Investigation of the Electrochemical Behavior of Epinephrine with Polycatechol/SiO₂NP Modified Electrodes

Year 2025, Volume: 4 Issue: 1, 16 - 25, 31.12.2025

Merve Yılmaz , Melike Bilgi Kamaç , Ayşenur Yılmaz Kabaca , Şahin Toparli , Faruk Terzioğlu , Emir Ateş

Abstract

Epinephrine is an important neurotransmitter that plays a role in many areas of the human body, from the central nervous system to the cardiovascular system. In this study, the electrochemical behavior of epinephrine was investigated on polycatechol/SiO₂NP-modified screen-printed carbon electrodes (SPCE). Polycatechol (PCA) was modified electrochemically, while SiO₂NPs were physically adsorbed. Optimization of the number of cycles was performed for the formation of PCA on the SPCE surface, and optimization of the amount of SiO₂NP modification was performed. The electrochemical behavior of epinephrine on the prepared SPCE/PCA/SiO₂NP electrodes was investigated by cyclic voltammetry. PCA and SiO₂NP exhibited a synergistic effect, increasing the electrode's conductivity and exhibiting an electrocatalytic effect against epinephrine. These findings suggest that the SPCE/PCA/SiO₂NP electrode can be used as an electrochemical sensor for the analysis of epinephrine and similar neurotransmitters.

Keywords

Epinephrine , polycatechol , silicon oxide nanoparticles , electrochemical sensors

Supporting Institution

Scientific and Technological Research Council of Turkey (TÜBİTAK)

Project Number

1919B012332629

Thanks

This work was supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK) under the 2209-A Research Projects Support Program for Undergraduate Students (Project No: 1919B012332629). The author expresses his gratitude for the financial support provided by TÜBİTAK. Merve YILMAZ ÇILÇAR and Ayşenur YILMAZ KABACA would like to thank the Scientific and Technological Research Council of Turkey (TÜBİTAK) for the financial support provided by the BIDEB/2211-A Doctoral Scholarship Programs.

Polikatekol/SiO₂NP Modifiye Elektrotlarla Epinefrinin Elektrokimyasal Davranışının İncelenmesi

Abstract

Epinefrin, insan vücudunda merkezi sinir sisteminden kardiyovasküler sistemlere kadar birçok yer de rol alan önemli bir nörotransmiterdir. Bu çalışmada, polikatekol/SiO₂NP modifiyeli yüzey baskılı karbon elektrotlarda (SPCE) epinefrinin elektrokimyasal davranışı incelenmiştir. Polikatekol (PCA) elektrokimyasal yöntemle, SiO₂NP’ler fiziksel adsorpsiyon ile modifiye edilmiştir. PCA’nın SPCE yüzeyinde oluşturulmasında, döngü sayısı optimizasyonu, SiO₂NP’lerin modifikasyonunda miktar optimizasyonu yapılmıştır. Hazırlanan SPCE/PCA/SiO₂NP elektrotlarda epinefrinin elektrokimyasal davranışı dönüşümlü voltametri ile incelenmiştir. PCA ve SiO₂NP sinerjik bir göstererek elektrodun iletkenliğini artırmış ve epinefrine karşı elektrokatalitik etki göstermiştir. Bu bulgular, SPCE/PCA/SiO₂NP elektrotunun, epinefrin ve benzer yapıdaki nörotransmiterlerin analizinde elektrokimyasal sensör olarak kullanılabileceğini ortaya koymaktadır.

Keywords

Epinefrin , polikatekol , silisyum oksit nanopartiküller , elektrokimyasal sensörler

Supporting Institution

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK)

Project Number

1919B012332629

Thanks

Bu çalışma, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK) tarafından Lisans Öğrencileri için 2209-A Araştırma Projeleri Destekleme Programı (Proje No: 1919B012332629) kapsamında desteklenmiştir. Yazar, TÜBİTAK tarafından sağlanan maddi destek için minnettarlığını sunar. Merve YILMAZ ÇILÇAR ve Ayşenur YILMAZ KABACA, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu'nun (TÜBİTAK) BIDEB/2211-A Doktora Burs Programları kapsamında sağladığı maddi destek için teşekkürlerini sunar.

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