Araştırma Makalesi
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Olanzapin'in İndirgenme Davranışının İncelenmesi ve İlaçlar ile İnsan İdrarında Diferansiyel puls Tekniği ile Tayini

Yıl 2020, Cilt 6, Sayı 2, 342 - 352, 29.12.2020

Öz

Olanzapinin elektrokimyasal indirgenme özelliği DPV (diferansiyel puls voltametri) ve CV (dönüşümlü voltametri) teknikleri ile camsı karbon çalışma elektrodu kullanılarak incelendi. pH’sı 0.50 – 12.05 aralığında değişen farklı tampon çözeltilerde ölçümler alındı. Pik potansiyelinin ve pik akımının pH ile değişimi incelendi ve destek elektrolit olarak pH=7.0 Britton-Robinson tampon çözeltisi seçildi. Elektrot reaksiyonuna katılan elektron ve proton sayısını belirlemek için, artan pH ile pik potansiyellerinin değişimi incelendi. Transfer edilen elektron sayısı elektrot reaksiyonuna katılan hidrojen iyonu sayısına eşit bulundu. Eşit elektron ve proton sayısı önerilen indirgenme mekanizması ile de desteklendi. DPV analizleri için olanzapinin doğrusal çalışma aralığı pH=7.0 Britton-Robinson tampon çözeltisinde, 2x10-5M - 1x10-4M konsantrasyon aralığında çizildi. Belirme sınırı (LOD) ve kantitatif tayin sınırı (LOQ) sırasıyla 1.88x10-6M ve 6.29x10-6M olarak hesaplandı. Son olarak geliştirilen voltametrik teknik olanzapin içeren tabletlere ve insan idrarına dışarıdan uygulanarak, geri kazanım çalışmaları yapıldı. Bunların yanı sıra olanzapinin indirgenme özelliği için elektrokimyasal bir indirgenme mekanizması da önerildi.

Kaynakça

  • Ahmed, H. M., Mohamed, M. A., & Salemb, W. M. (2015). New voltammetric analysis of Olanzapine in tablets and human urine samples using a modified carbon paste sensor electrode incorporating gold nanoparticles and glutamine in a micellar medium, Anal. Methods, 7, 581-589. https://doi.org/10.1039/C4AY02450H
  • Azab, S. M., & Amany M. Fekry, A. M. (2019). Role of green chemistry in antipsychotics’ electrochemical investigations using a nontoxic modified sensor in mcilvaine buffer solution, ACS Omega, 4, 25-30. https://doi.org/10.1021/acsomega.8b01972
  • Behzad, L. M., Ghoviland, M. B., Shamsipur, M., Ghoviland, K., Barati, A., & Gholami, A. (2016). Highly sensitive voltammetric sensor based on immobilization of bisphosphoramidate-derivative and quantum dots onto multi-walled carbon nanotubes modified gold electrode for the electrocatalytic determination of Olanzapine, Materials Science and Engineering C, 60, 67-77. https://doi.org/10.1016/j.msec.2015.10.068
  • Berna, M., Ackermann, B.; Ruterbories, K., & Glass, S. (2002). Determination of Olanzapine in human blood by liquid chromatography/tandem mass spectrometry, Journal of Chromatography B., 67, 163-168. DOI: http://doi.org/10.1016/s0378-4347(01)00548-5
  • Biryol,I., & Erk, N. (2013). Voltammetric, spectrophotometric, and high performance liquid chromatographic analysis of Olanzapine, Analytical Letters, 36 (11), 2497–2513. https://doi.org/10.1081/AL-120024338
  • El Shal, M. (2013). Electrochemical studies for the determination of quetiapine fumarate and Olanzapine antipsychotic drugs, Advenced Pharmaceutical Bulletin, 3 (2), 339–344. DOI: 10.5681/apb.2013.055
  • Firdous, S., Aman, T., & Nisa, A. (2005). Determination of Olanzapine by Uv spectrophotometry and non-aqueous titration, J. Chem. Soc. Pak., 27, 163–167. https://www.jcsp.org.pk/ArticleUpload/958-4115-1-RV.pdf
  • Jasinska, A., & Nalewajko, E. (2004). Batch and flow injection methods for the spectrophotometric determination of Olanzapine, Anal. Chim. Acta, 508, 165–170. DOI: https://doi.org/10.1016/j.aca.2003.11.069
  • Karadurmus, L., Kir, D., Kurbanoglu, S., & Ozkan, S. A. (2019). Electrochemical analysis of antipsychotics, Current Pharmaceutıcal Analysıs, 15 (5), 413-428. DOI : 10.2174/1573412914666180710114458
  • Kasper, S.C., Mattiuz, E.L., Swanson, S.P., Chiu, J.A., Johnson, J.T., & Garner, C.O. (1999). Determination of Olanzapine in human breast milk by high-performance liquid chromatography with electrochemical detection, Journal of Chromatography B: Biomedical Sciences and Applications, 726, 203-209. DOI:http://doi.org/10.1016/s0378-4347(99)00017-1
  • Kul, D. 2019. Voltammetric analysis of a typical antipsychotic drugs with solid electrodes, Current Analytıcal Chemıstry, 15 (3), 240-248. DOI : 10.2174/1573411014666180426170022
  • Mashhadizadeh, M. H., & Afshar, E. (2012). Electrochemical studies and selective detection of thioridazine using a carbon paste electrode modified with zn nanoparticles and simultaneous determination of Thioridazine and Olanzapine, Electroanalysis, 24 (11), 2193 – 2202. https://doi.org/10.1002/elan.201200422
  • Merli, D., Dondi, D., Pesavento, M., & Profumo, A. (2012). Electrochemistry of Olanzapine and risperidone at carbon nanotubes modified gold electrode through classical and dft approaches, Journal of Electroanalytical Chemistry, 683, 103–111. DOI: 10.1016/j.jelechem.2012.08.011
  • Olanzapine https://medlineplus.gov/druginfo/meds/a601213.html.
  • Pucci, V., Raggi, M., & Kenndler, E. (1999). Separation of eleven central nervous system drugs by capillary zone electrophoresis, Journal of Chromatography B: Biomedical Sciences and Applications, 728, 263-271. https://doi.org/10.1016/S0378-4347(99)00101-2
  • Raggi, M.A., Casamenti, G., Mandrioli, R., Fanali, S., Ronchi, D.D., & Volterra, V. (2000). Determination of the novel antipsychotic drug Olanzapine in human plasma using HPLC with amperometric detection, Chromatographia, 51, 562-566. DOI: 10.1007/BF02490813
  • Rouhani, M., & Soleymanpour, A. (2019). A new selective carbon paste electrode for potentiometric analysis of olanzapine, Measurement, 140, 472-478. DOI: 10.1016/j.measurement.2019.04.018
  • Shahrokhian, S., Azimzadeha, M., & Hosseinia, P. (2014). Modification of a glassy carbon electrode with a bilayer of multiwalled carbon nanotube/benzenedisulfonate-doped polypyrrole: Application to sensitive voltammetric determination of Olanzapine, RSC Adv., 4 , 4055-4060. https://doi.org/10.1039/C4RA04584J
  • Yılmaz, B., Albayrak, M., & Kadioglu, Y. (2017). Determination of Olanzapine in pharmaceutical preparations by linear sweep voltammetry method, CBU J. Of Sci., 13 (1), 99-104. https://doi.org/10.18466/cbayarfbe.302648

Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals

Yıl 2020, Cilt 6, Sayı 2, 342 - 352, 29.12.2020

Öz

The electrochemical reduction behavior of olanzapine was investigated by DPV (differential pulse voltammetry) and CV (cyclic voltammetry) techniques using a glassy carbon electrode. The measurements were carried out in different buffer solutions in a pH range from 0.50 to 12.05. The behavior of the peak potential and the peak current were examined by changing the pH, and a pH= 7.0 Britton-Robinson buffer solution was selected as the supporting electrolyte. To designate the electron and proton numbers that participated in the reaction, the changing peak potentials of olanzapine with increasing pH were investigated. The number of transferred electrons was found equal to the number of the hydrogen ions taking part in the electrode reaction. Equal electron and proton numbers were also supported with suggested reduction mechanism. For DPV analysis, the linear calibration curve of olanzapine was plotted between concentrations 2x10-5M and 1x10-4M at the pH= 7.0 Britton-Robinson buffer solution. The limit of detection (LOD) and the limit of quantification (LOQ) were found to be 1.88x10-6 M and 6.29x10-6M, respectively. Lastly, the developed technique was applied to spiked urine and pharmaceutical preparations for recovery studies of olanzapine. A reaction mechanism related to the reduction of olanzapine was also proposed with this study.

Kaynakça

  • Ahmed, H. M., Mohamed, M. A., & Salemb, W. M. (2015). New voltammetric analysis of Olanzapine in tablets and human urine samples using a modified carbon paste sensor electrode incorporating gold nanoparticles and glutamine in a micellar medium, Anal. Methods, 7, 581-589. https://doi.org/10.1039/C4AY02450H
  • Azab, S. M., & Amany M. Fekry, A. M. (2019). Role of green chemistry in antipsychotics’ electrochemical investigations using a nontoxic modified sensor in mcilvaine buffer solution, ACS Omega, 4, 25-30. https://doi.org/10.1021/acsomega.8b01972
  • Behzad, L. M., Ghoviland, M. B., Shamsipur, M., Ghoviland, K., Barati, A., & Gholami, A. (2016). Highly sensitive voltammetric sensor based on immobilization of bisphosphoramidate-derivative and quantum dots onto multi-walled carbon nanotubes modified gold electrode for the electrocatalytic determination of Olanzapine, Materials Science and Engineering C, 60, 67-77. https://doi.org/10.1016/j.msec.2015.10.068
  • Berna, M., Ackermann, B.; Ruterbories, K., & Glass, S. (2002). Determination of Olanzapine in human blood by liquid chromatography/tandem mass spectrometry, Journal of Chromatography B., 67, 163-168. DOI: http://doi.org/10.1016/s0378-4347(01)00548-5
  • Biryol,I., & Erk, N. (2013). Voltammetric, spectrophotometric, and high performance liquid chromatographic analysis of Olanzapine, Analytical Letters, 36 (11), 2497–2513. https://doi.org/10.1081/AL-120024338
  • El Shal, M. (2013). Electrochemical studies for the determination of quetiapine fumarate and Olanzapine antipsychotic drugs, Advenced Pharmaceutical Bulletin, 3 (2), 339–344. DOI: 10.5681/apb.2013.055
  • Firdous, S., Aman, T., & Nisa, A. (2005). Determination of Olanzapine by Uv spectrophotometry and non-aqueous titration, J. Chem. Soc. Pak., 27, 163–167. https://www.jcsp.org.pk/ArticleUpload/958-4115-1-RV.pdf
  • Jasinska, A., & Nalewajko, E. (2004). Batch and flow injection methods for the spectrophotometric determination of Olanzapine, Anal. Chim. Acta, 508, 165–170. DOI: https://doi.org/10.1016/j.aca.2003.11.069
  • Karadurmus, L., Kir, D., Kurbanoglu, S., & Ozkan, S. A. (2019). Electrochemical analysis of antipsychotics, Current Pharmaceutıcal Analysıs, 15 (5), 413-428. DOI : 10.2174/1573412914666180710114458
  • Kasper, S.C., Mattiuz, E.L., Swanson, S.P., Chiu, J.A., Johnson, J.T., & Garner, C.O. (1999). Determination of Olanzapine in human breast milk by high-performance liquid chromatography with electrochemical detection, Journal of Chromatography B: Biomedical Sciences and Applications, 726, 203-209. DOI:http://doi.org/10.1016/s0378-4347(99)00017-1
  • Kul, D. 2019. Voltammetric analysis of a typical antipsychotic drugs with solid electrodes, Current Analytıcal Chemıstry, 15 (3), 240-248. DOI : 10.2174/1573411014666180426170022
  • Mashhadizadeh, M. H., & Afshar, E. (2012). Electrochemical studies and selective detection of thioridazine using a carbon paste electrode modified with zn nanoparticles and simultaneous determination of Thioridazine and Olanzapine, Electroanalysis, 24 (11), 2193 – 2202. https://doi.org/10.1002/elan.201200422
  • Merli, D., Dondi, D., Pesavento, M., & Profumo, A. (2012). Electrochemistry of Olanzapine and risperidone at carbon nanotubes modified gold electrode through classical and dft approaches, Journal of Electroanalytical Chemistry, 683, 103–111. DOI: 10.1016/j.jelechem.2012.08.011
  • Olanzapine https://medlineplus.gov/druginfo/meds/a601213.html.
  • Pucci, V., Raggi, M., & Kenndler, E. (1999). Separation of eleven central nervous system drugs by capillary zone electrophoresis, Journal of Chromatography B: Biomedical Sciences and Applications, 728, 263-271. https://doi.org/10.1016/S0378-4347(99)00101-2
  • Raggi, M.A., Casamenti, G., Mandrioli, R., Fanali, S., Ronchi, D.D., & Volterra, V. (2000). Determination of the novel antipsychotic drug Olanzapine in human plasma using HPLC with amperometric detection, Chromatographia, 51, 562-566. DOI: 10.1007/BF02490813
  • Rouhani, M., & Soleymanpour, A. (2019). A new selective carbon paste electrode for potentiometric analysis of olanzapine, Measurement, 140, 472-478. DOI: 10.1016/j.measurement.2019.04.018
  • Shahrokhian, S., Azimzadeha, M., & Hosseinia, P. (2014). Modification of a glassy carbon electrode with a bilayer of multiwalled carbon nanotube/benzenedisulfonate-doped polypyrrole: Application to sensitive voltammetric determination of Olanzapine, RSC Adv., 4 , 4055-4060. https://doi.org/10.1039/C4RA04584J
  • Yılmaz, B., Albayrak, M., & Kadioglu, Y. (2017). Determination of Olanzapine in pharmaceutical preparations by linear sweep voltammetry method, CBU J. Of Sci., 13 (1), 99-104. https://doi.org/10.18466/cbayarfbe.302648

Ayrıntılar

Birincil Dil İngilizce
Konular Temel Bilimler
Bölüm Araştırma Makalesi
Yazarlar

Sultan YAĞMUR> (Sorumlu Yazar)
CANAKKALE ONSEKIZ MART UNIVERSITY
0000-0002-2329-2451
Türkiye

Destekleyen Kurum Çanakkale Onsekiz Mart Üniversitesi Bilimsel Araştırma Projeleri
Proje Numarası FBA-2018-2702
Erken Görünüm Tarihi 10 Haziran 2022
Yayımlanma Tarihi 29 Aralık 2020
Yayınlandığı Sayı Yıl 2020, Cilt 6, Sayı 2

Kaynak Göster

Bibtex @araştırma makalesi { comufbed695610, journal = {Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi}, eissn = {2459-1580}, address = {}, publisher = {Çanakkale Onsekiz Mart Üniversitesi}, year = {2020}, volume = {6}, number = {2}, pages = {342 - 352}, title = {Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals}, key = {cite}, author = {Yağmur, Sultan} }
APA Yağmur, S. (2020). Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals . Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi , 6 (2) , 342-352 . Retrieved from https://dergipark.org.tr/tr/pub/comufbed/issue/57234/695610
MLA Yağmur, S. "Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals" . Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi 6 (2020 ): 342-352 <https://dergipark.org.tr/tr/pub/comufbed/issue/57234/695610>
Chicago Yağmur, S. "Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals". Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi 6 (2020 ): 342-352
RIS TY - JOUR T1 - Olanzapin'in İndirgenme Davranışının İncelenmesi ve İlaçlar ile İnsan İdrarında Diferansiyel puls Tekniği ile Tayini AU - SultanYağmur Y1 - 2020 PY - 2020 N1 - DO - T2 - Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi JF - Journal JO - JOR SP - 342 EP - 352 VL - 6 IS - 2 SN - -2459-1580 M3 - UR - Y2 - 2020 ER -
EndNote %0 Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals %A Sultan Yağmur %T Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals %D 2020 %J Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi %P -2459-1580 %V 6 %N 2 %R %U
ISNAD Yağmur, Sultan . "Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals". Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi 6 / 2 (Aralık 2020): 342-352 .
AMA Yağmur S. Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals. Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2020; 6(2): 342-352.
Vancouver Yağmur S. Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals. Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2020; 6(2): 342-352.
IEEE S. Yağmur , "Reduction Behaviour of Olanzapine and Its Differansiyel Puls Voltammetric Determination in Human Urine and Pharmaceuticals", Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi, c. 6, sayı. 2, ss. 342-352, Ara. 2020

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