Sülfodiazin, Sülfomerazin ve Sülfometazinin İyonlaşma Sabitlerinin Potansiyometrik Titrasyon Yöntemi ile Tayini

Yıl 2020, Cilt: 9 Sayı: 3, 1071 - 1079, 26.09.2020

Dilara Dereli , Abbase Güleren Alsancak

https://doi.org/10.17798/bitlisfen.664126

Öz

Bu çalışmada sülfonamit grubu ilaçlardan sülfodiazin, sülfomerazin ve sülfometazinin biyolojik sıvılardaki çözünürlük, lipofilisite, asitlik, transfer davranışı, reseptörlere bağlanma ve geçirgenlik gibi özellikleri hakkında kritik bilgiler elde etmemizi sağlayan iyonlaşma sabiti değerleri potansiyometrik titrasyon yöntemiyle tayin edilmiştir. Bileşiklerin suda çözünürlükleri az olması sebebiyle belirli yüzdelerde metanol-su (v/v) ikili karışımlarında 25oC’de çalışılmış ve verilerin değerlendirilmesinde PKPOT programı ile Gran metodu kullanılmıştır. Metanol-su ortamında hesaplanan iyonlaşma sabiti değerlerinden sudaki iyonlaşma sabiti değerlerine geçişte Yasuda- Shedlovsky ekstrapolasyon yöntemi kullanılmıştır. Sülfodiazin için iyonlaşma sabiti değerleri 2,915-6,936; sülfomerazin için 2,734-6,955; sülfometazin için ise 2,466-7,537 olarak bulunmuştur. İyonlaşma sabitlerinin potansiyometrik titrasyon yöntemiyle tayininden elde edilen veriler bu ilaç aktif bileşiklerle çalışan araştırmacılara bilgi kaynağı oluşturacaktır.

Anahtar Kelimeler

Sülfonamit, İyonlaşma sabiti, potansiyometrik titrasyon

Destekleyen Kurum

Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri Yönetim Birimi

Proje Numarası

YL-1060

Teşekkür

Bu çalışma Yüksek Lisans Tez Projesi olarak, Bilimsel Araştırma Projeleri Yönetim Birimi tarafından YL-1060 numaralı proje olarak desteklenmiştir. Süleyman Demirel Üniversitesi Araştırma Projeleri Yönetim birimine teşekkür ederim.

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