New Class of Small Non-coding RNAs: tiRNA

Öz

Small non-coding RNAs are gaining more and more importance in cancer development, diagnosis and treatment because of their functions. During cellular stress, tiRNA structures are formed by angiogenin-mediated cleavage of mature tRNA.tiRNAs are classified as 3' and 5' tiRNAs depending on whether they contain the anticodon cleavage site.tRNAs contribute to the cell stress response and play an active role in the development of various human diseases, especially cancer. Exploring new approaches with in-depth study of tiRNA functions and targeting potential therapeutic biomarkers are envisaged.It is predicted that this new class of small non-coding RNA may provide new therapeutic targets to treat cancer in its classification, biogenesis and biological role.

Anahtar Kelimeler

• Non-coding RNA
• tRNA
• tiRNA
• Angiogenin

Yeni Küçük Kodlamayan RNA Sınıfı: tiRNA

Öz

Küçük kodlamayan RNA'lar, kanser gelişimi, tanı ve tedavisinde, işlevleri nedeniyle her geçen gün daha da önem kazanmaktadır. Hücresel stres sırasında anjiyogenin aracılı olgun tRNA’nın ayrılması ile tiRNA yapıları meydana gelmektedir. tiRNA'lar antikodon kesim bölgesini barındırıp barındırmadığına bağlı olarak 3' ve 5' tiRNA'lar olarak sınıflandırılmaktadır. tRNAlar hücre stres yanıtına katkıda bulunmakta ve başta kanser olmak üzere çeşitli insan hastalıklarının gelişiminde etkin roller oynamaktadır. tiRNA fonksiyonlarının derinlemesine çalışılması ile yeni yaklaşımların keşfedilmesi ve potansiyel terapotik biyobelirteçlerin hedeflenmesi öngörülmektedir. Bu yeni küçük kodlamayan RNA sınıfının sınıflandırmasını, biyogenezisini ve biyolojik rolünü kanseri tedavi etmek için yeni terapötik hedefler sağlayabileceği tahmin edilmektedir.

Anahtar Kelimeler

• Kodlanmayan RNA
• tRNA
• tiRNA
• Anjiyogenin

Kaynakça

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