Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?

Year 2019, Volume: 44 Issue: Supplement 1, 547 - 554, 29.12.2019

Burak Elmas , Mehmet Ferdi Kıncı , İrem Eda Gök Afra Alkan , Cihan Toğrul , Esma Sarıkaya

https://doi.org/10.17826/cumj.558401

Cited By: 2

Abstract

Purpose: The aim of this study was to evaluate the role of potential autoimmune mechanisms in the pathogenesis of preeclampsia by investigating the coexistence of celiac disease in patients. 

Material and Methods: Forty women diagnosed with preeclampsia and forty non-complicated pregnant women were enrolled in this prospective, cross-sectional, case-control study. Both groups were compared for any allergic disease symptoms, serological markers of celiac disease, total Ig A and total Ig E levels. Two years later, the mothers were questioned about the presence of allergic diseases in their babies. 

Results: There was no statistically significant difference between the two groups for serological markers of celiac disease. However, total IgE levels of the preeclampsia group were significantly higher than that of the control group. 

Conclusion: In this study, we did not ascertain any coexistence of celiac disease and preeclampsia. Nevertheless, we suggest that the increased IgE levels in the preeclampsia group might be accepted as an indicator of the immune pathogenesis of preeclampsia and a potential marker for coexisting allergic diseases. 

Keywords

Preeclampsia, celiac disease, Ig E

Preeklamptik gebeliklerde yüksek IgE seviyeleri, otoimmün patofizyolojiye işaret ediyor mu?

Abstract

Amaç: Bu çalışmada preeklampsi patogenezindeki potansiyel immun mekanizmaların, hastalarda çölyak hastalığı bulunup bulunmamasıyla değerlendirmesi amaçlanmıştır. 

Gereç ve Yöntem: Kesitsel, vaka kontrolü ve prospektif çalışmaya preeklampsi tanısı konmuş 40 gebe ve 40 komplikasyonu olmayan gebe alındı. Her iki grup alerjik hastalık semptomları, çölyak hastalığına ait serolojik belirteçler, total Ig A ve total Ig E düzeyleri yönünden karşılaştırıldı. İki yıl sonra anneler bebeklerinde alerjik hastalık varlığı açısından sorgulandı.

Bulgular: Çölyak hastalığına özgü serolojik belirteçleri açısından karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı bir fark bulunmadı. Ancak, çalışma grubundaki toplam IgE düzeyleri kontrol grubununkilere göre anlamlı olarak daha yüksek olarak gözlendi.

Sonuç: Bu çalışmada, çölyak hastalığı ve preeklampsi birlikteliğine ait net olarak herhangi bir sonuç bulunmadı. Ancak, preeklampsi grubunda artmış IgE düzeylerinin, bu hastalığın immün patogenezine ait bir işaret olabileceğini ve eşlik eden alerjik hastalıklara ait potansiyel bir belirteç olarak kabul edilmesini öneriyoruz. 

Keywords

Preeklampsi, Çölyak hastalığı, Ig E

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