Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil

Nuraniye Eruygur; Ümit Muhammet Koçyiğit; Mehmet Ataş; Özge Çevik; Faik Gökalp; Parham Taslimi; İlhami Gülçin

doi:10.17776/csj.911818

EN

Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil

Abstract

The current research aimed to determine and report in vitro antioxidant, antimicrobial, antibiofilm, cytotoxic, anti-cholinesterase, and anti-diabetic properties and the stability of the major component of basic oil of Thymbra spicata var. spicata through different phases as theoretically. Essential oil exhibits potential biological activities because of the multiple components it contains.In the current research, the evaluation of Thymbra spicata essential oil antioxidant properties was conducted utilizing 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS) radical scavenging activity.Antimicrobial activity was assessed from minimum inhibition concentration (MIC) using the technique of microdilution and cytotoxicity activity was evaluated by MTT assay through MCF-7 and PC3 human cancer cell lines.Consequently, Cytotoxic activity was evaluated by means of MTT assay utilized. The essential oil was detected to have 340 µg/mL inhibiting influence on the growth of PC3 prostate cancer cells with IC50 value. Also, the T. spicata plant was observed to significantly repress the enzymes, namely acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glycosidase. IC50 values of enzymes were obtained 0.23 µg/mL for AChE, 1.64 µg/mL for BChE, 7.78 µg/mL for α-glycosidase. It was concluded that this plant may be used for Alzheimer's and diabetes disease.

Keywords

Thymbra spicata, Antioxidant activity, Antimicrobial activity, Cytotoxicity, Enzyme activity

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Research Article

Authors

Nuraniye Eruygur
0000-0002-4674-7009
Türkiye

Ümit Muhammet Koçyiğit
0000-0001-8710-2912
Türkiye

Mehmet Ataş
0000-0002-9425-0080
Türkiye

Özge Çevik
Türkiye

Faik Gökalp ^*
0000-0003-4363-3839
Türkiye

Parham Taslimi
0000-0002-3171-0633
Türkiye

İlhami Gülçin
0000-0001-5993-1668
Türkiye

Publication Date

September 24, 2021

Submission Date

April 8, 2021

Acceptance Date

September 7, 2021

Published in Issue

Year 2021 Volume: 42 Number: 3

DOI

https://doi.org/10.17776/csj.911818

IZ

https://izlik.org/JA63NG25MY

APA

Eruygur, N., Koçyiğit, Ü. M., Ataş, M., Çevik, Ö., Gökalp, F., Taslimi, P., & Gülçin, İ. (2021). Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil. Cumhuriyet Science Journal, 42(3), 565-575. https://doi.org/10.17776/csj.911818

AMA

1.Eruygur N, Koçyiğit ÜM, Ataş M, et al. Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil. CSJ. 2021;42(3):565-575. doi:10.17776/csj.911818

Chicago

Eruygur, Nuraniye, Ümit Muhammet Koçyiğit, Mehmet Ataş, et al. 2021. “Composition Characterization and Biological Activity Study of Thymbra Spicata L. Var. Spicata Essential Oil”. Cumhuriyet Science Journal 42 (3): 565-75. https://doi.org/10.17776/csj.911818.

EndNote

Eruygur N, Koçyiğit ÜM, Ataş M, Çevik Ö, Gökalp F, Taslimi P, Gülçin İ (September 1, 2021) Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil. Cumhuriyet Science Journal 42 3 565–575.

IEEE

[1]N. Eruygur et al., “Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil”, CSJ, vol. 42, no. 3, pp. 565–575, Sept. 2021, doi: 10.17776/csj.911818.

ISNAD

Eruygur, Nuraniye - Koçyiğit, Ümit Muhammet - Ataş, Mehmet - Çevik, Özge - Gökalp, Faik - Taslimi, Parham - Gülçin, İlhami. “Composition Characterization and Biological Activity Study of Thymbra Spicata L. Var. Spicata Essential Oil”. Cumhuriyet Science Journal 42/3 (September 1, 2021): 565-575. https://doi.org/10.17776/csj.911818.

JAMA

1.Eruygur N, Koçyiğit ÜM, Ataş M, Çevik Ö, Gökalp F, Taslimi P, Gülçin İ. Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil. CSJ. 2021;42:565–575.

MLA

Eruygur, Nuraniye, et al. “Composition Characterization and Biological Activity Study of Thymbra Spicata L. Var. Spicata Essential Oil”. Cumhuriyet Science Journal, vol. 42, no. 3, Sept. 2021, pp. 565-7, doi:10.17776/csj.911818.

Vancouver

1.Nuraniye Eruygur, Ümit Muhammet Koçyiğit, Mehmet Ataş, Özge Çevik, Faik Gökalp, Parham Taslimi, İlhami Gülçin. Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil. CSJ. 2021 Sep. 1;42(3):565-7. doi:10.17776/csj.911818