf and C. A. Frye, “The use of the elevated plus maze as an assay of anxiety-related behavior in rodents,” Nat. Protoc., vol. 2, no. 2, pp. 322–328, 2007.
  • [22] M. Komada, K. Takao, and T. Miyakawa, “Elevated plus maze for mice,” J. Vis. Exp., no. 22, 2008.
  • [23] T. Eom, Y. S. Kim, C. H. Choi, M. J. Sadowsky, and T. Unno, “Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease,” J. Microbiol., vol. 56, no. 3, pp. 189–198, 2018.
  • [24] Z. Chen et al., “Bacillus subtilis promotes the release of 5-HT to regulate intestinal peristalsis in STC mice via bile acid and its receptor TGR5 pathway,” Dig. Dis. Sci., vol. 67, no. 9, pp. 4410–4421, 2022.
  • [25] K. Leung and S. Thuret, “Gut Microbiota: A modulator of brain plasticity and cognitive function in ageing,” Healthcare (Basel), vol. 3, no. 4, pp. 898–916, 2015.
  • [26] Y.-W. Liu et al., “Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice,” Brain Res., vol. 1631, pp. 1–12, 2016.
  • [27] A. V. Rao et al., “A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome,” Gut Pathog., vol. 1, no. 1, p. 6, 2009.
  • [28] T. Wang et al., “Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats,” Benef. Microbes, vol. 6, no. 5, pp. 707–717, 2015.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Taha Ceylani 0000-0002-3041-6010

Hikmet Taner Teker 0000-0002-6621-3071

Yayımlanma Tarihi 22 Mart 2023
Gönderilme Tarihi 8 Ocak 2023
Kabul Tarihi 3 Mart 2023
Yayımlandığı Sayı Yıl 2023

Kaynak Göster

IEEE T. Ceylani ve H. T. Teker, “The Combined Use of SCD Probiotics and Tauroursodeoksikolik Asit (TUDCA) is More Effective in Controlling Anxiety-Like Behavior in Aged Rats”, Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, c. 12, sy. 1, ss. 242–246, 2023, doi: 10.17798/bitlisfen.1231238.



Bitlis Eren Üniversitesi
Fen Bilimleri Dergisi Editörlüğü

Bitlis Eren Üniversitesi Lisansüstü Eğitim Enstitüsü        
Beş Minare Mah. Ahmet Eren Bulvarı, Merkez Kampüs, 13000 BİTLİS        
E-posta: fbe@beu.edu.tr