Orbital Socket Infection Associated with Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum pigrum
Abstract
Purpose: To present a rare case of socket infection associated with hydroxyapatite sphere exposure in which Dolosigranulum pigrum (D. pigrum) was isolated, and to review the relevant literature regarding its ocular pathogenicity.
Methods: A retrospective case analysis was conducted, including clinical presentation, microbiological findings, surgical management, and treatment outcomes of a patient with recurrent socket infection. Relevant literature on ocular infections caused by D. pigrum was reviewed to contextualize the clinical significance of this organism.
Results: A 45 year-old immunocompetent male with a history of enucleation and orbital implantplacement developed recurrent mucopurulent socket infection. Initial cultures revealed Staphylococcus aureus, Staphylococcus epidermidis, and Schaalia odontolytica. Following implant removal and antibiotic therapy, infection recurred, and repeat cultures isolated Dolosigranulum pigrum along with S. aureus. The D. pigrum isolate was susceptible to penicillin, vancomycin, and meropenem, and resistant to clindamycin. Complete clinical resolution was achieved with topical moxifloxacin.
Conclusion: Dolosigranulum pigrum is an uncommon but clinically relevant ocular pathogen. This case highlights that, beyond immunosuppressed individuals, D. pigrum may also cause infection in immunocompetent patients when local predisposing factors—such as chronic implant exposure—are present. Accurate diagnosis and targeted therapy are essential for successful management.
Keywords
References
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Details
Primary Language
English
Subjects
Ophthalmology
Journal Section
Review
Publication Date
December 31, 2025
Submission Date
December 17, 2025
Acceptance Date
December 24, 2025
Published in Issue
Year 2025 Volume: 7
APA
Özmen, S., Talyurt, İ., & Helvacıoğlu Özmen, N. (2025). Orbital Socket Infection Associated with Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum pigrum. Clinical and Experimental Ocular Trauma and Infection, 7, 13-18. https://izlik.org/JA24FY79LK
AMA
1.Özmen S, Talyurt İ, Helvacıoğlu Özmen N. Orbital Socket Infection Associated with Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum pigrum. CEOTI. 2025;7:13-18. https://izlik.org/JA24FY79LK
Chicago
Özmen, Semih, İbrahim Talyurt, and Nil Helvacıoğlu Özmen. 2025. “Orbital Socket Infection Associated With Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum Pigrum”. Clinical and Experimental Ocular Trauma and Infection 7 (December): 13-18. https://izlik.org/JA24FY79LK.
EndNote
Özmen S, Talyurt İ, Helvacıoğlu Özmen N (December 1, 2025) Orbital Socket Infection Associated with Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum pigrum. Clinical and Experimental Ocular Trauma and Infection 7 13–18.
IEEE
[1]S. Özmen, İ. Talyurt, and N. Helvacıoğlu Özmen, “Orbital Socket Infection Associated with Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum pigrum”, CEOTI, vol. 7, pp. 13–18, Dec. 2025, [Online]. Available: https://izlik.org/JA24FY79LK
ISNAD
Özmen, Semih - Talyurt, İbrahim - Helvacıoğlu Özmen, Nil. “Orbital Socket Infection Associated With Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum Pigrum”. Clinical and Experimental Ocular Trauma and Infection 7 (December 1, 2025): 13-18. https://izlik.org/JA24FY79LK.
JAMA
1.Özmen S, Talyurt İ, Helvacıoğlu Özmen N. Orbital Socket Infection Associated with Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum pigrum. CEOTI. 2025;7:13–18.
MLA
Özmen, Semih, et al. “Orbital Socket Infection Associated With Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum Pigrum”. Clinical and Experimental Ocular Trauma and Infection, vol. 7, Dec. 2025, pp. 13-18, https://izlik.org/JA24FY79LK.
Vancouver
1.Semih Özmen, İbrahim Talyurt, Nil Helvacıoğlu Özmen. Orbital Socket Infection Associated with Hydroxyapatite Implant Exposure: Isolation of Dolosigranulum pigrum. CEOTI [Internet]. 2025 Dec. 1;7:13-8. Available from: https://izlik.org/JA24FY79LK