The effect of vitamin E supplements added to Clomiphene citrate treatment on fertility in polycystic ovary syndrome

Abstract

Objective: This study was designed to investigate the role of vitamin E supplementation during cycles in ovulation induction with clomiphene citrate (CC) in women with infertile Polycystic Ovary Syndrome (PCOS) on ovulation defect, endometrium thickness, clinical and ongoing pregnancy increase. Materials and Methods: In this retrospective case control study, PCOS patients admitting to Yenibosna Private Nisa Hospital Obstetrics Clinic between January 1st 2015 and October 1st 2020 for infertility treatment were evaluated. A total of 306 patients were evaluated, including 139 Patients with PCOS receiving CC and vitamin E treatment (Vitamin E group), and 167 patients with PCOS who received CC treatment only (Clomiphene group). The primary result was that the cumulative ovulation rate (i.e. the rate of the cycles in which ovulation occurs during the entire follow-up period), the secondary result was the number of dominant follicles, the endometrial thickness on the day of HCG admission, and the clinical and ongoing pregnancy rates. Results: No statistical differences were detected between the two groups in terms of dominant follicle counts, ovulation rates, and clinical and ongoing pregnancy rates (p>0.05). When the vitamin E group and control group were compared it was determined that there was a statistically significant difference between the groups in terms of endometrial thickness (p<0.000). Conclusion: It was found that vitamin E supplementation given during the cycles was not effective in increasing the number of dominant follicles, ovulation rates, and clinical and ongoing pregnancy rates in infertile women with PCOS, but increased endometrial thickness.

Keywords

• Vitamin E
• infertility
• polycystic ovary syndrome
• clomiphene citrate

Polikistik over sendromunda Clomiphene sitrat tedavisine eklenen E vitamini takviyelerinin fertilite üzerine etkisi

Öz

Giriş ve Amaç: Bu çalışma, infertil Polikistik Over Sendromu (PKOS) olan kadınlarda klomifen sitrat (KS) ile ovulasyon indüksiyonunda sikluslar sırasında E vitamini desteğinin ovülasyon defekti, endometrium kalınlığı, klinik ve devam eden gebelik artışı üzerindeki rolünü araştırmak için tasarlanmıştır. Gereç ve Yöntemler: Bu retrospektif vaka kontrol çalışmasında, 1 Ocak 2015 ile 1 Ekim 2020 tarihleri arasında Yenibosna Özel Nisa Hastanesi Kadın Hastalıkları Kliniğine infertilite tedavisi için başvuran PKOS hastaları değerlendirildi. KS ve vitamin E tedavisi alan (Vitamin E grubu) PKOS'lu 139 hasta ve sadece KS tedavisi alan 167 PKOS hastası (Kontrol grubu) olmak üzere toplam 306 hasta değerlendirildi. Birincil sonuç, kümülatif yumurtlama oranının (yani, tüm takip süresi boyunca yumurtlamanın meydana geldiği döngülerin oranı), ikincil sonucun dominant folikül sayısı, HCG'ye uygulama gününde endometriyal kalınlık ve klinik ve devam eden gebelik oranlarıdır. Bulgular: İki grup arasında dominant folikül sayıları, ovulasyon oranları, klinik ve devam eden gebelik oranları açısından istatistiksel fark saptanmadı (p>0.05). E vitamini grubu ile kontrol grubu karşılaştırıldığında endometrial kalınlık açısından gruplar arasında istatistiksel olarak anlamlı fark olduğu belirlendi (p <0.000). Sonuç: Sikluslar sırasında verilen E vitamini desteğinin PKOS'lu infertil kadınlarda dominant folikül sayısını, ovulasyon oranlarını ve klinik ve devam eden gebelik oranlarını artırmada etkili olmadığı, ancak endometrial kalınlık artışına neden olduğu bulundu.

Anahtar Kelimeler

• E vitamin
• kısırlık
• polikistik over sendromu
• klomifen sitrat

Kaynakça

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