LİPÖDEMDE SUBKÜTAN YAĞ DOKUSU KALINLIĞI İLE ADİPOKİNLER ARASINDAKİ İLİŞKİ

Öz

Giriş ve Amaç: Adipokinler ve disfonksiyonel yağ dokusu arasındaki ilişkide subkutan yağ dokusundan ziyade viseral yağ dokusundaki değişikliklerin rolüne dikkat çekilmiştir. Özellikle cilt altı yağ dokusunun etkilendiği lipödemde adipokinler hakkında bilgi yetersizdir. Bu çalışmada lipödemli hastalarda adiponektin, ghrelin, resistin ve visfatin düzeylerinin ve bunların yağ doku kalınlığı ile ilişkisinin araştırılması amaçlandı. Bu amaçla cilt altı yağ dokusu kalınlığı ultrasonografi ile objektif olarak değerlendirildi. Gereç ve Yöntemler: Lipödem tanısı almış toplam 19 kadın hasta ve yaş farkı olmayan 15 sağlıklı kadın çalışmaya dahil edildi. Deri ve deri altı yağ dokusu kalınlıkları ultrasonografik olarak ölçüldü. Tüm deneklerin serum adiponektin, ghrein, resistin ve visfatin seviyeleri sandviç ELISA protokolü kullanılarak ölçüldü. Bulgular: Lipödemli hastalarda, uyluk ve baldırda subkutan subkutan doku kalınlığı ve toplam deri-subkutan kalınlığı kontrollere kıyasla, uyluktaki deri kalınlığı dışında önemli ölçüde arttı (P<0.000). Lipödemli hastalar ve kontroller arasında adiponektin, ghrelin, resistin ve visfatin serum seviyelerinde anlamlı fark yoktu (P>0.05). Lipödemli hastalarda ve kontrollerde ultrason ile adiponektin, ghrelin, resistin ve visfatin ile deri, deri altı ve toplam kalınlık ölçümleri arasında anlamlı bir ilişki bulunmadı (P>0.05). İstatistiksel olarak anlamlı olmasa da detaylı incelendiğinde adipokinler ve ultrason ölçümleri arasındaki ilişkide gruplar arasında pozitif veya negatif korelasyonlar gözlendi. Sonuç: Bulgularımıza göre, serum adipokin düzeyleri ile deri altı yağ dokusu kalınlığı arasında anlamlı bir ilişki bulunmamakla birlikte, tamamen ilgisiz oldukları tartışmalıdır. Daha geniş serilerde yapılacak çalışmalar adipokinlerin cilt altı doku kalınlığı ile ilişkisine ve ultrasonografinin önemine ışık tutacaktır.

Anahtar Kelimeler

• Lipödem
• Adipokin
• Resistin

THE RELATIONSHIP BETWEEN ADIPOKINES AND THE THICKNESS OF SUBCUTANEOUS ADIPOSE TISSUE IN LIPEDEMA

Öz

Objective: Attention has been drawn to the role of visceral adipose tissue changes rather than subcutaneous adipose tissue the relationship between adipokines and dysfunctional adipose tissue. Especially in lipedema in which subcutaneous adipose tissue is affected, the information on adipokines is insufficient. In this study, it aimed to investigate the levels of adiponectin, ghrelin, resistin and visfatin and their relationship with adipose tissue thickness in patients with lipedema. For this purpose, the thickness of the subcutaneous adipose tissue was objectively evaluated by ultrasound. Materials and Methods: A total of 19 female patients diagnosed with lipedema and 15 healthy women with no age difference were included in the study. The thickness of the skin and subcutaneous adipose tissue was measured by ultrasound. The serum levels of adiponectin, ghrein, resistin and visfatin of all subjects were measured using the sandwich ELISA protocol. Results: In patients with lipedema, the thickness subcutaneous tissue and thickness of total skin-subcutaneous were significantly increased at skin the thigh and calf, excluding skin thickness in the thigh, compared to controls (P<0.000). There was no significant difference in serum levels of adiponectin, ghrelin, resistin and visfatin between patients with lipedema and controls (P>0.05). No significant correlation was found between adiponectin, ghrelin, resistin and visfatin and subcutaneous and total thickness measurements by ultrasound in patients with lipedema and controls (P>0.05). Although not statistically significant, when examined as positive or negative correlations were observed between the groups in the relationship between adipokines and ultrasound. Conclusion: According to our findings, although no significant relationship was found between serum levels of adipokines and subcutaneous adipose tissue thickness, it is controversial that they are completely unrelated. Further studies in larger series will shed light on the relationship between adipokines and subcutaneous tissue thickness and the importance of ultrasonography.

Anahtar Kelimeler

• Adiponectin
• Lipodemea
• Resistin

Kaynakça

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