The Relationship Between Blood Lipid Parameters and Development of Intracerebral Hemorrhage in Ischemic Stroke Patients

Abstract

Objective: The aim of this study was to investigate the relationship between the development of hemorrhagic transformation (HT) and blood lipid parameters in patients with ischemic stroke. Material and Methods: For the study, patients with acute ischemic stroke who received inpatient treatment in the neurology clinic between 2015-2020 were evaluated retrospectively. The patients were divided into 2 groups as patients with and without hemorrhagic transformation in ischemic tissue. The lipid profile of the patients (triglyceride, total cholesterol, LDL cholesterol and HDL cholesterol) was evaluated with blood samples taken between 5:00 and 7:00 hours after 12 hours of fasting. Results: In the study, 100 patients who developed HT in ischemic tissue (40) and did not develop HT (60) were included. There was no difference between the groups in terms of DM (p: 0.229) and hypertension (p: 0.698). While there was no significant difference between the groups in terms of triglycerides (p: 0.266) and HDL (p: 0.718), the levels of total cholesterol (p: 0.017) and LDL cholesterol (p: 0.015) were higher in the patient group who developed HT compared to the non-developed patient group, and the difference was significant. Conclusion In our study, no relationship was observed between blood lipid parameters and prognosis. However, we found that LDL cholesterol and total cholesterol levels were significantly higher in stroke patients with hemorrhagic transformation compared to ischemic stroke patients without hemorrhagic transformation. However, to determine whether this has had a clinically significant effect, our findings need to be confirmed by expanding the sample size.

Keywords

• Hemorrhagic transformation
• ischemic stroke
• lipids
• risk factors

İskemik İnme Hastalarında Kan Lipid Parametreleri ve İntraserebral Hemoraji Gelişimi Arasındaki İlişki

Abstract

Giriş ve Amaç: Çalışmada iskemik inme hastalarında hemorajik transformasyon (HT) gelişimi ile kan lipid parametrelerinin ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışma için 2015-2020 yılları arasında nöroloji kliniğinde yatarak tedavi alan akut iskemik inme hastaları retrospektif olarak değerlendirildi. Hastalar iskemik dokuda hemorajik transformasyon olan ve olmayan hastalar olarak 2 gruba ayrıldı. Hastaların lipid profili (trigliserid, total kolesterol, LDL kolesterol ve HDL kolesterol) 12 saat açlık sonrası, saat 5:00-07:00 arası alınan kan örnekleri ile değerlendirildi. Bulgular: Çalışmada iskemik dokuda HT gelişen (40) ve HT gelişmeyen (60) 100 hasta dahil edildi. Gruplar arasında DM (p: 0.229) ve hipertansiyon (p: 0.698) açısından farklılık yoktu. Gruplar arasında trigliserit (p: 0.266) ve HDL (p: 0.718) açısından anlamlı fark yokken, HT gelişen hasta gurubunda total kolesterol (p: 0.017) ve LDL kolesterol (p: 0.015) seviyeleri gelişmeyen hasta gurubuna göre yüksekti ve aradaki fark anlamlıydı. Sonuç: Çalışmamızda kan lipid parametreleri ve prognoz arasında bir ilişki gözlenmedi. Fakat hemorajik transformasyon gelişen inme hastalarında LDL kolesterol ve total kolesterol düzeylerinin hemorajik transformasyon gelişmeyen iskemik inme hastalarına göre anlamlı yüksek olduğunu bulduk. Ancak bunun klinik olarak önemli bir etkiye yol açıp açmadığını belirlemek için bulgularımızın, örneklem büyüklüğünün genişletilerek doğrulanması gerekmektedir.

Keywords

• Hemorajik transformasyon
• iskemik inme
• lipidler
• risk faktörleri

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