Relationship between human leukocyte antigen (HLA) alleles and pediatric autoimmune neuropsychiatric disorders associated with Streptococcal infections (PANDAS)
Abstract
Purpose: The aim of this study is to examine the relationship between Pediatric autoimmune neuropsychiatric disorders associated with Streptococcal infections (PANDAS) and Human Leukocyte Antigen (HLA) alleles.
Materials and Methods: HLA alleles of 41 children patients, whom are diagnosed with rapid onset of obsessive compulsive disorder (OCD), and 88 healthy children are analyzed by using PCR. Results are evaluated by using univariate and multivariate logistic regression analysis.
Results: DRB8, DRB5.2 and DQ5 alleles increase risk of disease while A1, B18 and B35 alleles decrease risk of disease.
Conclusion: Findings of this study will help researchers to examine related genes in PANDAS and the effects of gene products on development of the disease. Presentation of exogenic antigens to T-helper cells by HLA class II loci is determined in different autoimmune diseases. Similarity of these findings with PANDAS etiology and risk increasing alleles found in this study being HLA class II is remarkable.
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