Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae

Mehmet Fidan

doi:10.17798/bitlisfen.1674538

Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae

Abstract

This study investigated the protective effects of Taraxacum officinale leaf extract against hydrogen peroxide-induced oxidative stress in Drosophila melanogaster larvae. T. officinale leaves collected from the Çorum-Amasya region were dried and extracted with ethanol. Synchronized third instar D. melanogaster larvae were divided into six groups: control group, oxidative stress group, three test groups with different extract concentrations (1%, 2%, 4%), and a positive control group (ascorbic acid). Larval mortality was monitored at 24, 48, and 72 hours, and antioxidant enzyme activities (SOD, CAT, GPx) were measured at 48 hours. Results showed that mortality rates significantly increased in the oxidative stress group compared to the control group, while mortality decreased in a dose-dependent manner in the extract-treated groups. Biochemical analyses revealed that antioxidant enzyme activities were significantly elevated in the extract-treated groups compared to the stress group. The highest activity increase was observed in the group treated with 4% extract. These findings demonstrate that T. officinale extract has protective effects against oxidative stress in D. melanogaster larvae and strengthens the antioxidant defense system in a dose-dependent manner.

Keywords

References

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Details

Primary Language

English

Subjects

Genotoxicity and Cytotoxicity, Genetics (Other)

Journal Section

Research Article

Authors

Mehmet Fidan ^*
0000-0001-9016-6730
Türkiye

Publication Date

December 31, 2025

Submission Date

April 11, 2025

Acceptance Date

October 14, 2025

Published in Issue

Year 2025 Volume: 14 Number: 4

DOI

https://doi.org/10.17798/bitlisfen.1674538

IZ

https://izlik.org/JA98ST83CN

Cite

RIS / Bibtex

APA

Fidan, M. (2025). Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 14(4), 2032-2051. https://doi.org/10.17798/bitlisfen.1674538

AMA

1.Fidan M. Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2025;14(4):2032-2051. doi:10.17798/bitlisfen.1674538

Chicago

Fidan, Mehmet. 2025. “Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae”. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi 14 (4): 2032-51. https://doi.org/10.17798/bitlisfen.1674538.

EndNote

Fidan M (December 1, 2025) Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi 14 4 2032–2051.

IEEE

[1]M. Fidan, “Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae”, Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, vol. 14, no. 4, pp. 2032–2051, Dec. 2025, doi: 10.17798/bitlisfen.1674538.

ISNAD

Fidan, Mehmet. “Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae”. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi 14/4 (December 1, 2025): 2032-2051. https://doi.org/10.17798/bitlisfen.1674538.

JAMA

1.Fidan M. Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2025;14:2032–2051.

MLA

Fidan, Mehmet. “Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae”. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, vol. 14, no. 4, Dec. 2025, pp. 2032-51, doi:10.17798/bitlisfen.1674538.

Vancouver

1.Mehmet Fidan. Protective Effects of Taraxacum Officinale Leaf Extract Against Hydrogen Peroxide-Induced Oxidative Stress in Drosophila Melanogaster Larvae. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2025 Dec. 1;14(4):2032-51. doi:10.17798/bitlisfen.1674538

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