Synthesis and Biological Evaluation of Novel 5,8-Dibromo-2-N-substituted-1,4-Naphthoquinone Derivatives as Potential Antimicrobial Agents

Yıl 2018, Cilt: 39 Sayı: 3, 608 - 614, 30.09.2018

Kıymet Berkil Akar Eda Mercan Barış Eran Bilge Hilal Çadırcı

https://doi.org/10.17776/csj.350308

Öz

The seven 5,8-dibromo-2-N-substituted-1,4-naphthoquinone
derivatives have been synthesized and tested for their in vitro antimicrobial
activities. The results suggest that the synthesized 2-N-substituted-1,4-naphthoquinones
have high antimicrobial activity. The diffusion capacities of the compounds are
also important for the determination of the antimicrobial activities; 2c, 2f and 2g have been
shown to be promising compounds for future studies.

Anahtar Kelimeler

1, 4-Naphthoquinone, nucleophilic substitution, antimicrobial activity, antimicrobial activity

Potansiyel Antimikrobiyal Ajanlar Olarak Yeni 5,8-Dibromo-2-N-Sübstitüe-1,4-Naftokinon Türevlerinin Sentezi ve Biyolojik Değerlendirmesi

Öz

Yedi adet
5,8-dibromo-2-N-sübstitüe-1,4-naftakinon türevi sentezlenmiş ve bu
bileşiklerin in vitro antimikrobiyal aktiviteleri test edilmiştir. Elde edilen
sonuçlar 2-N-sübstite-1,4-naftakinonların yüksek antimikrobiyal etkinliğe sahip
olduklarını göstermektedir. Bileşiklerin difüzyon kapasitesi de antimikrobiyal
aktivitelerin belirlenmesinde önem taşımaktadır; Sonuçlar 2c, 2f ve 2g bileşiklerinin gelecekteki
çalışmalar için umut verici bileşikler olduklarını ortaya koymuştur.

Anahtar Kelimeler

1, 4-Naftakinon, nükleofilik yerdeğiştirme, antimikrobiyal aktivite

Kaynakça

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