COVID-19’lu Hastalar İçin Mezenkimal Kök Hücre Tedavisi

Abstract

Yeni koronavirüs (SARS-CoV-2) enfeksiyonunun neden olduğu COVID-19, Dünya Sağlık Örgütü (WHO) tarafından uluslararası bir halk sağlığı acil durumu olarak belirtilmiştir ve felaket derecesi küresel "pandemi" olarak tanımlanmıştır. COVID-19 tipik olarak ateş ve solunum semptomları ile ilişkilidir. Genellikle ciddi solunum sıkıntısı ve yüksek mortalite oranı taşıyan çoklu organ yetmezliği gelişir. inflamasyon, pulmoner ödem ve aşırı reaktif bir immun tepki hipoksiye, Acute respiratory distress sendromu (ARDS) ve akciğer hasarına yol açabilir. Mezenkimal kök hücreler (MKH'ler) güçlü ve geniş kapsamlı immünomodülatör aktivitelere sahiptir. Çalışmalar, MKH'nin akciğer hasarını önleme, iltihabı azaltma, immun tepkileri azaltma ve alveolar sıvı temizlenmesine yardımcı olduğunu gösterdi. Ayrıca, MKH'ler antimikrobiyal ve ağrıyı azaltan moleküller üretir. İntravenöz yoldan uygulandığında, hücreler doğrudan çoğunlukla sekestrasyon olan akciğerlere gider, bu da akciğer hastalığının tedavisi için büyük bir fayda sağlar. Bu derlemede, MKH kullanarak, hastanın COVID-19'a karşı immünolojik yanıtlarını iyileştirmek için bu yeni yaklaşımı dikkate aldık ve önerilen bu tedavinin yönlerini tartıştık. Şu anda COVID-19 hastalarının tedavisi için onaylanmış MKH temelli yaklaşımlar yoktur, fakat klinik çalışmalar devam etmektedir.

Keywords

• COVID-19
• koronavirüs
• SARS-CoV-2
• Mezenkimal kök hücreler

Mesenchymal Stem Cell Treatment for Patients with COVID-19

Abstract

The COVID-19, caused by the new type of coronavirus (SARS-CoV-2) infection that emerged in Wuhan, China in late 2019, has been registered as a public health emergency of international by the World Health Organization (WHO), and its harm degree is defined as a global “pandemic”. COVID-19 is typically associated with fever and respiratory symptoms. It usually develops severe respiratory distress and multi-organ failure which carry a high mortality rate. Inflammation, pulmonary edema and an over-reactive immune response can give rise to hypoxia, Acute respiratory distress syndrome (ARDS) and lung damage. Mesenchymal stem cells (MSCs) possess activities potent and extensive immunomodulatory and anti-inflammatory. Studies have demonstrated the MSC’s impressive capacity to inhibit lung damage, reduce inflammation, dampen immune responses and aid with alveolar fluid clearance. MSCs have antiviral properties and have been used in the treatment of various viral infections in the last years. Systemic damage caused by cytokine storm that occurs due to the overreaction of the immune system in patients with COVID-19 has been shown to be very important. Therefore, it was thought that MSCs could suppress overactivated immune systems of patients with COVID-19 and be effective in the treatment of the disease. Mesenchymal stem cells (MSCs) with strong immunomodulatory properties have been used for treatment and positive results have been obtained. In this rewiev, we considered this new approach to improve patient’s immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment.

Keywords

• COVID-19
• Coronavirus
• SARS-CoV-2
• mesenchymal stem cells

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