The Combined Use of SCD Probiotics and Tauroursodeoksikolik Asit (TUDCA) is More Effective in Controlling Anxiety-Like Behavior in Aged Rats
Yıl 2023,
Cilt: 12 Sayı: 1, 242 - 246, 22.03.2023
Taha Ceylani
Hikmet Taner Teker
Öz
In this study, the effects of TUDCA administration with a SCD probiotics for one week on locomotors activity and anxious behavior were investigated. Male Saprague-Dawley rats aged 24 months were used as the model organism. At the end of the application, open-field and elevated plus maze behavioral tests were performed on the rats. Although SCD probiotics were more effective on anxious behavior, the group in which they were administered together had a significantly greater effect on locomotor activity and anxious behavior. This study provides important evidence that combining SCD probiotics and TUDCA administration may be more beneficial to behavior.
Kaynakça
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Yıl 2023,
Cilt: 12 Sayı: 1, 242 - 246, 22.03.2023
Taha Ceylani
Hikmet Taner Teker
Kaynakça
- [1] J. F. Cryan and T. G. Dinan, “Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour,” Nat. Rev. Neurosci., vol. 13, no. 10, pp. 701–712, 2012.
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- [6] Z. Song et al., “Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome,” Microbiome, vol. 7, no. 1, p. 9, 2019.
- [7] P. Gérard, “Metabolism of cholesterol and bile acids by the gut Microbiota,” Pathogens, vol. 3, no. 1, pp. 14–24, 2013.
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- [9] S. L. Long, C. G. M. Gahan, and S. A. Joyce, “Interactions between gut bacteria and bile in health and disease,” Mol. Aspects Med., vol. 56, pp. 54–65, 2017.
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- [11] E. A. Franzosa et al., “Gut microbiome structure and metabolic activity in inflammatory bowel disease,” Nat. Microbiol., vol. 4, no. 2, pp. 293–305, 2019.
- [12] Q. Lu, Z. Jiang, Q. Wang, H. Hu, and G. Zhao, “The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation,” Ann. Hepatol., vol. 23, no. 100289, p. 100289, 2021.
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